| ST LOUIS COMMUNITY FOUNDATION | St Louis | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $10.3M | 9 |
| SHEET METAL AIR RAIL AND | St Louis | J40 Employment | $10.3M | 21 |
| WAYSIDE WAIFS INC | Kansas City | D200 Animal-Related | $10.3M | 6 |
| KANSAS CITY STREETCAR AUTHORITY | Kansas City | W40 Public & Societal Benefit | $10.2M | 3 |
| Employee Benefit Trust for Retirees of Spire | St Louis | — | $10.1M | 0 |
| International Union of Operating Engineers Local 101 | Kansas City | — | $10.1M | 20 |
| SRC BENEFITS PROGRAMS TRUST | Springfield | — | $10.1M | 0 |
| Haven of Our Lady of Peace Inc | St Louis | X200 Religion-Related | $10.1M | 6 |
| RURAL ALLIANCE FOR BETTER FAMILY HEALTH | West Plains | E30 Health Care | $10M | 9 |
| ST LOUIS SCOTT GALLAGHER FOUNDATION | Fenton | N64Z Recreation & Sports | $10M | 8 |
| BORGESS NURSING HOME INC | St Louis | — | $10M | 7 |
| PAINTERS DISTRICT COUNCIL #58 | St Louis | — | $9.9M | 20 |
| MANOR GROVE INC | St Louis | E910 Health Care | $9.9M | 6 |
| WHIMSADOODLE INC | Kansas City | A20 Arts, Culture & Humanities | $9.9M | 3 |
| MAKE-A-WISH FOUNDATION OF MISSOURI | Ballwin | P99Z Human Services | $9.9M | 4 |
| NATIONAL RURAL HEALTH ASSOCIATION | Kansas City | — | $9.9M | 8 |
| VIA CHRISTI VILLAGE HAYS INC | St Louis | — | $9.8M | 6 |
| HARRY S TRUMAN CHILDREN'S NEUROLOGICAL | Independence | P820 Human Services | $9.8M | 3 |
| METROPOLITAN LUTHERAN MINISTRY | Kansas City | — | $9.8M | 2 |
| KANSAS CITY PET PROJECT | Kansas City | D20 Animal-Related | $9.8M | 5 |
| CREATIVE CONCEPTS FOR LIVING INC | Hazelwood | P80 Human Services | $9.7M | 0 |
| MOTHER OF PERPETUAL HELP RESIDENCE INC | St Louis | — | $9.7M | 4 |
| INTERNATIONAL ASSOCIATION OF MACHINISTS & AEROSPACE WORKERS | Bridgeton | — | $9.7M | 13 |
| GREENBRIAR HILLS COUNTRY CLUB | St Louis | — | $9.7M | 5 |
| International Union Intl UAW Local 249 | Liberty | — | $9.7M | 25 |
| Heartland Foundation | St Joseph | E120 Health Care | $9.7M | 13 |
| MIDWEST SENIOR MINISTRIES | St Louis | P117 Human Services | $9.6M | 5 |
| COMMUNITY PARTNERSHIP OF THE OZARKS INC | Springfield | S20 Community Improvement & Capacity Building | $9.6M | 2 |
| Gibson Center for Behavioral Change | Cape Girardeau | F22Z Mental Health & Crisis Intervention | $9.6M | 1 |
| OZARKS REGIONAL YMCA | Springfield | P270 Human Services | $9.6M | 3 |
| AMERICAN COLLEGE OF LIFESTYLE | Chesterfield | E70 Health Care | $9.6M | 7 |
| INDEPENDENCE HEALTH SYSTEM INC | Perryville | — | $9.6M | 2 |
| PI BETA PHI FRATERNITY | Town Country | — | $9.6M | 11 |
| MOTHER OF GOOD COUNSEL HOME | St Louis | E91Z Health Care | $9.6M | 3 |
| HAGAN SCHOLARSHIP FOUNDATION | Columbia | B82 Education | $9.5M | 0 |
| SACRED HEART REHABILITATION INSTITUTE INC | St Louis | E50Z Health Care | $9.5M | 15 |
| Community Impact Network | Saint Louis | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $9.5M | 3 |
| BEAUTIFUL SAVIOR HOME | Belton | E910 Health Care | $9.5M | 6 |
| Howard Electric Cooperative | Fayette | — | $9.5M | 17 |
| RELIGION NEWS FOUNDATION | Columbia | X11 Religion-Related | $9.4M | 8 |
| MISSOURI SOYBEAN MERCHANDISING | Jefferson City | — | $9.4M | 0 |
| ST LOUIS ECONOMIC DEVELOPMENT | Saint Louis | — | $9.4M | 7 |
| GREATER ST LOUIS INC FOUNDATION | St Louis | S33I Community Improvement & Capacity Building | $9.4M | 2 |
| MEADOWBROOK COUNTRY CLUB | Ballwin | — | $9.4M | 5 |
| SOUTHWEST CENTER FOR INDEPENDENT | Springfield | — | $9.4M | 1 |
| FAITH CHARITIES | Gladstone | E92 Health Care | $9.4M | 0 |
| ST LOUIS INTEGRATED HEALTH NETWORK | St Louis | H05 Medical Research | $9.3M | 2 |
| VIA CHRISTI VILLAGE PITTSBURG INC | St Louis | — | $9.3M | 8 |
| DOUGLASS COMMUNITY SERVICES INC | Hannibal | P200 Human Services | $9.3M | 1 |
| Central Christian College of the Bible | Moberly | B42 Education | $9.3M | 3 |
