| INTERNATIONAL ASSOCIATION OF MACHINISTS & AEROSPACE WORKERS | Bridgeton | — | $9.7M | 13 |
| GREENBRIAR HILLS COUNTRY CLUB | St Louis | — | $9.7M | 5 |
| SHEET METAL AIR RAIL AND TRANSPORTATION | St Louis | J40 Employment | $9.7M | 23 |
| STEWARD FAMILY FOUNDATION | St Louis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $9.6M | 0 |
| BEAUTIFUL SAVIOR HOME | Belton | E910 Health Care | $9.6M | 2 |
| Roofers Local 20 Health and Welfare Fund | Kansas City | — | $9.6M | 0 |
| OZARKS REGIONAL YMCA | Springfield | P270 Human Services | $9.6M | 3 |
| AMERICAN COLLEGE OF LIFESTYLE MEDICINE | Chesterfield | E70 Health Care | $9.6M | 7 |
| INDEPENDENCE HEALTH SYSTEM INC | Perryville | — | $9.6M | 2 |
| MOTHER OF GOOD COUNSEL HOME | St Louis | E91Z Health Care | $9.6M | 3 |
| Community Impact Network | Saint Louis | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $9.5M | 3 |
| Howard Electric Cooperative | Fayette | — | $9.5M | 17 |
| PEDAL THE CAUSE | St Louis | P20 Human Services | $9.5M | 4 |
| PGP Charitable Fund | Kansas City | P11 Human Services | $9.5M | 0 |
| WEST-CENTRAL INDEPENDENT LIVING SOLUTIONS | Warrensburg | P80 Human Services | $9.5M | 1 |
| RELIGION NEWS FOUNDATION | Columbia | X11 Religion-Related | $9.4M | 8 |
| ST LOUIS ECONOMIC DEVELOPMENT PARTNERSHIP | Saint Louis | — | $9.4M | 7 |
| GREATER ST LOUIS INC FOUNDATION | St Louis | S33I Community Improvement & Capacity Building | $9.4M | 2 |
| TEN TALENTS FOUNDATION | St Louis | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $9.4M | 2 |
| MEADOWBROOK COUNTRY CLUB | Ballwin | — | $9.4M | 5 |
| FAITH CHARITIES C/O ROBERT BLEVINS | Gladstone | E92 Health Care | $9.4M | 0 |
| ST LOUIS INTEGRATED HEALTH NETWORK | St Louis | H05 Medical Research | $9.3M | 2 |
| SCUOLA VITA NUOVA | Kansas City | B20 Education | $9.3M | 2 |
| RURAL ALLIANCE FOR BETTER FAMILY HEALTH | West Plains | E30 Health Care | $9.3M | 9 |
| PROJECT RESCUE FOUNDATION | Springfield | P50 Human Services | $9.3M | 5 |
| Ronald McDonald House Charities of Kansas City Inc | Kansas City | E860 Health Care | $9.2M | 3 |
| MENNONITE HOME ASSOCIATION INC | Hannibal | E91Z Health Care | $9.2M | 1 |
| BETTER FAMILY LIFE INC | Saint Louis | S20 Community Improvement & Capacity Building | $9.2M | 1 |
| MISSOURI NATIONAL EDUCATION ASSOCIATION | Jefferson City | — | $9.1M | 14 |
| Missourians Against the Deceptive Online Gambling Amendment | Saint Louis | — | $9.1M | 0 |
| MISSOURI CHILDREN'S TRUST FUND | Jefferson City | — | $9.1M | 0 |
| ASCENSION SOUTHEAST MICHIGAN COMMUNITY HEALTH | St Louis | E210 Health Care | $9.1M | 16 |
| NORTHLAND CHRISTIAN EDUCATION SYSTEM | Kansas City | B250 Education | $9.1M | 1 |
| KAIROS ACADEMIES | St Louis | B29 Education | $9M | 2 |
| BURNS & MCDONNELL FOUNDATION | Kansas City | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $9M | 0 |
| FORDLAND CLINIC INC | Fordland | E42Z Health Care | $9M | 8 |
| GREATER ST LOUIS BOY SCOUT TRUST FUND | St Louis | O110 Youth Development | $9M | 2 |
| Century Credit Union | St Louis | — | $9M | 3 |
| ENID AND CROSBY KEMPER FOUNDATION 10018904 | Kansas City | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $8.9M | 4 |
| Legal Services of Southern Missouri | Springfield | — | $8.9M | 7 |
| ASCENSION SETON FOUNDATION | St Louis | — | $8.9M | 3 |
| LIFE360 COMMUNITY SERVICES | Springfield | O20 Youth Development | $8.9M | 5 |
| PKD Foundation | Kansas City | — | $8.8M | 8 |
| RENEWABLE FUELS ASSOCIATION | Ellisville | — | $8.8M | 6 |
| MISSOURI SOYBEAN MERCHANDISING COUNCIL | Jefferson City | — | $8.8M | 0 |
| PARSONS BLEWETT MEMORIAL FUND | Saint Louis | B110 Education | $8.8M | 2 |
| DENNIS M JONES FAMILY FOUNDATION | St Louis | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $8.8M | 0 |
| Nodaway County Services for the Developmentally Disabled Inc | Maryville | P820 Human Services | $8.8M | 1 |
| CNS INTERNATIONAL MINISTRIES INC | Bethel | B99Z Education | $8.7M | 2 |
| PETER & PAUL COMMUNITY SERVICES INC | St Louis | L410 Housing & Shelter | $8.7M | 1 |
