| MHA Health Institute | Jefferson City | — | $5.8M | 2 |
| JEFFERSON NATIONAL PARKS ASSOCIATION | St Louis | A82Z Arts, Culture & Humanities | $5.8M | 4 |
| Alexian Brothers Center for Mental Health | St Louis | F30Z Mental Health & Crisis Intervention | $5.8M | 5 |
| NORTHEAST INDEPENDENT LIVING SERVICES | Hannibal | Z99 Unknown | $5.8M | 0 |
| FAMILY AND WORKFORCE CENTERS OF AMERICA | St Louis | P02 Human Services | $5.8M | 5 |
| THE HARRY S TRUMAN LIBRARY INSTITUTE NATIONAL AND INTERNATIONAL AFFAIRS | Kansas City | B50 Education | $5.8M | 2 |
| METROPOLITAN COMMUNITY COLLEGE BUILDING CORPORATION | Kansas City | B110 Education | $5.8M | 3 |
| THE COUNTRY CLUB OF MISSOURI | Columbia | — | $5.8M | 0 |
| LIFE CHRISTIAN OUTREACH INC | Columbia | A33Z Arts, Culture & Humanities | $5.7M | 2 |
| CHAMBER OF COMMERCE OF GREATER KANSAS CITY | Kansas City | — | $5.7M | 8 |
| SAINT LOUIS COUNSELING INC | Fenton | — | $5.7M | 4 |
| FUND FOR ISRAEL'S TOMORROW | St Louis | Q123 International, Foreign Affairs & National Security | $5.7M | 1 |
| NEGRO LEAGUES BASEBALL MUSEUM INC | Kansas City | A500 Arts, Culture & Humanities | $5.7M | 0 |
| PLUMBERS UNION 178 HEALTH & WELFARE & APPRENTICESHIP TRUST | Springfield | — | $5.7M | 0 |
| THE CEDARS CAMPS INC | Ballwin | — | $5.7M | 2 |
| ASCENSION VIA CHRISTI PROPERTY SERVICES INC | St Louis | — | $5.7M | 3 |
| Saint Thomas Network | St Louis | E110 Health Care | $5.6M | 9 |
| MIDWEST ASSISTANCE PROGRAM INC | Maryville | — | $5.6M | 3 |
| MISSOURI JOBS WITH JUSTICE | St Louis | J40 Employment | $5.6M | 1 |
| Developing Potential Inc | Lees Summit | J220 Employment | $5.6M | 1 |
| WARREN COUNTY PATHFINDERS | Warrenton | P82Z Human Services | $5.6M | 0 |
| THE CENTER FOR AUTISM EDUCATION | St Peters | B28 Education | $5.6M | 1 |
| THE WYMAN CENTER | Eureka | N20Z Recreation & Sports | $5.6M | 6 |
| MISSOURI BAPTIST CHILDREN'S HOME | Bridgeton | X99 Religion-Related | $5.6M | 3 |
| INTERNATIONAL BROTHERHOOD OF 41 TCWH | Kansas City | — | $5.6M | 7 |
| BETTER BUSINESS BUREAU OF GREATER ST LOUIS INC | St Louis | — | $5.6M | 6 |
| SACRED HEART FOUNDATION INC | St Louis | E22I Health Care | $5.5M | 6 |
| THE WILLIAM R ORTHWEIN JR AND LAURA RAND ORTHWEIN FOUNDATION INC | St Louis | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $5.5M | 1 |
| CHESTERFIELD HOCKEY ASSOCIATION | Chesterfield | N68Z Recreation & Sports | $5.5M | 3 |
| ECONOMIC DEVELOPMENT CORPORATION OF KANSAS CITY MISSOURI | Kansas City | — | $5.5M | 6 |
| RAPHA HOUSE INTERNATIONAL INC | Joplin | I72 Crime & Legal-Related | $5.5M | 0 |
| VARIETY THE CHILDRENS CHARITY OF ST LOUIS | Saint Louis | — | $5.5M | 2 |
| SSM HEALTH FOUNDATION - ST LOUIS | St Louis | — | $5.5M | 10 |
| HELPING HAND OF GOODWILL INDUSTRIES EXT EMP SHELTERED WORKSHOP | Kansas City | — | $5.5M | 6 |
| MOBILIZATION OPTIMIZATION STABILIZATION & TRAINING TRUST | Kansas City | — | $5.5M | 5 |
| MISSOURI CONSERVATION HERITAGE FOUNDATION | Jefferson City | C600 Environment | $5.5M | 1 |
| TEN TALENTS FOUNDATION | St Louis | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $5.4M | 2 |
| Moms for America Inc | Branson | P20 Human Services | $5.4M | 3 |
| GRAND RIVER AREA FAMILY YMCA INC | Chillicothe | — | $5.4M | 3 |
| AGRICULTURE FUTURE OF AMERICA | Kansas City | O52 Youth Development | $5.4M | 2 |
| MISSOURI FARM BUREAU FEDERATION | Jefferson City | — | $5.4M | 19 |
| MISSOURI SOYBEAN ASSOCIATION | Jefferson City | — | $5.4M | 6 |
| DE LA SALLE EDUCATION CENTER | Kansas City | — | $5.4M | 1 |
| BRIDGE STRUCTURAL & ORNAMENTAL IRON WORKERS INTL ASSN LOCAL 10 | Kansas City | — | $5.4M | 17 |
| NEW HAVEN CARE CENTER INC | New Haven | — | $5.4M | 1 |
| JOBONE | Independence | — | $5.4M | 1 |
| CENTER OF CREATIVE ARTS | Saint Louis | A20Z Arts, Culture & Humanities | $5.4M | 4 |
| CITYSERVE INTERNATIONAL | Springfield | A23 Arts, Culture & Humanities | $5.4M | 3 |
| EVERETT AND GENEVA SUGARBAKER FOUNDATION | Saint Louis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.4M | 0 |
| HEYMAN-DAIGLE FAMILY FOUNDATION | St Louis | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.4M | 0 |
