| PROVIDENCE MEDICAL CENTER | Wayne | — | $31.6M | 6 |
| THE LOZIER FOUNDATION | Omaha | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $31.3M | 1 |
| THE MIDWEST ELECTRIC COOPERATIVE CORPORATION | Grant | — | $31.1M | 16 |
| MEMORIAL COMMUNITY HEALTH INC | Aurora | E22 Health Care | $30.5M | 8 |
| Merrick Medical Center | Central City | E20 Health Care | $30.2M | 10 |
| Father Flanagan's Fund For Needy Children | Boys Town | P110 Human Services | $30M | 7 |
| OPAS FOUNDATION | Omaha | A11 Arts, Culture & Humanities | $29.5M | 3 |
| UNITED WAY OF THE MIDLANDS | Omaha | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $28.9M | 12 |
| NEBRASKA HEALTH INFORMATION INITIATIVE INC | La Vista | W050 Public & Societal Benefit | $28.8M | 2 |
| OPEN DOOR MISSION D/B/A OPEN DOOR MISSION & LYDIA HOUSE | Omaha | P600 Human Services | $28.6M | 2 |
| NEBRASKA METHODIST COLLEGE OF NURSING AND ALLIED HEALTH | Omaha | — | $28.4M | 10 |
| YMCA OF GREATER OMAHA | Omaha | P27Z Human Services | $28M | 5 |
| UNION COLLEGE | Lincoln | B420 Education | $28M | 6 |
| STEAMFITTERS AND PLUMBERS LOCAL 464 WELFARE FUND C/O BENESYS INC | Omaha | — | $27.8M | 0 |
| OUTLOOK-NEBRASKA INC | Omaha | J30 Employment | $27.1M | 5 |
| PROJECT HARMONY | Omaha | I80 Crime & Legal-Related | $26.8M | 7 |
| PACE NEBRASKA | Omaha | E19 Health Care | $26.8M | 9 |
| MONA REAL ESTATE HOLDINGS | Kearney | A11 Arts, Culture & Humanities | $25.9M | 0 |
| Cambridge Memorial Hospital Inc | Cambridge | E22I Health Care | $25.8M | 8 |
| BLUESTEM HEALTH | Lincoln | E30 Health Care | $24.3M | 9 |
| IMMANUEL LONG TERM CARE | Omaha | E91 Health Care | $24.1M | 9 |
| COLLEGE OF SAINT MARY | Omaha | B42Z Education | $23.9M | 6 |
| JOSLYN ART MUSEUM | Omaha | A510 Arts, Culture & Humanities | $23.8M | 5 |
| HIGHLANDER PHASE I QALICB INC | Omaha | — | $23.6M | 1 |
| OMNI BEHAVIORAL HEALTH | Omaha | T30Z Philanthropy, Voluntarism & Grantmaking Foundations | $23M | 7 |
| OMAHA CHILDREN'S TRUST | Omaha | A52 Arts, Culture & Humanities | $22.9M | 0 |
| NEBRASKA SOYBEAN BOARD | Lincoln | — | $22.5M | 0 |
| NEBRASKA ORGAN RECOVERY SYSTEM | Omaha | E65Z Health Care | $22.5M | 7 |
| CHILDREN'S HOSPITAL & MEDICAL CENTER FOUNDATION | Omaha | E112 Health Care | $22.4M | 2 |
| CHARLES DREW HEALTH CENTER INC | Omaha | E320 Health Care | $22.2M | 9 |
| HENDERSON HEALTH CARE SERVICES INC | Henderson | E22Z Health Care | $22.1M | 7 |
| FOUNDATION FOR EDUCATIONAL SERVICES | Lincoln | — | $21.9M | 20 |
| GOODWILL INDUSTRIES OF GREATER NEBRASKA INC | Grand Island | J32Z Employment | $21.6M | 1 |
| ANTELOPE MEMORIAL HOSPITAL | Neligh | E22Z Health Care | $21.5M | 7 |
| JENNIE MELHAM MEMORIAL MEDICAL CENTER INC | Broken Bow | E220 Health Care | $21.3M | 7 |
| OMAHA FIREFIGHTERS HEALTHCARE TRUST | Omaha | Y43 Mutual & Membership Benefit | $21.3M | 1 |
| MIDWEST HOUSING EQUITY GROUP INC | Omaha | L99Z Housing & Shelter | $20.7M | 10 |
| JUSTICE FOR OUR NEIGHBORS-NEBRASKA | Omaha | P80 Human Services | $20.4M | 7 |
| FOOD BANK OF LINCOLN INC | Lincoln | K31Z Food, Agriculture & Nutrition | $20.2M | 3 |
| National Strategic Research Institute | Lincoln | U05 Science & Technology | $20.2M | 17 |
| CHILD SAVING INSTITUTE FOUNDATION INC | Omaha | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $19.9M | 4 |
| CLARKSON REGIONAL HEALTH SERVICE INC | Omaha | E12 Health Care | $19.4M | 7 |
| Panhandle Rural Electric Membership Association | Alliance | — | $19.4M | 14 |
| YMCA OF LINCOLN | Lincoln | P27Z Human Services | $19.2M | 3 |
| PEOPLE'S CITY MISSION | Lincoln | L41Z Housing & Shelter | $19.2M | 3 |
| HALL COUNTY LIVESTOCK IMPROVEMENT A | Grand Island | — | $19M | 1 |
| WESTSIDE COMMUNITY SCHOOLS FOUNDATION INC | Omaha | B41I Education | $18.8M | 2 |
| YORK UNIVERSITY | York | B420 Education | $18.8M | 1 |
| D F DILLON FOUNDATION C/O JOSEPH KERRIGAN | Lincoln | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $18.4M | 4 |
| COMMUNITY ACTION PARTNERSHIP OF LANCASTER AND SAUNDERS COUNTIES | Lincoln | Z99Z Unknown | $18.4M | 5 |
