| BIG BROTHERS BIG SISTERS | Saint Louis | — | $6.3M | 5 |
| GOETZ CREDIT UNION | St Joseph | — | $6.3M | 3 |
| MEDS & FOOD FOR KIDS | St Louis | Q33 International, Foreign Affairs & National Security | $6.2M | 1 |
| OPERATING ENGINEERS LOCAL 101 | Kansas City | — | $6.2M | 1 |
| BOARD OF TRUSTEES SOUTHERN ILLINOIS | St Louis | — | $6.2M | 0 |
| Mothers Refuge | Independence | P450 Human Services | $6.2M | 1 |
| UNITED SOCCER COACHES ASSOCIATION | Kansas City | N99Z Recreation & Sports | $6.2M | 5 |
| MISSOURI CORN MERCHANDISING COUNCIL | Jefferson City | — | $6.2M | 1 |
| Youth Passageways | Kansas City | P30 Human Services | $6.2M | 3 |
| NORTHEAST MISSOURI COMMUNITY ACTION | Kirksville | — | $6.2M | 2 |
| IBEW-NECA SERVICE CENTER INC | St Louis | — | $6.1M | 1 |
| Landmark Legal Foundation | Kansas City | I83Z Crime & Legal-Related | $6.1M | 4 |
| OPERATING ENGINEERS LOCAL 513 | Silex | J22Z Employment | $6.1M | 2 |
| Pershing Charitable Trust | St Louis | — | $6.1M | 1 |
| BOYS & GIRLS CLUB OF POPLAR BLUFF | Poplar Bluff | O23 Youth Development | $6.1M | 0 |
| MID-AMERICA CARPENTERS REGIONAL BENEFITS | St Louis | J19 Employment | $6.1M | 0 |
| CORE INFLUENCER INSTITUTE INC | Kansas City | B99 Education | $6.1M | 0 |
| Big Brothers Big Sisters Kansas City | Kansas City | — | $6.1M | 5 |
| DOGS ON DUTY | Saint Peters | D99 Animal-Related | $6.1M | 3 |
| FV SERVICES INC | St Louis | L02 Housing & Shelter | $6.1M | 18 |
| NEW FLORENCE NURSING HOME | St Louis | — | $6.1M | 3 |
| LYRIC OPERA OF KANSAS CITY INC | Kansas City | A6A0 Arts, Culture & Humanities | $6.1M | 2 |
| THE NATIONAL CATHOLIC REPORTER PUBLISHING CO | Kansas City | X830 Religion-Related | $6.1M | 5 |
| Lafayette Preparatory Academy Inc | St Louis | B29 Education | $6.1M | 1 |
| Little Sisters of The Poor | Kansas City | P750 Human Services | $6.1M | 1 |
| INTERNATIONAL CRISIS AID INC | St Louis | P33 Human Services | $6M | 3 |
| COMMUNITY FOUNDATION OF CENTRAL MO | Columbia | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $6M | 0 |
| COMMUNITY NEWS FOUNDATION | Harrisonville | W01 Public & Societal Benefit | $6M | 1 |
| THE COMMUNITY FOUNDATION OF NORTHWEST MISSOURIINC | Saint Joseph | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $6M | 2 |
| Dennis M Jones Family Foundation | St Louis | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $6M | 0 |
| SHEPARD MCCASKILL FOUNDATION | St Louis | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $6M | 0 |
| AFTER THE HARVEST | Kansas City | — | $6M | 1 |
| SERENITY HOSPICECARE | Park Hills | — | $6M | 0 |
| LIFE360 COMMUNITY SERVICES | Springfield | O20 Youth Development | $6M | 5 |
| UNITED INNER CITY SERVICES INC | Kansas City | P200 Human Services | $6M | 3 |
| LaCoba Homes Inc | Monett | — | $5.9M | 1 |
| MATTIE RHODES MEMORIAL SOCIETY | Kansas City | F320 Mental Health & Crisis Intervention | $5.9M | 1 |
| PULITZER ARTS FOUNDATION | St Louis | S21Z Community Improvement & Capacity Building | $5.9M | 2 |
| MISSOURI BAPTIST HEALTHCARE FOUNDATION | St Louis | E11 Health Care | $5.9M | 2 |
| HILLCREST MINISTRIES OF MIDAMERICA | Kansas City | P85 Human Services | $5.9M | 2 |
| Fitzgibbon Health Services | Marshall | E91 Health Care | $5.9M | 4 |
| METRO CREDIT UNION | Springfield | — | $5.9M | 2 |
| ACADEMY FOR INTEGRATED ARTS | Kansas City | B29 Education | $5.9M | 1 |
| GOWER CONVALESCENT CENTER INC | Gower | E91Z Health Care | $5.9M | 1 |
| KANSAS CITY AREA DEVELOPMENT COUNCIL | Kansas City | S41 Community Improvement & Capacity Building | $5.9M | 10 |
| MONETA GROUP LLC EMPLOYEE | Clayton | Y43 Mutual & Membership Benefit | $5.9M | 0 |
| DELLA LAMB COMMUNITY SERVICES | Kansas City | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $5.9M | 2 |
| CASCO AREA WORKSHOP INC | Harrisonville | — | $5.9M | 0 |
| THE REPERTORY THEATRE OF ST LOUIS | Saint Louis | A650 Arts, Culture & Humanities | $5.8M | 2 |
| KANSAS CITY REPERTORY THEATRE INC | Kansas City | A650 Arts, Culture & Humanities | $5.8M | 2 |
