| ARIA COMMUNITY HEALTH CENTER | Lemoore | E30Z Health Care | $50M | 9 |
| CHRYSALIS CENTER | Los Angeles | — | $50M | 6 |
| MOMENTUM AGENCIES | Chatsworth | G23Z Diseases, Disorders & Medical Disciplines | $49.9M | 5 |
| MINERVA UNIVERSITY | San Francisco | B43 Education | $49.8M | 13 |
| DISABILITY RIGHTS CALIFORNIA | Sacramento | R230 Civil Rights, Social Action & Advocacy | $49.7M | 7 |
| UNITED INDIAN HEALTH SERVICES INC | Arcata | E320 Health Care | $49.5M | 25 |
| THE BUCKLEY SCHOOL | Sherman Oaks | — | $49.5M | 7 |
| HEALTH AND LIFE ORGANIZATION INC | Sacramento | E300 Health Care | $49.4M | 10 |
| McKinley Children's Center Inc | San Dimas | F33Z Mental Health & Crisis Intervention | $49.2M | 8 |
| Gracelight Community Health | Los Angeles | — | $49.1M | 9 |
| MENDOCINO COMMUNITY HEALTH CLINIC INC | Ukiah | E32Z Health Care | $49.1M | 11 |
| ST JOSEPH CENTER | Venice | P200 Human Services | $49.1M | 9 |
| VISTA DEL MAR CHILD AND FAMILY SERVICES | Los Angeles | P400 Human Services | $49M | 10 |
| FRED FINCH YOUTH CENTER | Oakland | F33Z Mental Health & Crisis Intervention | $48.9M | 8 |
| Mission Neighborhood Centers Inc | San Francisco | P280 Human Services | $48.7M | 10 |
| TACO BELL FOUNDATION INC | Irvine | Z99Z Unknown | $48.7M | 3 |
| GIVE2ASIA | Oakland | Q33 International, Foreign Affairs & National Security | $48.7M | 4 |
| AIRCONDITIONING AND REFRIGERATION | Orange | — | $48.6M | 1 |
| San Fernando Valley Community Mental | Van Nuys | — | $48.4M | 16 |
| The Claremont Colleges Inc | Claremont | B11 Education | $48.4M | 20 |
| MILKEN COMMUNITY SCHOOL | Los Angeles | — | $48.4M | 10 |
| SAN FRANCISCO TOURISM IMPROVEMENT | San Francisco | S41 Community Improvement & Capacity Building | $48.3M | 1 |
| SOUTHERN CALIFORNIA PAINTING AND DRYWALL | Covina | — | $48.3M | 0 |
| BAY AREA DELIVERY DRIVERS | Dublin | — | $48.2M | 0 |
| POLICYLINK | Oakland | S21 Community Improvement & Capacity Building | $48.2M | 15 |
| ENERGY ACTION FUND | San Francisco | C35 Environment | $48M | 3 |
| SOUTHWEST CARPENTERS TRAINING FUND | Los Angeles | — | $48M | 6 |
| HOPE SERVICES | San Jose | J300 Employment | $48M | 9 |
| NORTHERN CALIFORNIA RETIRED OFFICERS | Fairfield | P750 Human Services | $47.9M | 8 |
| Pacific Legal Foundation | Sacramento | I80Z Crime & Legal-Related | $47.9M | 14 |
| COMMUNITY ELDERCARE OF SAN DIEGO | San Diego | P75 Human Services | $47.7M | 9 |
| YOUNG MENS CHRISTIAN ASSOCIATION | Long Beach | P27Z Human Services | $47.7M | 11 |
| FOOD SHARE INC | Oxnard | K300 Food, Agriculture & Nutrition | $47.7M | 5 |
| GOODWILL CENTRAL COAST | Salinas | J32Z Employment | $47.4M | 7 |
| UNITED WAY INC | Los Angeles | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $47.4M | 10 |
| UNITED DOMESTIC WORKERS | San Diego | Y43 Mutual & Membership Benefit | $47.4M | 1 |
| SAN DOMENICO SCHOOL | San Anselmo | B20 Education | $47.3M | 8 |
| GARY AND MARY WEST SENIOR SERVICES INC | San Marcos | E24 Health Care | $47.3M | 8 |
| THE BROAD ART FOUNDATION | Los Angeles | A51Z Arts, Culture & Humanities | $47.3M | 1 |
| DESERT SANDS PUBLIC CHARTER INC | Valencia | B29 Education | $47.2M | 15 |
| HOMEBOY INDUSTRIES | Los Angeles | O53 Youth Development | $47.2M | 9 |
| THE HEAD ROYCE SCHOOL | Oakland | — | $47.2M | 13 |
| JOINT BENEFIT TRUST | Dublin | — | $47.2M | 0 |
| PARTNERSHIPS TO UPLIFT COMMUNITIES | Burbank | — | $47.1M | 5 |
| TANDEM PHILANTHROPIES | Menlo Park | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $47.1M | 0 |
| PANCREATIC CANCER ACTION NETWORK INC | El Segundo | G013 Diseases, Disorders & Medical Disciplines | $47.1M | 10 |
| CAMFED USA FOUNDATION | San Francisco | Q30 International, Foreign Affairs & National Security | $47.1M | 5 |
| Safe 1 Credit Union | Bakersfield | W61 Public & Societal Benefit | $47.1M | 20 |
| THE UNIVERSITY CORPORATION | Northridge | — | $47M | 13 |
| CALIFORNIA POLYTECHNIC STATE UNIVERSITY | San Luis Obispo | B11 Education | $47M | 6 |
