| COMMUNITY ENTRY SERVICES INC | Riverton | J330 Employment | $10M | 2 |
| THE JOHN P ELLBOGEN FOUNDATION | Laramie | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $9.8M | 10 |
| COWBOY JOE CLUB | Laramie | B43I Education | $8.8M | 0 |
| ARK REGIONAL SERVICES INC | Laramie | L210 Housing & Shelter | $8.8M | 1 |
| Cathedral Home for Children | Laramie | P700 Human Services | $8.6M | 3 |
| Central Wyoming Hospice & Transitions | Casper | — | $8.3M | 1 |
| JACKSON HOLE LAND TRUST | Jackson | C340 Environment | $7.9M | 3 |
| YOUTH EMERGENCY SERVICES INC | Gillette | P73Z Human Services | $7.8M | 1 |
| CLIMB | Cheyenne | P42 Human Services | $7.7M | 2 |
| WESTWARD HEIGHTS | Lander | E91Z Health Care | $7.6M | 1 |
| BLUE GRIT | Cheyenne | B30 Education | $7.4M | 3 |
| THE CHILDREN'S LEARNING CENTER INC | Jackson | — | $7.4M | 1 |
| THE PRIMROSE FOUNDATION | Wilson | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $7.3M | 0 |
| NATRONA COLLECTIVE HEALTH TRUST | Casper | E12 Health Care | $7.2M | 4 |
| CASPER COLLEGE FOUNDATION | Casper | B110 Education | $7.2M | 3 |
| Sheridan County Young Mens | Sheridan | P27Z Human Services | $6.7M | 1 |
| NATIONAL MUSEUM OF WILDLIFE ART | Jackson | A50 Arts, Culture & Humanities | $6.7M | 5 |
| Boys & Girls Club of Central Wyoming | Casper | O23Z Youth Development | $6.6M | 1 |
| MAGIC CITY ENTERPRISES INC | Cheyenne | J300 Employment | $6.3M | 1 |
| NORTHWEST COMMUNITY ACTION PROGRAMS | Worland | P20Z Human Services | $6.3M | 2 |
| Child Development Center of | Casper | — | $6.1M | 1 |
| SOBECKI FAMILY FOUNDATION | Jackson | I12 Crime & Legal-Related | $5.9M | 0 |
| Wyoming Chambers Health Benefit | Gillette | S41 Community Improvement & Capacity Building | $5.8M | 0 |
| STRIDE LEARNING CENTER | Cheyenne | B28Z Education | $5.7M | 2 |
| Rupert Spira Foundation | Jackson | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.6M | 0 |
| THE BRINTON MUSEUM ENDOWMENT FUND | Big Horn | A11 Arts, Culture & Humanities | $5.6M | 1 |
| CHILDREN'S RESOURCE CENTER | Powell | B28Z Education | $5.5M | 0 |
| LINCOLN UINTA CHILD DEVELOPMENT | Mountain View | B22Z Education | $5.5M | 1 |
| WYOMING HEALTH FAIRS | Casper | — | $5.4M | 1 |
| JACKSON HOLE HISTORICAL SOCIETY | Jackson | — | $5.4M | 1 |
| GARLAND LIGHT & POWER COMPANY | Powell | — | $5.3M | 10 |
| ABSAROKA HEAD START | Worland | — | $5.3M | 2 |
| SENIOR CITIZEN COUNCIL | Sheridan | P81Z Human Services | $5.3M | 1 |
| DEVELOPMENTAL PRESCHOOL AND | Laramie | P33 Human Services | $5.2M | 1 |
| NORTHWEST COLLEGE FOUNDATION | Powell | — | $5.2M | 1 |
| Wyoming Rescue Mission | Casper | L41Z Housing & Shelter | $5.1M | 1 |
| LARAMIE COUNTY COMMUNITY COLLEGE | Cheyenne | — | $5.1M | 4 |
| SUN PACIFIC FOUNDATION | Jackson | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.8M | 1 |
| LINCOLN SELF RELIANCE INC | Afton | P82 Human Services | $4.8M | 1 |
| CORBETT MEDICAL FOUNDATION | Saratoga | E80Z Health Care | $4.7M | 0 |
| Sweetwater County Child Development | Green River | — | $4.7M | 1 |
| BIG HORN ENTERPRISES INC | Thermopolis | P820 Human Services | $4.7M | 1 |
| CHEYENNE FRONTIER DAYS OLD WEST | Cheyenne | A540 Arts, Culture & Humanities | $4.6M | 2 |
| WILLIAM H AND CARRIE GOTTSCHE FOUNDATION | Thermopolis | T90Z Philanthropy, Voluntarism & Grantmaking Foundations | $4.6M | 1 |
| SHERIDAN COUNTY MEMORIAL HOSPITAL | Sheridan | E112 Health Care | $4.6M | 3 |
| ALTERNATIVE ELDER LIVING INC | Sheridan | — | $4.5M | 1 |
| THE BUTTONWOOD FAMILY FOUNDATION | Wilson | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.5M | 0 |
| One22 Inc | Jackson | P20 Human Services | $4.4M | 1 |
| Wyoming Credit Union Ins TR | Casper | Y43 Mutual & Membership Benefit | $4.4M | 0 |
| NATIONAL MUSEUM OF MILITARY VEHICLES | DuBois | A50 Arts, Culture & Humanities | $4.4M | 1 |
