| PINELAND FARMS INC | New Gloucester | A80 Arts, Culture & Humanities | $9.7M | 5 |
| PINE TREE LEGAL ASSISTANCE INC | Portland | I80Z Crime & Legal-Related | $9.7M | 6 |
| SACO VALLEY CREDIT UNION | Saco | — | $9.7M | 4 |
| United Way Inc | Portland | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $9.5M | 4 |
| Sacopee Valley Health Center | Porter | E39Z Health Care | $9.4M | 7 |
| MILESTONE RECOVERY | Portland | F22Z Mental Health & Crisis Intervention | $9.4M | 2 |
| CENTRAL AROOSTOOK ASSOCIATION | Presque Isle | P820 Human Services | $9.3M | 2 |
| MIDCOAST MAINE COMMUNITY ACTION | Bath | P200 Human Services | $9.1M | 2 |
| J BLAIR & TENA FRANK FOUNDATION | Portland | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $9.1M | 0 |
| COMMUNITY CREDIT UNION | Lewiston | — | $9.1M | 1 |
| SKILLS INC | St Albans | P820 Human Services | $9.1M | 2 |
| PEREGRINE CORPORATION | South Portland | P820 Human Services | $9M | 4 |
| NORTHEAST HARBOR TENNIS CLUB | Northeast Harbor | — | $9M | 0 |
| WESTERN MAINE COMMUNITY ACTION INC | East Wilton | P200 Human Services | $8.9M | 2 |
| KahleAustin Foundation | Biddeford | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $8.9M | 0 |
| Home for the Aged | Portland | P750 Human Services | $8.8M | 3 |
| St Croix Regional Family Health Center | Princeton | E20Z Health Care | $8.7M | 8 |
| Quarry Hill | Belfast | E91Z Health Care | $8.6M | 5 |
| JOHN BAPST MEMORIAL HIGH SCHOOL | Bangor | B250 Education | $8.6M | 1 |
| HealthInfoNet | New Gloucester | W50 Public & Societal Benefit | $8.5M | 2 |
| ME CREDIT UNION LEAGUE INS TR | Westbrook | Y43 Mutual & Membership Benefit | $8.5M | 1 |
| Sebasticook Family Doctors | Newport | E30 Health Care | $8.2M | 7 |
| TRAVIS MILLS FOUNDATION | Mount Vernon | W30 Public & Societal Benefit | $8.2M | 4 |
| BIODIVERSITY RESEARCH INSTITUTE | Portland | C056 Environment | $8.2M | 2 |
| Bangor Nursing & Rehabilitation Center | Bangor | E91 Health Care | $8.2M | 6 |
| INITIATIVE FOR DIGITAL ENGINEERING AND LIFE SCIENCES | Falmouth | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $8.2M | 2 |
| Regional Medical Center at Lubec ME Inc | Lubec | E20Z Health Care | $8.2M | 7 |
| ANIMAL REFUGE LEAGUE OF GREATER PORTLAND | Westbrook | D200 Animal-Related | $8.1M | 1 |
| Chewonki Foundation Inc | Wiscasset | C600 Environment | $8M | 2 |
| WASHINGTON ACADEMY | East Machias | B25Z Education | $7.9M | 3 |
| Northern Light Medical Transport Northern Light Medical Transport & Emerg | Brewer | E200 Health Care | $7.9M | 12 |
| The Genesis Fund | Brunswick | X20J Religion-Related | $7.9M | 6 |
| Bowdoin International Music Festival | Brunswick | A680 Arts, Culture & Humanities | $7.9M | 3 |
| Southern Maine Agency on Aging | Biddeford | P81Z Human Services | $7.8M | 2 |
| COMMUNITY DENTAL | Portland | E34Z Health Care | $7.8M | 8 |
| Island Institute | Rockland | B82Z Education | $7.7M | 5 |
| OPPORTUNITY ENTERPRISES INC | Auburn | E60 Health Care | $7.7M | 1 |
| MAINE COALITION AGAINST SEXUAL ASSAULT | Augusta | — | $7.6M | 1 |
| Council on International Educational Exchange Inc | South Portland | Q230 International, Foreign Affairs & National Security | $7.5M | 9 |
| The Pasculano Foundation | Cape Elizabeth | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $7.5M | 0 |
| Carrabassett Valley Academy | Carrabassett Valley | B25Z Education | $7.5M | 3 |
| Portland Public Library | Portland | B71Z Education | $7.5M | 1 |
| Katahdin Friends Inc | Millinocket | P820 Human Services | $7.4M | 2 |
| LincolnHealth Medical Partners Inc | Damariscotta | E19 Health Care | $7.4M | 15 |
| Eastport Health Care Inc | Eastport | E320 Health Care | $7.4M | 7 |
| BRUNSWICK WALDORF SCHOOL ASSOCIATION | Freeport | B21Z Education | $7.3M | 5 |
| REVERB INC | Portland | C60 Environment | $7.2M | 2 |
| Alfond Scholarship Foundation | Portland | B82 Education | $7.2M | 1 |
| Young Men's Christian Association Boothbay Region | Boothbay Harbor | — | $7M | 2 |
| LEAP INC | Farmington | P820 Human Services | $7M | 1 |
