| Institute of Contemporary Art Miami | Miami | A51 Arts, Culture & Humanities | $12.1M | 4 |
| Zephyrhills Health & Rehab Center Inc | Altamonte Springs | — | $12.1M | 11 |
| FLORIDA SURPLUS LINES SERVICE OFFICE | Tallahassee | — | $12M | 8 |
| SANIBEL-CAPTIVA CONSERVATION FOUNDATION | Sanibel | C300 Environment | $12M | 2 |
| BOYS AND GIRLS CLUBS OF STLUCIE | Ft Pierce | O21 Youth Development | $12M | 1 |
| Paulson Family Foundation | West Palm Beach | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $12M | 0 |
| ABILITIES INC OF FLORIDA | Clearwater | J300 Employment | $12M | 12 |
| NATIONAL FOUNDATION FOR ADVANCEMENT | Miami | A900 Arts, Culture & Humanities | $12M | 10 |
| Zephyr Haven Health & Rehab Center Inc | Altamonte Springs | — | $12M | 9 |
| AREA AGENCY ON AGING FOR NORTH FLORIDA | Tallahassee | — | $11.9M | 2 |
| OPA-LOCKA COMMUNITY DEVELOPMENT CORPORATION INC | Opa Locka | L20Z Housing & Shelter | $11.9M | 0 |
| BROWARD PERFORMING ARTS FOUNDATION | Fort Lauderdale | — | $11.9M | 3 |
| PINELLAS SUNCOAST ASSOCIATION | Clearwater | S41 Community Improvement & Capacity Building | $11.9M | 11 |
| MORTON PLANT MEASE HEALTH CARE | Clearwater | E11 Health Care | $11.9M | 4 |
| COASTAL HEALTH SYSTEMS OF BREVARD | Rockledge | — | $11.9M | 3 |
| TOP JEWISH FOUNDATION INC | Tampa | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $11.9M | 1 |
| CHERNA MOSKOWITZ FOUNDATION | Hallandale Beach | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $11.9M | 0 |
| THE GREENE SCHOOL INC | West Palm Beach | B24 Education | $11.9M | 0 |
| SANTA ROSA COUNTY SCHOOL READINESS | Milton | B012 Education | $11.9M | 1 |
| WAYUU TAYA FOUNDATIONINC | Riverview | Q33 International, Foreign Affairs & National Security | $11.9M | 2 |
| FLORIDA STATE COLLEGE AT JACKSONVILLE | Jacksonville | — | $11.9M | 2 |
| THE DS FOUNDATION | Miami | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $11.8M | 0 |
| PALM BEACH COUNTY FIREFIGHTERS | West Palm Beach | — | $11.8M | 1 |
| PELICAN'S NEST GOLF CLUB INC | Bonita Springs | N50 Recreation & Sports | $11.8M | 5 |
| HUMANE SOCIETY OF BROWARD COUNTY INC | Fort Lauderdale | D200 Animal-Related | $11.8M | 5 |
| MASADA HOME CARE INC | Miami | E92 Health Care | $11.8M | 4 |
| PHYSICAL MEDICINE SPECIALISTS INC | Jacksonville | E50 Health Care | $11.8M | 10 |
| LAUDERDALE YACHT CLUB INC | Fort Lauderdale | — | $11.8M | 7 |
| INNOVATION MONTESSORI OCOEE INC | Ocoee | B29 Education | $11.8M | 1 |
| NEW MISSION SYSTEMS INC | Ft Myers | Z99Z Unknown | $11.7M | 5 |
| ROUND LAKE CHARTER INC | Mount Dora | B29 Education | $11.7M | 1 |
| ADVOCATE PROGRAM INC | Miami | — | $11.7M | 4 |
| BERKOWITZ CONTEMPORARY FOUNDATION INC | South Miami | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $11.7M | 1 |
| AWS Foundation Incorporated | Miami | J22 Employment | $11.7M | 2 |
| THE SAILFISH CLUB OF FLORIDA INC | Palm Beach | — | $11.7M | 8 |
| Good Neighbors Inc | Clearwater | K30 Food, Agriculture & Nutrition | $11.7M | 0 |
| ADP TOTALSOURCE INC H&W TRUST | Miami | Y43 Mutual & Membership Benefit | $11.7M | 0 |
| HEALTH AND BEHAVIORAL DIMENSIONS INC | Hallandale | P82 Human Services | $11.7M | 4 |
| Stine Foundation Inc | Orlando | — | $11.7M | 1 |
| MUSEUM OF DISCOVERY AND SCIENCE INC | Fort Lauderdale | A570 Arts, Culture & Humanities | $11.7M | 6 |
| GANG ALTERNATIVE INC | Miami | O50 Youth Development | $11.7M | 3 |
| UNIVERSITY OF NORTH FLORIDA FINANCING | Jacksonville | B114 Education | $11.6M | 3 |
| FLORIDA PREGNANCY CARE NETWORK INC | Tallahassee | P30 Human Services | $11.6M | 1 |
| WJCT INC | Jacksonville | — | $11.6M | 4 |
| ALDERSGATE HEALTHCARE INC | Hialeah | E91 Health Care | $11.6M | 4 |
| CLASSICAL PREPARATORY INC | Spring Hill | B29 Education | $11.6M | 0 |
| FLORIDA COUNCIL AGAINST SEXUAL VIOLENCE | Tallahassee | F42Z Mental Health & Crisis Intervention | $11.6M | 2 |
| HANLEY CENTER FOUNDATION INC | West Palm Beach | F20 Mental Health & Crisis Intervention | $11.6M | 6 |
| Drug Abuse Treatment Association Inc | Jupiter | F200 Mental Health & Crisis Intervention | $11.5M | 4 |
| Sierra Foundation Inc | Sunny Isles Beach | T20J Philanthropy, Voluntarism & Grantmaking Foundations | $11.5M | 0 |
