| ARKANSAS FOODBANK | Little Rock | K190 Food, Agriculture & Nutrition | $74.8M | 5 |
| SARH HOLDINGS INC | El Dorado | E20 Health Care | $73.3M | 4 |
| Baptist Health Services | Little Rock | E11 Health Care | $72.3M | 11 |
| GOODWILL INDUSTRIES OF ARKANSAS INC | Little Rock | — | $70.1M | 8 |
| Town Branch Foundation | Bentonville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $66.6M | 2 |
| Walton Family Charitable Support Foundation Inc | Bentonville | T900 Philanthropy, Voluntarism & Grantmaking Foundations | $65.3M | 5 |
| EASTERSEALS ARKANSAS | Little Rock | E50Z Health Care | $64.9M | 8 |
| CENTRAL ARKANSAS DEVELOPMENT COUNCIL | Benton | S30Z Community Improvement & Capacity Building | $64.2M | 3 |
| Arvest Bank Group Welfare Benefits Plan TRUST | Lowell | — | $64.1M | 0 |
| MOUNTAIRE EMPLOYEES MEDICAL BENEFIT TRUST | Little Rock | — | $57.2M | 0 |
| WOODRUFF ELECTRIC COOPERATIVE CORP | Forrest City | — | $57.2M | 17 |
| ARKANSAS COLLEGES OF HEALTH EDUCATION | Fort Smith | B43 Education | $57M | 10 |
| MAINLINE HEALTH SYSTEMS INC | Dermott | E21Z Health Care | $53.8M | 12 |
| ARKANSAS CHILDREN'S RESEARCH INSTITUTE | Little Rock | — | $53.8M | 13 |
| C & L ELECTRIC COOPERATIVE CORPORATION | Star City | — | $52.3M | 15 |
| WALTON ARTS CENTER COUNCIL INC | Fayetteville | A260 Arts, Culture & Humanities | $52.3M | 11 |
| FRIENDSHIP COMMUNITY CARE INC | Russellville | J330 Employment | $51M | 6 |
| ST FRANCIS HOUSE NWA INC | Springdale | E32Z Health Care | $50.5M | 6 |
| Alumbra Innovations Foundation | Bentonville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $48.8M | 0 |
| BILL HILLARY & CHELSEA CLINTON FOUNDATION | Little Rock | E70 Health Care | $48.6M | 15 |
| ARKANSAS HOSPICE INC | North Little Rock | P740 Human Services | $46.9M | 11 |
| BIRCH TREE COMMUNITIES INC | Benton | F330 Mental Health & Crisis Intervention | $46.8M | 9 |
| THE JESUS FUND (SECTION 501(C)(3) EXEMPT PRIVATE FOUNDATION) | Little Rock | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $46.5M | 1 |
| LITTLE SCHOLARS OF ARKANSAS FOUNDATION | Little Rock | B19 Education | $45.9M | 3 |
| AWAKENING FOUNDATION | Conway | X12 Religion-Related | $45.5M | 1 |
| WHITE COUNTY PHYSICIANS GROUP | Searcy | E11 Health Care | $45.2M | 8 |
| Pathfinder Inc | Jacksonville | J330 Employment | $42.9M | 3 |
| UNIVERSITY OF THE OZARKS | Clarksville | B430 Education | $42.8M | 5 |
| Crawford-Sebastian Community Development Council Inc | Fort Smith | S200 Community Improvement & Capacity Building | $42.6M | 1 |
| JOHNSON REGIONAL MEDICAL CENTER | Clarksville | E220 Health Care | $41.9M | 7 |
| ARKANSAS FOUNDATION FOR MEDICAL CARE INC | Fort Smith | E03 Health Care | $41.3M | 29 |
| OZARK HEALTH INC VAN BUREN CO MEM HOSP & NURSING HOME | Clinton | E22 Health Care | $40.7M | 5 |
| ARKANSAS STATE UNIVERSITY SYSTEM FOUNDATION INC | State University | B110 Education | $39.4M | 3 |
| Total Life Healthcare Inc | Jonesboro | — | $38.9M | 7 |
| OUACHITA COUNTY MEDICAL CENTER | Camden | E22Z Health Care | $38.7M | 6 |
| CROSSETT HEALTH FOUNDATION DBA ASHLEY COUNTY MEDICAL CENTER | Crossett | E22I Health Care | $38.6M | 6 |
| BOST INC | Fort Smith | P82Z Human Services | $38.4M | 3 |
| EAST ARKANSAS FAMILY HEALTH CENTER INC | West Memphis | — | $38.4M | 8 |
| Boston Mountain Rural Health Center Inc | Marshall | E320 Health Care | $37.6M | 12 |
| HEALTHY CONNECTIONS INC | Mena | E70 Health Care | $36.7M | 6 |
| ST BERNARDS HEALTHCARE INC | Jonesboro | — | $35.8M | 8 |
| ARKANSAS CHILDREN'S INC | Little Rock | E19 Health Care | $35.2M | 20 |
| Clay County Electric Coop Corp | Corning | — | $35.2M | 15 |
| ARKANSAS VIRTUAL ACADEMY | Little Rock | B29 Education | $34.8M | 0 |
| E-STEM HIGH PUBLIC CHARTER SCHOOLS INC | Little Rock | B25 Education | $34.6M | 3 |
| SOUTH CENTRAL ARKANSAS ELECTRIC COOPERATIVE INC | Arkadelphia | — | $34.4M | 15 |
| LYON COLLEGE | Batesville | B420 Education | $34.3M | 7 |
| Bella Vista Village Property Owners Assoc | Bella Vista | — | $34.2M | 9 |
| Circle of Life | Springdale | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $34.1M | 5 |
| RAZORBACK FOUNDATION INC | Fayetteville | B110 Education | $33.3M | 8 |
