| PI BETA PHI FOUNDATION | Town Country | — | $4.8M | 1 |
| LAFAYETTE WORK CENTER INC | Manchester | J33Z Employment | $4.8M | 4 |
| KINGDOM HOUSE D/B/A LIFEWISE STL | St Louis | O50 Youth Development | $4.8M | 1 |
| ALABAMA GAS CORPORATION RETIRED HOURLY EMPLOYEE BENEFIT PLANS TRUST | St Louis | — | $4.8M | 0 |
| STONECROFT MINISTRIES INC | Kansas City | X200 Religion-Related | $4.8M | 3 |
| ON MY OWN INC | Nevada | P99 Human Services | $4.8M | 0 |
| TW L D MCEACHEARN | Saint Louis | T900 Philanthropy, Voluntarism & Grantmaking Foundations | $4.8M | 1 |
| IRONWORKERS LOCAL UNION 396 | Saint Louis | — | $4.8M | 17 |
| THE DEBRUCE FOUNDATION | Kansas City | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.8M | 1 |
| MULTI-STATES CREDIT UNION | Springfield | — | $4.8M | 1 |
| Care to Learn | Springfield | P40 Human Services | $4.8M | 1 |
| GATEWAY ARCH PARK FOUNDATION | St Louis | N32 Recreation & Sports | $4.8M | 3 |
| THE ST ANTHONY HOSPITAL FOUNDATION INC | St Louis | E112 Health Care | $4.7M | 2 |
| PEACE HAVEN ASSOCIATION INC | St Louis | X20Z Religion-Related | $4.7M | 1 |
| MUSTARD SEED NETWORK | Oronogo | X20 Religion-Related | $4.7M | 4 |
| K-LIFE MINISTRIES | Branson | — | $4.7M | 1 |
| TORAH CENTER-MIDWEST INC | Saint Louis | — | $4.7M | 6 |
| SHERWOOD FOREST CAMP INC | St Louis | O43Z Youth Development | $4.7M | 1 |
| JP Humphreys Foundation | Joplin | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.7M | 0 |
| HEALTH CARE FAMILY CREDIT UNION | St Louis | — | $4.7M | 3 |
| Annie Malone Children and Family Service | Saint Louis | P300 Human Services | $4.7M | 1 |
| BLAQUE | Kansas City | — | $4.7M | 1 |
| SHEFFIELD PLACE | Kansas City | L40Z Housing & Shelter | $4.7M | 1 |
| BERRY FOUNDATION | Kansas City | B60 Education | $4.7M | 8 |
| NOURISHKC | Kansas City | X20 Religion-Related | $4.7M | 0 |
| Optometry Cares - The AOA Foundation | St Louis | P20 Human Services | $4.7M | 3 |
| MID-AMERICA REGIONAL COUNCIL COMMUNITY SERVICES CORPORATION | Kansas City | S12 Community Improvement & Capacity Building | $4.6M | 7 |
| NEIGHBORHOOD SOLIDARITY FUND | St Louis | S20 Community Improvement & Capacity Building | $4.6M | 1 |
| FRANKLIN COUNTY CHILDREN & FAMILIES COMMUNITY RESOURCE BOARD ASSOCIATION | Union | P20 Human Services | $4.6M | 0 |
| SAINT FRANCIS FOUNDATION | Cape Girardeau | — | $4.6M | 8 |
| LAKE OF THE OZARK DEVELOPMENTAL CEN | Camdenton | P82Z Human Services | $4.6M | 1 |
| GREAT RIVERS GREENWAY FOUNDATION | St Louis | S20 Community Improvement & Capacity Building | $4.6M | 1 |
| MERCY RESEARCH | Springfield | — | $4.6M | 20 |
| CONSTRUCTION LABORERS AND CONTRACTORS TRAINING FUND OF EASTERN MISSOURI | High Hill | — | $4.6M | 4 |
| POSTAL & COMMUNITY CREDIT UNION | St Joseph | — | $4.6M | 5 |
| IBEW LOCAL #1 APPRENTICESHIP AND TRAINING FUND | St Louis | — | $4.6M | 0 |
| UNITED CEREBRAL PALSY OF NORTHWEST MISSOURI | Saint Joseph | G23Z Diseases, Disorders & Medical Disciplines | $4.6M | 1 |
| International Union UAW LOCAL 2250 | Wentzville | — | $4.6M | 11 |
| PALESTINE GARDENS NORTH INC | Lees Summit | L22Z Housing & Shelter | $4.6M | 0 |
| INTERNATIONAL BROTHERHOOD OF ELECTRICAL WORKERS LOCAL NO 2 | Fenton | — | $4.6M | 6 |
| POWERHOUSE COMMUNITY DEVELOPMENT CORPORATON | Marshall | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $4.6M | 1 |
| ST LOUIS YOUTH SOCCER ASSOCIATION | St Louis | — | $4.6M | 1 |
| EMPAC INDUSTRIAL RESOURCES INC | Sullivan | — | $4.5M | 0 |
| THE CENTER FOR HEAD INJURY SERVICES | St Louis | — | $4.5M | 6 |
| Robert W Plaster Foundation Inc | Lebanon | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.5M | 1 |
| INDEPENDENT LIVING CENTER OF S E MO SOUTHEAST MISSOURI | Poplar Bluff | P80 Human Services | $4.5M | 1 |
| Borgess Health Alliance Inc | St Louis | E21 Health Care | $4.5M | 14 |
| HEAT UP ST LOUIS INC | St Louis | P20 Human Services | $4.5M | 1 |
| GREATER KANSAS CITY SPORTS COMMISSION | Kansas City | — | $4.5M | 6 |
| GENESIS SCHOOL INC | Kansas City | B25Z Education | $4.5M | 2 |
