| DOWNEAST COMMUNITY PARTNERS INC | Ellsworth | P300 Human Services | $14.3M | 2 |
| PINE TREE SOCIETY INC | Bath | B28Z Education | $14.1M | 2 |
| Mount Desert Island Biological Laboratory | Salisbury Cove | U500 Science & Technology | $14.1M | 10 |
| AMERICAN SCHOOLS ABROAD INC c/o Petrucelli Martin & Haddow LLC | Portland | — | $13.9M | 3 |
| John T Gorman Foundation | Portland | T21J Philanthropy, Voluntarism & Grantmaking Foundations | $13.6M | 2 |
| Kieve Wavus Education Inc | Nobleboro | P99 Human Services | $13.6M | 6 |
| AVESTA HOUSING DEVELOPMENT CORPORATION | Portland | L210 Housing & Shelter | $13.5M | 6 |
| United Cerebral Palsy of Northeastern Maine | Bangor | G23Z Diseases, Disorders & Medical Disciplines | $13.4M | 2 |
| OGUNQUIT PLAYHOUSE FOUNDATION | Ogunquit | A110 Arts, Culture & Humanities | $13.3M | 3 |
| BUCKSPORT REGIONAL HEALTH CENTER | Bucksport | E39Z Health Care | $13.3M | 9 |
| Group Main Stream Incorporated | Westbrook | — | $13.1M | 1 |
| Maine Affordable Energy | Portland | — | $13.1M | 1 |
| THE WOODLANDS CLUB | Falmouth | — | $13.1M | 7 |
| MAINE CHILDREN'S TRUST | Augusta | I120 Crime & Legal-Related | $12.9M | 1 |
| Lakewood Northern Light Continuing Care Lakewood | Waterville | E200 Health Care | $12.8M | 12 |
| Coastal Maine Botanical Gardens Inc | Boothbay | C410 Environment | $12.8M | 4 |
| Mid Coast Geriatric Services Corporation | Brunswick | E20 Health Care | $12.7M | 16 |
| St Andre Health Care Facility | Biddeford | — | $12.4M | 6 |
| JHA ASSISTED LIVING INC | Portland | L22 Housing & Shelter | $12.2M | 8 |
| Maine Central Institute | Pittsfield | B250 Education | $12M | 2 |
| BANGOR YOUNG MEN'S CHRISTIAN ASSOCIATION | Bangor | P270 Human Services | $11.9M | 2 |
| Hyde School | Bath | B25Z Education | $11.8M | 6 |
| MAINE COALITION TO END DOMESTIC VIOLENCE | Augusta | P43Z Human Services | $11.8M | 1 |
| Independence Association Inc | Brunswick | P820 Human Services | $11.5M | 1 |
| FOXCROFT ACADEMY TRUSTEES OF | Doverfoxcroft | B24Z Education | $11.3M | 3 |
| LINCOLN ACADEMY | New Castle | B250 Education | $11.2M | 2 |
| Community Health and Nursing Services | Brunswick | E90Z Health Care | $11.1M | 16 |
| Sunrise Opportunities | Machias | F33Z Mental Health & Crisis Intervention | $10.9M | 1 |
| DECOSTER FAMILY CHARITABLE FOUNDATION INC | Turner | X12 Religion-Related | $10.9M | 0 |
| AVESTA HOUSING MANAGEMENT CORPORATION | Portland | L20 Housing & Shelter | $10.9M | 6 |
| Alternative Services - Northeast Inc | Auburn | P75Z Human Services | $10.8M | 8 |
| FAMILY PLANNING ASSOCIATION OF MAINE INC | Augusta | E42 Health Care | $10.6M | 3 |
| United Ambulance Service | Lewiston | E62 Health Care | $10.6M | 6 |
| Boys & Girls Clubs of Southern Maine | Portland | O210 Youth Development | $10.6M | 1 |
| Eastern Maine Development Corporation | Bangor | S300 Community Improvement & Capacity Building | $10.5M | 0 |
| Seventy-Five State Street | Portland | L22Z Housing & Shelter | $10.5M | 2 |
| DFD RUSSELL MEDICAL CENTER INC | Leeds | — | $10.5M | 13 |
| COMMUNITY LIVING ASSOCIATION | Houlton | P820 Human Services | $10.2M | 0 |
| LINCOLNHEALTH COVE'S EDGE | Damariscotta | E910 Health Care | $10.2M | 15 |
| Northern Maine Development Commission | Caribou | S30Z Community Improvement & Capacity Building | $10.2M | 1 |
| Bridgton Academy | North Bridgton | B31Z Education | $10.1M | 4 |
| Open Library of Richmond Inc | Biddeford | B05 Education | $10.1M | 0 |
| Community Care | Bangor | P32 Human Services | $10M | 1 |
| Downeast Horizons Inc | Ellsworth | F80 Mental Health & Crisis Intervention | $10M | 1 |
| ERSKINE ACADEMY | South China | B25Z Education | $9.9M | 1 |
| MAINE EDUCATION ASSOCIATION | Augusta | — | $9.9M | 28 |
| Maine Seacoast Mission | Northeast Harbor | — | $9.8M | 2 |
| DELTA AMBULANCE | Waterville | E62Z Health Care | $9.8M | 6 |
| Independence Advocates of Maine Inc | Orono | P700 Human Services | $9.7M | 1 |
| Wolfe's Neck Farm Foundation | Freeport | T30Z Philanthropy, Voluntarism & Grantmaking Foundations | $9.7M | 2 |
