| ASCENSION BORGESS FOUNDATION | St Louis | — | $2.9M | 8 |
| LITERACY KANSAS CITY | Kansas City | — | $2.9M | 1 |
| St Vincent RAS Inc | St Louis | E21 Health Care | $2.9M | 3 |
| OZARKS ENVIRONMENTAL SERVICES INC | Kimberling City | C32 Environment | $2.9M | 3 |
| HORIZON CREDIT UNION | Macon | — | $2.9M | 1 |
| THE LEADERSHIP SCHOOL | St Louis | B29 Education | $2.9M | 1 |
| WESTPORT REGIONAL BUSINESS LEAGUE | Kansas City | S41 Community Improvement & Capacity Building | $2.9M | 1 |
| BRIDGING THE GAP INC | Kansas City | — | $2.9M | 1 |
| OPPENSTEIN BROTHERS FOUNDATION | Kansas City | — | $2.8M | 3 |
| CORNERSTONES OF CARE FOUNDATION | Kansas City | T30I Philanthropy, Voluntarism & Grantmaking Foundations | $2.8M | 3 |
| LYNNE AND OWEN BUCKLEY FOUNDATION | Kansas City | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $2.8M | 0 |
| WATERED GARDENS RESCUE MISSION | Joplin | P20 Human Services | $2.8M | 0 |
| NORTHLAND NEIGHBORHOODS INC | Kansas City | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $2.8M | 0 |
| MOSHIRI FAMILY FOUNDATION | St Louis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.8M | 0 |
| MUSSER-DAVIS LAND COMPANY | Kansas City | B54I Education | $2.8M | 9 |
| INVESTIGATIVE REPORTERS & EDITORS INC | Columbia | A33C Arts, Culture & Humanities | $2.8M | 1 |
| DUO DOGS INC | St Louis | — | $2.8M | 1 |
| MISSOURI COALITION AGAINST DOMESTIC AND | Jefferson City | — | $2.8M | 4 |
| Jennings Family Foundation The | Joplin | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.8M | 0 |
| MARION COUNTY SERVICES INC | Hannibal | — | $2.8M | 1 |
| UNITE HERE LOCAL 74 WELFARE AND DENTAL | St Louis | Y44 Mutual & Membership Benefit | $2.8M | 0 |
| NATIONAL ELECTRICAL CONTR ASSOC | St Louis | — | $2.8M | 3 |
| ELECTRICAL JOINT APPRENTICESHIP AND | Kansas City | — | $2.8M | 6 |
| MISSISSIPPI COUNTY INTERAGENCY | East Prairie | P200 Human Services | $2.8M | 1 |
| ENTREPRENEUR STARTUP BUSINESS | St Louis | S30 Community Improvement & Capacity Building | $2.8M | 2 |
| BREAST CANCER FOUNDATION OF THE | Springfield | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $2.8M | 3 |
| MIDWEST VETERANS' BIOMEDICAL RESEARCH | Kansas City | H99Z Medical Research | $2.8M | 2 |
| The H & R Block Foundation | Kansas City | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $2.8M | 1 |
| ANNA P SIROMAS CHARITABLE TRUST UAD 228201 | St Louis | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $2.8M | 1 |
| ST LOUIS GYMNASTIC CENTRE | St Louis | — | $2.8M | 1 |
| NATIONAL ASSOCIATION OF WORKFORCE | West Plains | S41 Community Improvement & Capacity Building | $2.8M | 1 |
| The Women's Safe House | St Louis | P430 Human Services | $2.8M | 1 |
| ST ELIZABETH ADULT DAY CARE CENTER | St Louis | P700 Human Services | $2.8M | 2 |
| ST JOSEPH AREA CHAMBER OF COMMERCE | Saint Joseph | — | $2.8M | 1 |
| Columbia Center for Urban Agriculture | Columbia | C40 Environment | $2.8M | 0 |
| JEFFERSON CITY CONVENTION AND | Jefferson City | S99 Community Improvement & Capacity Building | $2.8M | 1 |
| MISSOURI GIRLS TOWN FOUNDATION INC | Kingdom City | I440 Crime & Legal-Related | $2.8M | 2 |
| TW BGSM-GORDON GRAY TRUST | Saint Louis | — | $2.8M | 1 |
| BOYS & GIRLS CLUB OF JEFFERSON CITY | Jefferson City | O20Z Youth Development | $2.8M | 2 |
| CROWDER COLLEGE FOUNDATION INC | Neosho | B114 Education | $2.8M | 1 |
| AMERICAN MEAT SCIENCE ASSOCIATION | Kearney | U99Z Science & Technology | $2.8M | 3 |
| ADELE BRAUN CHARITABLE FOUNDATION | St Louis | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $2.8M | 0 |
| LAY FAMILY FOUNDATION | Warson Woods | — | $2.8M | 0 |
| SHAWMET HOMES INC | Kansas City | L20Z Housing & Shelter | $2.7M | 0 |
| KANSAS CITY MUSEUM FOUNDATION INC | Kansas City | A11 Arts, Culture & Humanities | $2.7M | 1 |
| GATEWAY TO HOPE | Maplewood | G99 Diseases, Disorders & Medical Disciplines | $2.7M | 2 |
| WEST CENTRAL COMMUNITY DEVELOPMENT | Appleton City | S30 Community Improvement & Capacity Building | $2.7M | 2 |
| ST LOUIS SHAKESPEARE FESTIVAL | St Louis | A65 Arts, Culture & Humanities | $2.7M | 1 |
| THE LORDI MARKER FAMILY FOUNDATION | Kansas City | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $2.7M | 0 |
| A MILLION STARS INC DBA COLLEGE BOUND | St Louis | O50 Youth Development | $2.7M | 1 |
