| SOUTH CAROLINA ASSOCIATION OF COMMUNITY ACTION PARTNERSHIPS | Columbia | — | $7.3M | 3 |
| OPPORTUNITY SOUTH CAROLINA | Greenville | S30 Community Improvement & Capacity Building | $7.3M | 0 |
| CAROLINA VOYAGER CHARTER SCHOOL | Charleston | B99 Education | $7.3M | 1 |
| YMCA OF COASTAL CAROLINA | Myrtle Beach | P27Z Human Services | $7.2M | 3 |
| NEW MORNING | Columbia | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $7.2M | 1 |
| EAST COOPER MONTESSORI CHARTER SCHOOL | Mount Pleasant | B29 Education | $7.2M | 2 |
| Prisma Health-Upstate Foundation | Greenville | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $7.1M | 0 |
| TNKV FOUNDATION | Hilton Head Island | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $7.1M | 0 |
| LEGION COLLEGIATE ACADEMY | Rock Hill | B29 Education | $7.1M | 0 |
| LINCOLN TUBMAN FOUNDATION | Mt Pleasant | P62 Human Services | $7.1M | 1 |
| FRANCIS MARION UNIVERSITY | Florence | B19 Education | $7.1M | 2 |
| FLORENCE COUNTY COMMISSION ON ALCOH | Florence | F20Z Mental Health & Crisis Intervention | $7.1M | 1 |
| UNIVERSITY OF SOUTH CAROLINA | Columbia | B110 Education | $7M | 7 |
| CATAWBA REGIONAL COUNCIL | Rock Hill | S310 Community Improvement & Capacity Building | $7M | 1 |
| MILLIKEN & COMPANY CHARITABLE FOUNDATION | Spartanburg | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $7M | 0 |
| PRIMARY CARE ASSOCIATION OF SC INC | Columbia | E21Z Health Care | $7M | 4 |
| LOWCOUNTRY COMMUNITY ACTION AGENCY | Walterboro | S200 Community Improvement & Capacity Building | $7M | 0 |
| CHESTERFIELD-MARLBORO COUNTIES ECONOMIC | Cheraw | J22Z Employment | $7M | 0 |
| DARLINGTON COUNTY COMMUNITY ACTION | Hartsville | P20 Human Services | $7M | 0 |
| South Carolina Community Loan Fund | Charleston | L99 Housing & Shelter | $6.9M | 5 |
| CURIS FINANCIAL CREDIT UNION | Columbia | — | $6.9M | 1 |
| HILTON HEAD REGIONAL HABITAT FOR | Bluffton | L210 Housing & Shelter | $6.8M | 1 |
| TRI-COUNTY TECHNICAL COLLEGE | Pendleton | B43I Education | $6.8M | 0 |
| MASON PREPARATORY SCHOOL | Charleston | B24Z Education | $6.8M | 3 |
| CONGRESSIONAL MEDAL OF HONOR | Mount Pleasant | W30 Public & Societal Benefit | $6.7M | 5 |
| WILLIAMSBURG REGIONAL HOSPITAL | Kingstree | E22 Health Care | $6.7M | 4 |
| SECOND HELPINGS | Hilton Head Island | P99Z Human Services | $6.7M | 0 |
| Mental Illness Recovery Center Inc | Columbia | — | $6.7M | 3 |
| INSTITUTE FOR CHILD SUCCESS INC | Greenville | V23 Social Science | $6.7M | 8 |
| GREENVILLE TECHNICAL CHARTER HIGH SCHOOL | Greenville | B25 Education | $6.6M | 0 |
| GREER MIDDLE COLLEGE CHARTER HIGH SCHOOL | Taylors | B29 Education | $6.6M | 1 |
| NCEES FOUNDATION | Greenville | U42 Science & Technology | $6.6M | 3 |
| SOUTH CAROLINA HIGH SCHOOL LEAGUE | Columbia | — | $6.6M | 4 |
| The Country Club of Spartanburg | Spartanburg | N51Z Recreation & Sports | $6.6M | 4 |
| SOUTHEAST COASTAL OCEAN OBSERVING | Charleston | S40 Community Improvement & Capacity Building | $6.6M | 1 |
| SOUTH CAROLINA SCHOOL BOARDS | Columbia | B11 Education | $6.6M | 6 |
| SELF INSURANCE INSTITUTE | Simpsonville | — | $6.5M | 0 |
| GREENVILLE FREE MEDICAL CLINIC INC | Greenville | — | $6.5M | 1 |
| UNITED WAY ASSOCIATION OF SOUTH | Columbia | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $6.5M | 1 |
| SC Thrive | Columbia | U19 Science & Technology | $6.5M | 3 |
| South Carolina Educational Credit for | Columbia | B82 Education | $6.5M | 0 |
| COLUMBIA MUSEUM OF ART | Columbia | A510 Arts, Culture & Humanities | $6.5M | 3 |
| ORANGEBURG CONSOLIDATED SCHOOL DISTICT 5 | Orangeburg | B29 Education | $6.4M | 1 |
| HOME BUILDERS ASSOCIATION OF SOUTH | Columbia | Y20 Mutual & Membership Benefit | $6.4M | 0 |
| BEAUFORT MEMORIAL HOSPITAL FOUNDATION | Beaufort | E22I Health Care | $6.4M | 0 |
| SOUTHEASTERN HOUSING AND COMMUNITY | Barnwell | L80 Housing & Shelter | $6.4M | 0 |
| CULTURAL AND HERITAGE COMMISSION | Rock Hill | A500 Arts, Culture & Humanities | $6.4M | 1 |
| CLEMSON UNIVERSITY LAND STEWARDSHIP | Clemson | B11 Education | $6.3M | 0 |
| WACHESAW PLANTATION CLUB INC | Murrells Inlet | — | $6.3M | 0 |
| Oliver Gospel Mission | Columbia | X20 Religion-Related | $6.3M | 5 |
