| CLARENDON COUNTY DISABILITIES AND SPECIA | Manning | P820 Human Services | $9.4M | 1 |
| ROBERT S CAMPBELL FOUNDATION | Greenville | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $9.4M | 1 |
| THE VOLUNTEERS IN MEDICINE CLINIC | Hilton Head Island | — | $9.4M | 2 |
| SOUTH CAROLINA WATERFOWL ASSOCIATION | Pinewood | C320 Environment | $9.3M | 2 |
| FOX CREEK HIGH SCHOOL INC | North Augusta | B29 Education | $9.3M | 3 |
| WILDS CHRISTIAN ASSOCIATION INC | Taylors | N20Z Recreation & Sports | $9.2M | 5 |
| WILSON HALL | Sumter | B24Z Education | $9.1M | 1 |
| THE SOUTH CAROLINA BAR FOUNDATION | Columbia | I128 Crime & Legal-Related | $9.1M | 1 |
| DRS BRUCE & LEE FOUNDATION | Florence | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $9M | 11 |
| POLARIS TECH CHARTER SCHOOL | Ridgeland | B29 Education | $9M | 2 |
| KERSHAW COUNTY PUBLIC SCHOOLS | Camden | B11 Education | $9M | 2 |
| Upward Unlimited | Spartanburg | O55 Youth Development | $8.9M | 7 |
| PIEDMONT COMMUNITY ACTIONS INC | Spartanburg | P20Z Human Services | $8.7M | 1 |
| LITTLE RIVER WATER AND SEWERAGE COMPANY | Conway | W80Z Public & Societal Benefit | $8.7M | 10 |
| Chester-Lancaster Disabilities & Special Needs Boa | Lancaster | P82Z Human Services | $8.6M | 1 |
| Marion-Dillon Disabilities and | Dillon | P820 Human Services | $8.6M | 1 |
| DARNALL W AND SUSAN F BOYD FOUNDATION | Columbia | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $8.5M | 8 |
| TRIDENT AREA AGENCY ON AGING | Charleston | P81Z Human Services | $8.5M | 1 |
| CHARLESTON COLLEGIATE SCHOOL | Johns Island | — | $8.4M | 4 |
| RIVERBANKS SOCIETY | Columbia | D115 Animal-Related | $8.3M | 0 |
| AIKENBARNWELL CO CAA INC | Aiken | — | $8.2M | 1 |
| CHARLESTON DAY SCHOOLINC | Charleston | B240 Education | $8.2M | 1 |
| HABITAT FOR HUMANITY OF GREENVILLE | Greenville | L20Z Housing & Shelter | $8.2M | 1 |
| CAROLINA COMMUNITY CARE INC | Rock Hill | — | $8.1M | 4 |
| FOOTLIGHT PLAYERS INC | Charleston | A650 Arts, Culture & Humanities | $8.1M | 1 |
| RIVERWALK ACADEMY INC | Rock Hill | B28 Education | $8.1M | 1 |
| BREEZY HILL WATER AND SEWER CO | Graniteville | — | $8.1M | 1 |
| VIRTUS ACADEMY OF SOUTH CAROLINA | Florence | W99 Public & Societal Benefit | $8M | 1 |
| WILLIAMSBURG TECHNICAL COLLEGE FOUNDATION INC | Kingstree | B32I Education | $8M | 0 |
| PICKENS COUNTY YMCA | Easley | — | $7.9M | 1 |
| OCEANSIDE COLLEGIATE ACADEMY | Mount Pleasant | B29 Education | $7.9M | 1 |
| SUMMERVILLE FAMILY YOUNG MEN'S CHRISTIAN ASSOCIATION | Summerville | — | $7.9M | 2 |
| HOMES OF HOPE INC | Greenville | L25 Housing & Shelter | $7.8M | 1 |
| CHESTERFIELD COUNTY RURAL WATER | Chesterfield | — | $7.8M | 11 |
| PRISMA HEALTH MIDLANDS FOUNDATION | Columbia | E12 Health Care | $7.7M | 3 |
| Guardian Research Network Inc | Spartanburg | G30 Diseases, Disorders & Medical Disciplines | $7.7M | 5 |
| LOWCOUNTRY LEADERSHIP CHARTER SCHOOL | Hollywood | B29 Education | $7.7M | 1 |
| ONEWORLD HEALTH | Charleston | Q33 International, Foreign Affairs & National Security | $7.7M | 3 |
| Boys & Girls Clubs of the Midlands | Columbia | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $7.7M | 1 |
| ST JAMES HEALTH AND WELLNESS INC | McClellanville | — | $7.6M | 9 |
| HORRY COUNTY COMMISSION ON ALCOHOL | Conway | — | $7.5M | 1 |
| MANNING EDUCATIONAL ASSOCIATION | Manning | — | $7.5M | 1 |
| TRI-COUNTY COMMISSION ON ALCOHOL AND | Orangeburg | — | $7.5M | 1 |
| PORTER-GAUD FOUNDATION | Charleston | — | $7.5M | 1 |
| ABLE SOUTH CAROLINA INC | Columbia | T010 Philanthropy, Voluntarism & Grantmaking Foundations | $7.5M | 1 |
| HOSPICE AND PALLIATIVE CARE | Greenwood | — | $7.5M | 1 |
| PAWMETTO LIFELINE | Columbia | D200 Animal-Related | $7.5M | 1 |
| UPPER SAVANNAH COUNCIL OF | Greenwood | W20B Public & Societal Benefit | $7.4M | 2 |
| COLUMBIA METROPOLITAN CONVENTION | Columbia | — | $7.3M | 6 |
| SPARTANBURG PREPARATORY SCHOOL | Spartanburg | B29 Education | $7.3M | 1 |
