| THE SOSLAND FOUNDATION | Kansas City | — | $4.2M | 1 |
| CSD CREDIT UNION | Kansas City | — | $4.2M | 1 |
| SAUL MIROWITZ JEWISH | St Louis | B20Z Education | $4.2M | 2 |
| LEAST OF THESE INC | Ozark | P60 Human Services | $4.2M | 1 |
| Kansas City Hospice Foundation | Kansas City | E24Z Health Care | $4.2M | 3 |
| SPRINGFIELD CONVENTION AND VISITORS | Springfield | — | $4.2M | 1 |
| CAPE GIRARDEAU COMMUNITY SHELTERED | Cape Girardeau | J33Z Employment | $4.2M | 1 |
| UKRAINE PARTNERSHIP FOUNDATION | Chesterfield | B12 Education | $4.2M | 0 |
| GINGERBREAD HOUSE INC | Rolla | P73Z Human Services | $4.2M | 1 |
| SPRINGFIELD VICTORY MISSION INC | Springfield | P600 Human Services | $4.2M | 1 |
| FIRST CALL ALCOHOLDRUG PREVENTION | Kansas City | — | $4.1M | 1 |
| COMMUNITY PARTNERSHIP OF SOUTHEAST | Cape Girardeau | S50P Community Improvement & Capacity Building | $4.1M | 1 |
| GREEN HILLS COMMUNITY ACTION AGENCY | Trenton | P20Z Human Services | $4.1M | 1 |
| Scripted Healthcare System | Kansas City | E01 Health Care | $4.1M | 3 |
| OPTIMIST INTERNATIONAL | Saint Louis | — | $4.1M | 5 |
| RIO VISTA FOUNDATION | St Louis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.1M | 0 |
| PINE VIEW MANOR INC | Stanberry | E91Z Health Care | $4.1M | 2 |
| MINER ALUMNI ASSOCIATION | Rolla | B84Z Education | $4.1M | 0 |
| CENTRAL WORKFORCE DEVELOPMENT | Rolla | J99 Employment | $4.1M | 2 |
| INTERNATIONAL BROTHERHOOD OF ELECTRICAL | Fenton | — | $4.1M | 5 |
| STS JOACHIM AND ANN CARE SERVICE | St Charles | — | $4.1M | 1 |
| The German St Vincent Orphan Association | St Louis | — | $4.1M | 1 |
| Jack F and Glenna Y Wylie Charitable Fdn Tr | Kansas City | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.1M | 1 |
| THRIVE ST LOUIS INC | St Louis | E400 Health Care | $4.1M | 1 |
| Bayer Fund | St Louis | — | $4M | 0 |
| NORTHLAND EARLY EDUCATION CENTER | Kansas City | — | $4M | 1 |
| ST FRANCOIS COUNTY BOARD FOR THE | Farmington | G20 Diseases, Disorders & Medical Disciplines | $4M | 2 |
| Welcome House Inc | Kansas City | F22Z Mental Health & Crisis Intervention | $4M | 1 |
| Love Columbia Corp | Columbia | P20 Human Services | $4M | 0 |
| AVENUE OF LIFE INC | Kansas City | P20 Human Services | $4M | 1 |
| FAIR ACRES FAMILY YMCA INC | Carthage | P27Z Human Services | $4M | 1 |
| CROSSROADS REAL ESTATE COMPANY | Kansas City | — | $4M | 1 |
| MISSOURI RURAL WATER ASSOCIATION | Ashland | — | $4M | 2 |
| CIRCLE OF CONCERN | Valley Park | P600 Human Services | $4M | 1 |
| Delta Center Personal Attendant Services | Saint Peters | P80 Human Services | $4M | 1 |
| EDUCATIONAL COMMUNITY CREDIT UNION | Springfield | — | $4M | 5 |
| TECHNOLOGY ENTREPRENEUR CENTER INC | St Louis | S43 Community Improvement & Capacity Building | $4M | 1 |
| JOPLIN METRO CREDIT UNION | Joplin | — | $4M | 2 |
| KANSAS CITY AUTISM TRAINING | Kansas City | B28 Education | $4M | 1 |
| LABORERS INTERNATIONAL UNION OF | Kansas City | — | $4M | 12 |
| WORLD CHESS MUSEUM INC | St Louis | A11 Arts, Culture & Humanities | $4M | 1 |
| HEALING HOUSE INC | Kansas City | P99 Human Services | $4M | 2 |
| UNIVERSITY OF MISSOURI LAW SCHOOL | Columbia | — | $3.9M | 1 |
| BELLEFONTAINE CEMETERY ASSOCIATION | St Louis | — | $3.9M | 4 |
| ERIC P & EVELYN E NEWMAN CHARITABLE | Saint Louis | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $3.9M | 0 |
| GUARDIAN ANGEL SETTLEMENT ASSOCIATION | St Louis | P33Z Human Services | $3.9M | 1 |
| ST LOUIS GLASS & ALLIED INDUSTRIES | Saint Louis | — | $3.9M | 1 |
| MUSTARD SEED NETWORK | Oronogo | X20 Religion-Related | $3.9M | 5 |
| Alexian Brothers Bonaventure House | St Louis | — | $3.9M | 7 |
| THE BLACK-CHESLIK FAMILY FOUNDATION | Kansas City | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.9M | 0 |
