| PATHWAYS BEHAVIORAL SERVICES INC | Waterloo | F21Z Mental Health & Crisis Intervention | $8.2M | 5 |
| SHELTER HOUSE COMMUNITY SHELTER AND TRANSITION SERVICES | Iowa City | — | $8.2M | 2 |
| Glen Haven Home Inc | Glenwood | E910 Health Care | $8.2M | 2 |
| The Principal Financial Group Foundation Inc | Des Moines | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $8.2M | 1 |
| THE CEDAR MEMORIAL PARK CEM ASSN INC MRCHDSE & SRVC TR #2 US BANK NA TRUSTEE | Waterloo | — | $8.1M | 1 |
| SEHGAL FOUNDATION | Des Moines | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $8.1M | 1 |
| GRHS HOLDINGS INC | West Burlington | — | $8M | 5 |
| OPPORTUNITIES UNLIMITED | Sioux City | Z99Z Unknown | $8M | 1 |
| IOWA HEALTHCARE COLLABORATIVE DBA COMPASS HEALTHCARE COLLABORATIVE | Johnston | E03 Health Care | $8M | 14 |
| NORTH IOWA AREA COMMUNITY COLLEGE FOUNDATION C/O MINDY EASTMAN | Mason City | B11 Education | $8M | 0 |
| IOWA PRIMARY CARE ASSOCIATION INC | Des Moines | — | $8M | 8 |
| ANAWIM HOUSING INC | Des Moines | — | $7.9M | 2 |
| SKYLINE CENTER INC | Clinton | J33Z Employment | $7.9M | 0 |
| AASE HAUGEN HOMES INC | Decorah | E91Z Health Care | $7.9M | 2 |
| HYPERION FIELD CLUB | Johnston | — | $7.8M | 5 |
| ALGONA COMMUNITY SCHOOL FOUNDATION | Algona | — | $7.8M | 0 |
| CARROLL COUNTY COUNCIL FOR THE PREVENTION OF CHILD ABUSE | Carroll | I72Z Crime & Legal-Related | $7.7M | 2 |
| BIOCONNECT IOWA | Des Moines | S43 Community Improvement & Capacity Building | $7.7M | 2 |
| MID-AMERICA AGRI-INDUSTRIES VEBA | Sioux City | — | $7.6M | 0 |
| THE CRITTENTON CENTER | Sioux City | P300 Human Services | $7.6M | 1 |
| BRAVO GREATER DES MOINES INC | Des Moines | A122 Arts, Culture & Humanities | $7.6M | 1 |
| ONEOTA RIVERVIEW CARE FACILITY | Decorah | F33Z Mental Health & Crisis Intervention | $7.6M | 1 |
| GIRL SCOUTS OF GREATER IOWA | Urbandale | — | $7.5M | 4 |
| DES MOINES AREA RELIGIOUS COUNCIL | Des Moines | P60 Human Services | $7.5M | 1 |
| SIOUX CENTER CHRISTIAN SCHOOL | Sioux Center | B24Z Education | $7.5M | 0 |
| SIOUXLAND HUMAN INVESTMENT PARTNERSHIP | Sioux City | P20 Human Services | $7.4M | 2 |
| CEDAR RAPIDS SHEET METAL WORKERS LOCAL 263 HEALTH & WELFARE FUND | Cedar Rapids | — | $7.4M | 0 |
| IOWA HIGH SCHOOL ATHLETIC ASSOCIATION | Boone | B114 Education | $7.4M | 5 |
| IOWA ODD FELLOWS AND ORPHANS HOME CORP | Mason City | P70Z Human Services | $7.4M | 3 |
| THE CEDAR RAPIDS COUNTRY CLUB | Cedar Rapids | — | $7.4M | 6 |
| Emmaus Bible College | Dubuque | — | $7.3M | 6 |
| Dubuque County Historical Society | Dubuque | A82Z Arts, Culture & Humanities | $7.3M | 2 |
| CAMP COURAGEOUS OF IOWA | Monticello | P820 Human Services | $7.2M | 1 |
| MANY HANDS FOR HAITI | Pella | P60 Human Services | $7.2M | 0 |
| REGIONAL DEVELOPMENT AUTHORITY | Davenport | — | $7.2M | 1 |
| International Messengers | Clear Lake | X21Z Religion-Related | $7.2M | 5 |
| COMMUNITY HEALTH FREE CLINIC | Cedar Rapids | E30 Health Care | $7.2M | 1 |
| ISU VETERINARY SERVICES CORPORATION | Des Moines | B11 Education | $7.2M | 11 |
| WESTHAVEN COMMUNITY MINISTRY OF THE EVANGELICAL FREE CHURCH | Boone | E910 Health Care | $7.1M | 3 |
| CROW VALLEY GOLF CLUB | Davenport | — | $7.1M | 4 |
| IOWA CITY HOSPICE INC | Iowa City | P74Z Human Services | $7.1M | 3 |
| RSM US FOUNDATION | Davenport | B82 Education | $7M | 0 |
| IOWA JEWISH SENIOR LIFE CENTER | Des Moines | E91 Health Care | $7M | 1 |
| PROTEUS INC | Des Moines | J200 Employment | $7M | 2 |
| OSCEOLA COUNTY RURAL WATER SYSTEM | May City | — | $7M | 10 |
| SCIENCE CENTER OF IOWA | Des Moines | A570 Arts, Culture & Humanities | $7M | 3 |
| STOEL RIVES VEBA TRUST | Des Moines | Y43 Mutual & Membership Benefit | $6.9M | 1 |
| LAKE PANORAMA ASSOCIATION | Panora | — | $6.9M | 11 |
| GREATER SIOUX COMMUNITY HEALTH CENTER INC | Sioux Center | E320 Health Care | $6.9M | 4 |
| FRIENDSHIP ARK INC | Ames | L20 Housing & Shelter | $6.9M | 1 |
