| APPLE TREE CHILDREN'S CENTER INC | Sioux Falls | P33 Human Services | $5.3M | 2 |
| YOUNG MEN'S CHRISTIAN ASSOCIATION | Sioux Falls | P27Z Human Services | $5.3M | 1 |
| CHARLES MIX ELECTRIC ASSOCIATION INC | Lake Andes | — | $5.3M | 9 |
| BLACK HILLS STATE UNIVERSITY | Spearfish | B110 Education | $5.2M | 2 |
| CENTRAL STATES FAIR | Rapid City | B82Z Education | $5.1M | 1 |
| GIRL SCOUTS - DAKOTA HORIZONS | Sioux Falls | O42 Youth Development | $5.1M | 2 |
| SEED FOR SUCCESS FOUNDATION | Sioux Falls | P12 Human Services | $5M | 1 |
| Pfeiffer Family Foundation | Aberdeen | P20 Human Services | $5M | 0 |
| WOUNDED KNEE SCHOOL DISTRICT | Manderson | B20Z Education | $5M | 9 |
| DAKOTA RESOURCES | Renner | X99 Religion-Related | $4.9M | 3 |
| COMMUNITY CONNECTIONS INC | Winner | P820 Human Services | $4.9M | 2 |
| LIFESCAPE | Sioux Falls | E12 Health Care | $4.9M | 7 |
| INDEPENDENT LIVING CHOICES | Sioux Falls | — | $4.9M | 1 |
| CENTER FOR FAMILY MEDICINE | Sioux Falls | B54Z Education | $4.9M | 8 |
| UNION COUNTY ELECTRIC COOPERATIVE INC | Elk Point | — | $4.8M | 8 |
| WALWORTH COUNTY CARE CENTER INC | Selby | E91 Health Care | $4.8M | 0 |
| Sun Dial Manor Inc | Bristol | — | $4.8M | 2 |
| EVAH C CRAY RESIDUARY CHARITABLE TRUST | Sioux Falls | — | $4.6M | 1 |
| BIG SIOUX COMMUNITY WATER | Egan | — | $4.6M | 11 |
| ARROWHEAD COUNTRY CLUB | Rapid City | N51Z Recreation & Sports | $4.6M | 1 |
| DAKOTA DUNES COUNTRY CLUB INC | Dakota Dunes | — | $4.5M | 0 |
| BLACK SPRING FOUNDATION INC | Sioux Falls | B99 Education | $4.5M | 0 |
| National Assn of Tower Erectors | Watertown | — | $4.5M | 3 |
| RAPID CITY CHRISTIAN EDUCATION ASSOC | Rapid City | B25P Education | $4.5M | 1 |
| BROOKINGS AREA TRANSIT AUTHORITY | Brookings | P520 Human Services | $4.5M | 1 |
| Sioux Rural Water System Inc | Watertown | — | $4.5M | 10 |
| LAKE AREA TECHNICAL COLLEGE FOUNDATION | Watertown | B82 Education | $4.5M | 0 |
| MILO STIP CHARITABLE REMAINDER | Sioux Falls | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.4M | 1 |
| Friends of South Dakota Public | Sioux Falls | A113 Arts, Culture & Humanities | $4.4M | 3 |
| THE GLORY HOUSE OF SIOUX FALLS | Sioux Falls | — | $4.4M | 1 |
| OAHE YOUNG MEN'S CHRISTIAN | Pierre | P270 Human Services | $4.4M | 2 |
| Homes are Possible Inc | Aberdeen | L80 Housing & Shelter | $4.4M | 1 |
| Great Plains Education Foundation Inc | Aberdeen | B112 Education | $4.3M | 0 |
| WEST RIVER TRANSIT AUTHORITY INC DBA | Spearfish | P52 Human Services | $4.3M | 1 |
| YANKTON THRIVE INC | Yankton | — | $4.2M | 2 |
| SOUTH DAKOTA FOUNDATION FOR MEDICAL CARE | Sioux Falls | E02 Health Care | $4.1M | 16 |
| GREATER SIOUX FALLS CHAMBER | Sioux Falls | — | $4.1M | 4 |
| RAPID CITY CLUB FOR BOYS INC | Rapid City | O210 Youth Development | $4.1M | 2 |
| WEST RIVER FOUNDATION | Sturgis | — | $4.1M | 6 |
| SOUTH DAKOTA SYMPHONY ORCHESTRA | Sioux Falls | A690 Arts, Culture & Humanities | $4.1M | 1 |
| COMMUNITY HEALTHCARE OF THE DAKOTAS | Sioux Falls | E32C Health Care | $4M | 1 |
| RESEARCH PARK AT SDSU | Brookings | B99 Education | $4M | 1 |
| PINE ROCK FOUNDATION INC | Sioux Falls | — | $3.9M | 4 |
| SENIOR CITIZEN SERVICES INC | Sioux Falls | P81Z Human Services | $3.9M | 2 |
| YOUTH & FAMILY SERVICES FOUNDATION | Rapid City | P11 Human Services | $3.8M | 1 |
| EXPERIENCE SIOUX FALLS | Sioux Falls | S41 Community Improvement & Capacity Building | $3.8M | 1 |
| THE VILLAGE OF HARMONY HILL INC | Watertown | L22 Housing & Shelter | $3.8M | 0 |
| KINGSBURY ELECTRIC COOPERATIVE INC | De Smet | — | $3.8M | 8 |
| WATERTOWN DEVELOPMENT COMPANY | Watertown | — | $3.7M | 1 |
| WELLSPRING INC | Rapid City | P460 Human Services | $3.7M | 3 |
