| NORTHEAST MISSOURI COMMUNITY ACTION AGENCY | Kirksville | — | $6.2M | 2 |
| CATHOLIC CHARITIES OF THE ARCHDIOCESE OF ST LOUIS | St Louis | P20Z Human Services | $6.1M | 7 |
| IBEW-NECA SERVICE CENTER INC | St Louis | — | $6.1M | 1 |
| Landmark Legal Foundation | Kansas City | I83Z Crime & Legal-Related | $6.1M | 4 |
| OPERATING ENGINEERS LOCAL 513 JOURNEYMEN & APPRENTICESHIP TRAINING FND | Silex | J22Z Employment | $6.1M | 2 |
| Pershing Charitable Trust | St Louis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $6.1M | 1 |
| BOYS & GIRLS CLUB OF POPLAR BLUFF | Poplar Bluff | O23 Youth Development | $6.1M | 0 |
| CORE INFLUENCER INSTITUTE INC | Kansas City | B99 Education | $6.1M | 0 |
| DOGS ON DUTY | Saint Peters | D99 Animal-Related | $6.1M | 3 |
| FV SERVICES INC | St Louis | L02 Housing & Shelter | $6.1M | 18 |
| NEW FLORENCE NURSING HOME | St Louis | — | $6.1M | 3 |
| Missouri Co-Operative Employee Health Care Fund | Richmond | — | $6.1M | 0 |
| THE NATIONAL CATHOLIC REPORTER PUBLISHING CO | Kansas City | X830 Religion-Related | $6.1M | 5 |
| Lafayette Preparatory Academy Inc | St Louis | B29 Education | $6.1M | 1 |
| EMPLOYMENT CONNECTION | St Louis | — | $6.1M | 3 |
| INTERNATIONAL CRISIS AID INC | St Louis | P33 Human Services | $6M | 3 |
| UNIVERSITY OF MISSOURI LAW SCHOOL FOUNDATION | Columbia | — | $6M | 1 |
| COMMUNITY NEWS FOUNDATION | Harrisonville | W01 Public & Societal Benefit | $6M | 1 |
| SACRED HEART FOUNDATION INC | St Louis | E22I Health Care | $6M | 4 |
| SHEPARD MCCASKILL FOUNDATION C/O ARGOS FAMILY OFFICE LLC | St Louis | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $6M | 0 |
| SERENITY HOSPICECARE | Park Hills | — | $6M | 0 |
| MIDWEST ASSISTANCE PROGRAM INC | Maryville | — | $6M | 2 |
| MISSOURI HUMANITIES COUNCIL | Kansas City | A700 Arts, Culture & Humanities | $5.9M | 1 |
| LaCoba Homes Inc | Monett | — | $5.9M | 1 |
| MATTIE RHODES MEMORIAL SOCIETY D/B/A MATTIE RHODES CENTER | Kansas City | F320 Mental Health & Crisis Intervention | $5.9M | 1 |
| MOBILIZATION OPTIMIZATION STABILIZATION & TRAINING TRUST | Kansas City | — | $5.9M | 4 |
| HILLCREST MINISTRIES OF MIDAMERICA | Kansas City | P85 Human Services | $5.9M | 2 |
| Fitzgibbon Health Services | Marshall | E91 Health Care | $5.9M | 4 |
| STEPHEN MINISTRIES | Saint Louis | X21B Religion-Related | $5.9M | 4 |
| ACADEMY FOR INTEGRATED ARTS | Kansas City | B29 Education | $5.9M | 1 |
| BETTER BUSINESS BUREAU OF GREATER ST LOUIS INC | St Louis | — | $5.9M | 6 |
| MONETA GROUP LLC EMPLOYEE BENEFITS PLAN TRUST | Clayton | Y43 Mutual & Membership Benefit | $5.9M | 0 |
| THE REPERTORY THEATRE OF ST LOUIS | Saint Louis | A650 Arts, Culture & Humanities | $5.8M | 2 |
| MHA Health Institute | Jefferson City | — | $5.8M | 2 |
| Rolling Hills Creative Living Inc | Albany | P82Z Human Services | $5.8M | 1 |
| ELECTRICAL APPARATUS SERVICE ASSOCIATION INC | St Louis | — | $5.8M | 6 |
| Developing Potential Inc | Lees Summit | J220 Employment | $5.8M | 1 |
| FAMILY AND WORKFORCE CENTERS OF AMERICA | St Louis | P02 Human Services | $5.8M | 5 |
| THE HARRY S TRUMAN LIBRARY INSTITUTE NATIONAL AND INTERNATIONAL AFFAIRS | Kansas City | B50 Education | $5.8M | 2 |
| METROPOLITAN COMMUNITY COLLEGE BUILDING CORPORATION | Kansas City | B110 Education | $5.8M | 3 |
| THE COUNTRY CLUB OF MISSOURI | Columbia | — | $5.8M | 0 |
| LIFE CHRISTIAN OUTREACH INC | Columbia | A33Z Arts, Culture & Humanities | $5.7M | 2 |
| PLUMBERS UNION 178 HEALTH & WELFARE & APPRENTICESHIP TRUST | Springfield | — | $5.7M | 0 |
| JEFFERSON NATIONAL PARKS ASSOCIATION | St Louis | A82Z Arts, Culture & Humanities | $5.7M | 4 |
| CHAMBER OF COMMERCE OF GREATER KANSAS CITY | Kansas City | — | $5.7M | 8 |
| FUND FOR ISRAEL'S TOMORROW | St Louis | Q123 International, Foreign Affairs & National Security | $5.7M | 1 |
| INTERNATIONAL BROTHERHOOD OF 41 TCWH | Kansas City | — | $5.7M | 7 |
| THE CEDARS CAMPS INC | Ballwin | — | $5.7M | 2 |
| MISSOURI JOBS WITH JUSTICE | St Louis | J40 Employment | $5.6M | 1 |
| STOWERS REAL ESTATE HOLDING CORPORATION | Kansas City | S47 Community Improvement & Capacity Building | $5.6M | 3 |
