| AID Upstate Inc | Greenville | — | $10.9M | 6 |
| SOUTH CAROLINA DENTAL ASSOCIATION GROUP INSURANCE TRUST | Columbia | Y43 Mutual & Membership Benefit | $10.8M | 0 |
| COMMUNITY SERVICES FOR THE AGING INC | Spartanburg | — | $10.8M | 3 |
| COUNTRY CLUB OF CHARLESTON | Charleston | — | $10.7M | 8 |
| SENIOR CATERING | Little Mountain | K36Z Food, Agriculture & Nutrition | $10.7M | 0 |
| WESTEDGE FOUNDATION INC | Charleston | S20 Community Improvement & Capacity Building | $10.7M | 1 |
| Carolina Yacht Club | Charleston | — | $10.7M | 1 |
| MID CAROLINA CREDIT UNION | Lugoff | — | $10.7M | 4 |
| VANDY CHARITABLE FOUNDATION C/O ROBERT M BALDING | Georgetown | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $10.6M | 2 |
| CHARLESTON CHARTER SCHOOL FOR MATH AND SCIENCE | Charleston | B25 Education | $10.6M | 1 |
| Spartanburg Regional Healthcare System Foundation | Spartanburg | E22I Health Care | $10.5M | 5 |
| SENIOR SOLUTIONS | Anderson | P81Z Human Services | $10.4M | 1 |
| HILTON HEAD PREPARATORY SCHOOL | Hilton Head Island | B24Z Education | $10.4M | 3 |
| EAST POINT ACADEMY OF SOUTH CAROLINA | West Columbia | B29 Education | $10.4M | 1 |
| SOUTH CAROLINA FARM BUREAU FEDERATION | Columbia | — | $10.2M | 38 |
| VIRTUS ACADEMY OF SOUTH CAROLINA | Florence | W99 Public & Societal Benefit | $10.2M | 1 |
| ROYAL LIVE OAKS ACADEMY - RIDGELAND | Hardeevile | B29 Education | $10M | 1 |
| CLARENDON COUNTY DISABILITIES AND SPECIAL NEEDS BOARD | Manning | P820 Human Services | $9.9M | 1 |
| The Young Men's Christian Assoc of Columbia SC | Columbia | P270 Human Services | $9.9M | 3 |
| University of South Carolina Development Foundation | Columbia | B110 Education | $9.8M | 8 |
| RIVERWALK ACADEMY INC | Rock Hill | B28 Education | $9.7M | 1 |
| MEALS ON WHEELS OF GREENVILLE INC | Greenville | K36Z Food, Agriculture & Nutrition | $9.6M | 1 |
| SECESSION GOLF CLUB INC | Beaufort | N20 Recreation & Sports | $9.6M | 4 |
| THE SOUTH CAROLINA SOCIETY FOR THE PREVENTION OF CRUELTY TO ANIMALS | Greenville | D200 Animal-Related | $9.5M | 1 |
| SOUTH CAROLINA ASSOCIATION OF COMMUNITY ACTION PARTNERSHIPS | Columbia | — | $9.4M | 3 |
| THE VOLUNTEERS IN MEDICINE CLINIC | Hilton Head Island | — | $9.4M | 2 |
| FOX CREEK HIGH SCHOOL INC | North Augusta | B29 Education | $9.4M | 4 |
| SOUTH CAROLINA WATERFOWL ASSOCIATION | Pinewood | C320 Environment | $9.3M | 2 |
| South Carolina Manufacturing Extension Partnership | Greenville | S43L Community Improvement & Capacity Building | $9.3M | 8 |
| WILDS CHRISTIAN ASSOCIATION INC | Taylors | N20Z Recreation & Sports | $9.2M | 5 |
| WILSON HALL | Sumter | B24Z Education | $9.1M | 1 |
| DRS BRUCE & LEE FOUNDATION | Florence | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $9M | 11 |
| POLARIS TECH CHARTER SCHOOL | Ridgeland | B29 Education | $9M | 2 |
| KERSHAW COUNTY PUBLIC SCHOOLS FOUNDATION | Camden | B11 Education | $9M | 2 |
| Upward Unlimited | Spartanburg | O55 Youth Development | $8.9M | 7 |
| PIEDMONT COMMUNITY ACTIONS INC | Spartanburg | P20Z Human Services | $8.7M | 1 |
| LITTLE RIVER WATER AND SEWERAGE COMPANY INC | Conway | W80Z Public & Societal Benefit | $8.7M | 10 |
| CLEMSON ATHLETIC PROPERTIES COMPANY | Clemson | B12 Education | $8.7M | 8 |
| Mental Illness Recovery Center Inc | Columbia | — | $8.7M | 3 |
| Chester-Lancaster Disabilities & Special Needs Boa | Lancaster | P82Z Human Services | $8.6M | 1 |
| WE TAKE IT FOR CHARITY INC | Bluffton | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $8.6M | 1 |
| Marion-Dillon Disabilities and Special Need Board | Dillon | P820 Human Services | $8.6M | 1 |
| PICKENS COUNTY YMCA | Easley | — | $8.6M | 1 |
| DARNALL W AND SUSAN F BOYD FOUNDATION INC | Columbia | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $8.5M | 8 |
| ONEWORLD HEALTH | Charleston | Q33 International, Foreign Affairs & National Security | $8.4M | 2 |
| CHARLESTON COLLEGIATE SCHOOL | Johns Island | — | $8.4M | 4 |
| SOUTH CAROLINA STATE UNIVERSITY FOUNDATION INC | Orangeburg | — | $8.3M | 0 |
| THE SOUTH CAROLINA BAR FOUNDATION INC | Columbia | I128 Crime & Legal-Related | $8.3M | 1 |
| CARE-NET OF LANCASTER | Kershaw | — | $8.2M | 8 |
| AIKENBARNWELL CO CAA INC | Aiken | — | $8.2M | 1 |
