| Southern Wesleyan University | Central | B42Z Education | $29.5M | 3 |
| COKER UNIVERSITY | Hartsville | B420 Education | $29.4M | 7 |
| ROLLING GREEN VILLAGE | Greenville | — | $29.1M | 6 |
| EDGEFIELD COUNTY PUBLIC FACILITIES CORPORATION | Edgefield | P20 Human Services | $28.5M | 0 |
| SOUTH CAROLINA MEDICAL ASSOCIATION MEMBERS' INSURANCE TRUST | Columbia | Y43 Mutual & Membership Benefit | $28.3M | 4 |
| SOUTH CAROLINA PROPERTY AND CASUALTY INSURANCE GUARANTY ASSOC | Columbia | — | $28.1M | 0 |
| WESLEY COMMONS | Greenwood | P750 Human Services | $28.1M | 7 |
| Affinity Health Center | Rock Hill | G81 Diseases, Disorders & Medical Disciplines | $27.7M | 7 |
| LOW COUNTRY HEALTH CARE SYSTEM INC | Fairfax | E32 Health Care | $27.7M | 8 |
| Heathwood Hall Episcopal School | Columbia | B200 Education | $27.1M | 7 |
| Charleston School of Law | Charleston | B28 Education | $27.1M | 1 |
| SOUTH CAROLINA YOUTH ADVOCATE PROGRAM INC | Columbia | P320 Human Services | $26.9M | 8 |
| Upstate Senior Living Inc | Greenville | P75 Human Services | $26.5M | 8 |
| MIRACLE HILL MINISTRIES INC | Greenville | P200 Human Services | $26.3M | 4 |
| JAMES ISLAND CHARTER HIGH SCHOOL | Charleston | B29 Education | $26.1M | 6 |
| Insurance Institute for Business & Home Safety | Richburg | M40 Public Safety, Disaster Preparedness & Relief | $26M | 10 |
| SOUTH CAROLINA VIRTUAL CHARTER SCHOOL | West Columbia | B99 Education | $26M | 14 |
| Allen University | Columbia | B43Z Education | $25.9M | 6 |
| THE CYPRESS CLUB INC | Hilton Head Island | — | $25.9M | 5 |
| HAMMOND SCHOOL | Columbia | B24Z Education | $25.7M | 7 |
| LEGACY EARLY COLLEGE | Greenville | B29 Education | $25.5M | 6 |
| Kiawah Island Community Association Inc | Kiawah Island | L50 Housing & Shelter | $24.7M | 8 |
| ASHLEY HALL FOUNDATION | Charleston | B200 Education | $24.3M | 8 |
| Leroy Springs & Company Inc | Fort Mill | N300 Recreation & Sports | $24.1M | 7 |
| SOUTHSIDE CHRISTIAN SCHOOL OF THE UPSTATE | Simpsonville | B25 Education | $24.1M | 5 |
| FETTER HEALTH CARE NETWORK INC | Charleston | — | $23.9M | 10 |
| UPPER PALMETTO YMCA INC | Rock Hill | P27Z Human Services | $23.2M | 5 |
| Self Regional Healthcare Partners | Greenwood | E20 Health Care | $22.9M | 2 |
| KERSHAWHEALTH | Camden | E220 Health Care | $22.2M | 11 |
| COMMUNITY SERVICES ASSOCIATES INC | Hilton Head Island | L50 Housing & Shelter | $22.1M | 7 |
| BERKELEY CHARTER EDUCATION ASSOCIATION I | Goose Creek | B29 Education | $22.1M | 0 |
| SCAGO EDUCATIONAL FACILITIES CORP FOR PICKENS COUNTY SCHOOL DISTRICT | Easley | B112 Education | $22M | 2 |
| Greenville Country Club | Greenville | — | $21.9M | 7 |
| HEALTH CARE PARTNERS OF SOUTH CAROLINA INC | Conway | E320 Health Care | $21.8M | 9 |
| TRI-DEVELOPMENT CENTER OF AIKEN COUNTY INC | Aiken | — | $21.3M | 3 |
| RURAL HEALTH SERVICES INC | Aiken | — | $21.3M | 13 |
| COLLEGE OF CHARLESTON FOUNDATION | Charleston | B114 Education | $21.2M | 5 |
| CHILDREN'S TRUST OF SOUTH CAROLINA | Columbia | P34J Human Services | $20.8M | 4 |
| AMERICAN LEADERSHIP ACADEMY SOUTH CAROLINA | Lexington | B29 Education | $20.5M | 1 |
| South Carolina Aquarium | Charleston | D500 Animal-Related | $20.3M | 11 |
| ORANGE GROVE CHARTER SCHOOL | Charleston | B29 Education | $20.1M | 1 |
| CARETEAM PLUS INC | Conway | E80 Health Care | $20M | 6 |
| NATIONAL ASSOCIATION OF COMPETITIVE SOCCER CLUBS D/B/A US CLUB SOCCER | Mt Pleasant | O50 Youth Development | $20M | 3 |
| YORK COUNTY BOARD OF DISABILITIES AND SPECIAL NEEDS | York | — | $19.9M | 2 |
| MORRIS COLLEGE | Sumter | B42Z Education | $19.8M | 5 |
| SPC CREDIT UNION | Hartsville | — | $19.8M | 5 |
| United States Endowment for Forestry | Greenville | C34 Environment | $19.5M | 10 |
| YORK PREPARATORY ACADEMY INC | Rock Hill | B29 Education | $19.5M | 5 |
| FAMILY HEALTH CENTERS INC | Orangeburg | — | $19.4M | 10 |
| MOORE FARMS BOTANICAL GARDEN FOUNDATION | Lake City | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $19.4M | 1 |
