| NEWHOUSE INC | Kansas City | Z99Z Unknown | $5.4M | 1 |
| Encounter Ministry Inc | Roach | X99 Religion-Related | $5.3M | 1 |
| SAINT THOMAS HEALTH FOUNDATIONS | St Louis | — | $5.3M | 6 |
| AREA AGENCY ON AGING REGION X | Joplin | P81 Human Services | $5.3M | 3 |
| LABORERS UNION LOCAL 110 | St Louis | — | $5.3M | 9 |
| Missouri Prairie Foundation | Columbia | C340 Environment | $5.3M | 1 |
| CATHOLIC CHARITIES OF ST LOUIS | St Louis | P20Z Human Services | $5.3M | 6 |
| MISSOURI SOUTHERN FOUNDATION | Joplin | B42I Education | $5.3M | 0 |
| Shelter KC | Kansas City | L410 Housing & Shelter | $5.3M | 1 |
| VOLT CREDIT UNION | Springfield | — | $5.3M | 3 |
| BURRELL-PREFERRED INC | Springfield | E60 Health Care | $5.3M | 9 |
| GATEWAY GLOBAL AMERICAN YOUTH & BUSINESS ALLIANCE INC | Saint Louis | B01 Education | $5.3M | 0 |
| OPERATING ENGINEERS LOCAL NO 101 | Platte City | — | $5.3M | 6 |
| STEPHEN MINISTRIES | Saint Louis | X21B Religion-Related | $5.3M | 4 |
| NEW HEIGHTS CHRISTIAN ACADEMY | Joplin | B200 Education | $5.3M | 0 |
| YOUNG AT HEART RESOURCES | Albany | — | $5.3M | 2 |
| THE STEPHEN F & CAMILLA T BRAUER | Chesterfield | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $5.3M | 0 |
| WILLIAM P INGERSOLL TRUST C | Clayton | O19 Youth Development | $5.3M | 1 |
| SPAY & NEUTER KANSAS CITY | Kansas City | D20 Animal-Related | $5.3M | 1 |
| WILLIAM T KEMPER CHARITABLE TRUST 10015200 | Kansas City | — | $5.2M | 2 |
| Missouri Co-Operative Employee | Richmond | — | $5.2M | 0 |
| St Vincent's Medical Center | St Louis | E220 Health Care | $5.2M | 3 |
| CATHOLIC CHARITIES FOUNDATION | St Louis | — | $5.2M | 5 |
| CHILDRENS SMILE CENTER CSC | Ozark | E32 Health Care | $5.2M | 1 |
| LUTHERAN SENIOR SERVICES ENDOWMENT FUND | St Louis | — | $5.2M | 19 |
| ELECTRICAL APPARATUS SERVICE ASSOCIATION | Saint Louis | — | $5.2M | 6 |
| LOGOS INC | St Louis | B28 Education | $5.2M | 2 |
| SHIRKEY DIVERSIFIED HEALTH SERVICES | Richmond | E91 Health Care | $5.2M | 1 |
| GREENE COUNTY AGRICULTURAL AND | Springfield | — | $5.2M | 3 |
| FEED MY PEOPLE | Saint Louis | P600 Human Services | $5.2M | 2 |
| Operation BBQ Relief | Peculiar | P60 Human Services | $5.1M | 10 |
| AAIM MANAGEMENT SERVICES | St Louis | S41 Community Improvement & Capacity Building | $5.1M | 9 |
| THE WILSON SCHOOL | St Louis | B250 Education | $5.1M | 1 |
| STAGES ST LOUIS | Chesterfield | — | $5.1M | 2 |
| OUR LADY OF LIFE APARTMENTS | St Louis | P750 Human Services | $5.1M | 3 |
| THOMAS JEFFERSON INDEP DAY SCHOOL | Joplin | B20Z Education | $5.1M | 1 |
| RISE COMMUNITY SERVICES | Warrensburg | P80 Human Services | $5.1M | 2 |
| ORTHOPEDIC FOUNDATION FOR ANIMALS | Columbia | — | $5.1M | 1 |
| Rolling Hills Creative Living Inc | Albany | P82Z Human Services | $5.1M | 1 |
| JEFFERSON CITY COUNTRY CLUB | Jefferson City | — | $5.1M | 1 |
| FATHERS SUPPORT CENTER ST LOUIS | Saint Louis | P40 Human Services | $5.1M | 4 |
| COMMUNITY SERVICES INC | Maryville | — | $5.1M | 1 |
| UNITED IN CRISIS INC | Odessa | M20 Public Safety, Disaster Preparedness & Relief | $5.1M | 2 |
| LUTHER MANOR ASSOCIATION | Hannibal | — | $5.1M | 0 |
| ST LOUIS SHEET METAL JOINT | St Louis | — | $5.1M | 4 |
| TRUMAN HERITAGE HABITAT FOR | Independence | — | $5.1M | 1 |
| GENETIC AUTISM ALLIANCE | Jefferson City | T01 Philanthropy, Voluntarism & Grantmaking Foundations | $5M | 0 |
| THE CARLOS & MARGUERITE MASON FDN | Saint Louis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5M | 1 |
| FIRST FRUITS OF ZION INC | Marshfield | X99Z Religion-Related | $5M | 4 |
| AcruxKC | Kansas City | E11 Health Care | $5M | 1 |
