| PLYMOUTH LIFE INC | Le Mars | P820 Human Services | $12.2M | 3 |
| MANATT'S INC GROUP HEALTH PLAN TRUST | Brooklyn | — | $12.2M | 0 |
| FAMILY RESOURCES INC | Davenport | — | $12.1M | 3 |
| Quad City Helicopter Emergency Med | Bettendorf | M23 Public Safety, Disaster Preparedness & Relief | $12.1M | 5 |
| FOUNDATION 2 INC | Cedar Rapids | — | $12M | 4 |
| North Iowa Community Action Organization | Mason City | — | $11.8M | 2 |
| HUBBELL-WATERMAN FNDN | Davenport | — | $11.8M | 0 |
| MERCY FOUNDATION OF DES MOINES IOWA | Des Moines | E120 Health Care | $11.7M | 6 |
| MISSOURI VALLEY LINE CONSTRUCTORS JOINT | Indianola | J21 Employment | $11.7M | 6 |
| Neighborhood Finance Corporation | Des Moines | L22Z Housing & Shelter | $11.6M | 3 |
| OPPORTUNITY LIVING | Lake City | P82Z Human Services | $11.5M | 3 |
| KEOKUK AREA COMMUNITY FOUNDATION | Keokuk | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $11.4M | 0 |
| Cottingham & Butler Insurance Services Inc | Dubuque | — | $11.4M | 0 |
| MERCY HOSPITALCEDAR RAPIDSIA ENDOWMENT | Cedar Rapids | E110 Health Care | $11.3M | 5 |
| THE HAROLD W SIEBENS CHARITABLE | Cedar Rapids | — | $11.3M | 0 |
| ST FRANCIS MANOR | Grinnell | — | $11.2M | 7 |
| CHILDSERVE COMMUNITY OPTIONS | Johnston | S20Z Community Improvement & Capacity Building | $11.1M | 3 |
| IOWA ASSOCIATION FOR THE EDUCATION OF | West Des Moines | B99Z Education | $11.1M | 1 |
| HOSPICE OF DUBUQUE | Dubuque | — | $11M | 7 |
| REACH FOR YOUR POTENTIAL INC | Iowa City | L21Z Housing & Shelter | $10.9M | 1 |
| INVEST DSM | Des Moines | L25 Housing & Shelter | $10.9M | 3 |
| AFFINITY CREDIT UNION | Des Moines | — | $10.8M | 4 |
| WALLACE RESEARCH FOUNDATION | Cedar Rapids | T20J Philanthropy, Voluntarism & Grantmaking Foundations | $10.7M | 0 |
| BRAHMANANDA SARASWATI FOUNDATION | Fairfield | X12 Religion-Related | $10.6M | 1 |
| IOWA CONFLUENCE WATER TRAILS | Des Moines | C32 Environment | $10.4M | 0 |
| BETHANY HOME | Dubuque | E910 Health Care | $10.4M | 1 |
| ANIMAL RESCUE LEAGUE OF IOWA INC | Des Moines | D200 Animal-Related | $10.4M | 2 |
| THE UNITED PRESBYTERIAN HOME | Washington | P750 Human Services | $10.3M | 4 |
| IOWA PORK PRODUCERS ASSOCIATION | Clive | — | $10.3M | 22 |
| GRUNDY COUNTY RURAL ELECTRIC COOPERATIVE | Grundy Center | W80Z Public & Societal Benefit | $10.3M | 8 |
| 1ST GATEWAY CREDIT UNION | Camanche | — | $10.3M | 3 |
| GREATER DES MOINES PARTNERSHIP | Des Moines | S41 Community Improvement & Capacity Building | $10.2M | 11 |
| SIOUXLAND MENTAL HEALTH SERVICES INC | Sioux City | F32Z Mental Health & Crisis Intervention | $10.2M | 6 |
| WESLEYLIFE FOUNDATION | Johnston | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $10.1M | 3 |
| The Catholic Foundation for the | Cedar Rapids | X112 Religion-Related | $10.1M | 1 |
| Faith Baptist Bible College | Ankeny | B42Z Education | $10.1M | 7 |
| HOLY SPIRIT RETIREMENT HOME INC | Sioux City | — | $10M | 2 |
| IOWA PUBLIC RADIO INC | Des Moines | A24 Arts, Culture & Humanities | $10M | 3 |
| OSCEOLA ELECTRIC COOPERATIVE INC | Sibley | — | $10M | 12 |
| GRAND VIEW CHRISTIAN SCHOOL | Des Moines | B99 Education | $9.9M | 2 |
| VISION ATLANTIC INC | Atlantic | L20 Housing & Shelter | $9.9M | 0 |
| FINANCIAL PLUS CREDIT UNION | West Des Moines | — | $9.9M | 0 |
| IOWA MENNONITE BENEVOLENT | Kalona | P74I Human Services | $9.8M | 1 |
| Area Residential Care Inc | Dubuque | P75 Human Services | $9.8M | 2 |
| NORTHWEST IOWA MENTAL HEALTH CENTER | Spencer | F32Z Mental Health & Crisis Intervention | $9.8M | 5 |
| CHRISTIAN HOME ASSN - CHILDREN'S SQUARE | Council Bluffs | P700 Human Services | $9.7M | 4 |
| PELLA COMMUNITY FOUNDATION | Pella | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $9.7M | 0 |
| CENTRAL IOWA RESIDENTIAL SERVICES INC | Marshalltown | P73Z Human Services | $9.7M | 1 |
| NORTHEAST IOWA AREA AGENCY | Waterloo | P81Z Human Services | $9.6M | 2 |
| EVENTIDE LUTHERAN HOME FOR THE AGED | Denison | E91Z Health Care | $9.6M | 1 |
