| RESTART INC | Kansas City | L410 Housing & Shelter | $8.4M | 3 |
| THE ESR PULITZER FOUNDATION | St Louis | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $8.4M | 0 |
| COXHEALTH FOUNDATION | Springfield | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $8.4M | 8 |
| NORTHWEST FOUNDATION INC | Maryville | B12 Education | $8.4M | 1 |
| SCHOOL SMART KC INC | Kansas City | B99 Education | $8.4M | 3 |
| KIDSMART INC | St Louis | B12 Education | $8.4M | 1 |
| BASS PRO SHOPS & CABELAS OUTDOOR FUND | Springfiled | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $8.3M | 0 |
| OZARK INDEPENDENT LIVING | West Plains | E50 Health Care | $8.3M | 0 |
| K-LIFE MINISTRIES | Branson | — | $8.3M | 0 |
| Joplin Historical Neighborhoods Inc | Joplin | M20 Public Safety, Disaster Preparedness & Relief | $8.3M | 0 |
| EMMANUEL FAMILY AND CHILD DEVELOPMENT CENTER & EMERGENCY SHELTER FOR CHILDR | Kansas City | B99 Education | $8.3M | 0 |
| MISSOURI CHAMBER OF COMMERCE & INDUSTRY | Jefferson City | — | $8.3M | 9 |
| SPRINGFIELD LITTLE THEATRE INC | Springfield | A65Z Arts, Culture & Humanities | $8.3M | 2 |
| DISTRICT III AREA AGENCY ON AGING | Warrensburg | P81Z Human Services | $8.2M | 3 |
| ASCENSION LIVING-LAKESHORE AT SIENA INC | St Louis | — | $8.2M | 6 |
| ALEXIAN BROTHERS MEDICAL GROUP SPECIALTY CARE | St Louis | E60 Health Care | $8.2M | 8 |
| BRANSONLAKES AREA CHAMBER OF | Branson | — | $8.2M | 7 |
| NATIONAL COUNCIL OF THE US SOCIETY OF | Maryland Heights | P99 Human Services | $8.2M | 5 |
| ASCENSION SETON FOUNDATION FKA SETON FUND OF THE DAUGHTERS OF CHARITY OF ST | St Louis | — | $8.2M | 3 |
| MISSOURI QUALITY CARE | Cameron | L200 Housing & Shelter | $8.1M | 0 |
| THE JSM CHARITABLE TRUST | St Louis | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $8.1M | 0 |
| St John Building Corporation | St Louis | S41 Community Improvement & Capacity Building | $8M | 6 |
| NORTH CENTRAL MISSOURI COLLEGE FOUNDATION | Trenton | — | $8M | 0 |
| GEORGE F MURPHY PERPETUAL CHARITABLE TRUST | Saint Louis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $8M | 1 |
| OPERATION FOOD SEARCH SUPPORT | St Louis | K30 Food, Agriculture & Nutrition | $8M | 1 |
| EMPLOYERS AND LABORERS LOCALS 100 & 397 | St Louis | — | $8M | 0 |
| WESTBOROUGH COUNTRY CLUB | St Louis | — | $8M | 5 |
| DEVELOPMENTAL SERVICES OF | St Clair | P82 Human Services | $8M | 0 |
| SHEET METAL WORKERS' LOCAL NO 2 | Kansas City | J40 Employment | $8M | 14 |
| Reproductive Health Services of | St Louis | E420 Health Care | $8M | 8 |
| CENTRAL MISSOURI COMMUNITY CREDIT UNION | Warrensburg | — | $8M | 4 |
| NOVA CENTER INC | Kansas City | P80Z Human Services | $7.9M | 1 |
| NEW COVENANT ACADEMY | Springfield | — | $7.9M | 3 |
| THE BELLWETHER FOUNDATION | St Louis | — | $7.8M | 0 |
| FIREFLY SCIENTISTS FOUNDATION | St Louis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $7.8M | 0 |
| Delta Center for Independent Living | Saint Peters | P80Z Human Services | $7.8M | 1 |
| THE JEREMIAH 924 FOUNDATION | Springfield | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $7.8M | 0 |
| MISSOURI WESTERN STATE UNIVERSITY | St Joseph | — | $7.8M | 2 |
| MAGDALA HOUSE | St Louis | F330 Mental Health & Crisis Intervention | $7.8M | 3 |
| ST LOUIS SCIENCE CENTER FOUNDATION | St Louis | U20 Science & Technology | $7.8M | 7 |
| Mid America Teen Challenge Training | Cape Girardeau | F22 Mental Health & Crisis Intervention | $7.8M | 1 |
| CITIZENS OF THE WORLD | Kansas City | B29 Education | $7.8M | 1 |
| International Brotherhood Electrical Workers IBEW LOCAL 53 | Kansas City | — | $7.8M | 21 |
| ASCENSION WISCONSIN FOUNDATION INC | St Louis | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $7.7M | 7 |
| THE OASIS INSTITUTE | St Ann | P810 Human Services | $7.7M | 6 |
| Centene Foundation | St Louis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $7.7M | 0 |
| THE DEBRUCE FOUNDATION | Kansas City | — | $7.7M | 0 |
| MID-AMERICA ARTS ALLIANCE | Kansas City | A260 Arts, Culture & Humanities | $7.7M | 4 |
| CONSERVATION EMPLOYEES' CREDIT UNION | Jefferson City | — | $7.7M | 1 |
| Provident Inc | St Louis | F300 Mental Health & Crisis Intervention | $7.6M | 7 |
