| PROSTATE CANCER FOUNDATION | Santa Monica | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $56.7M | 12 |
| SIERRA CANYON SCHOOL | Chatsworth | B20 Education | $56.7M | 11 |
| SEMPER FI & AMERICA'S FUND | Oceanside | E86 Health Care | $56.6M | 10 |
| CSU FULLERTON AUXILIARY SERVICES CORPORATION | Fullerton | B11 Education | $56.4M | 12 |
| TACO BELL FOUNDATION INC | Irvine | Z99Z Unknown | $56.3M | 6 |
| CATHOLIC CHARITIES OF SANTA CLARA COUNTY | San Jose | P20Z Human Services | $56.3M | 10 |
| Foundation for Grossmont and Cuyamaca Colleges | El Cajon | B125 Education | $56.3M | 8 |
| ROBERT LOUIS STEVENSON SCHOOL | Pebble Beach | B200 Education | $56.2M | 11 |
| CHOC FOUNDATION | Orange | E24 Health Care | $56.2M | 9 |
| POLYTECHNIC SCHOOL | Pasadena | B200 Education | $56.1M | 7 |
| CITIZENS OF THE WORLD CHARTER SCHOOLS LOS ANGELES | Los Angeles | B29 Education | $56.1M | 8 |
| PARA LOS NINOS | Los Angeles | P300 Human Services | $56M | 8 |
| INNER CITY EDUCATION FOUNDATION | Los Angeles | B25Z Education | $55.8M | 7 |
| GRANITE MOUNTAIN CHARTER SCHOOL | Lucerne Valley | B29 Education | $55.8M | 12 |
| STEP UP ON SECOND STREET INC | Santa Monica | P800 Human Services | $55.7M | 9 |
| MOMENTUM AGENCIES | Chatsworth | G23Z Diseases, Disorders & Medical Disciplines | $55.6M | 11 |
| ALBEDO INSURANCE COMPANY IC | Los Angeles | — | $55.6M | 10 |
| TIGER WOODS CHARITY EVENT CORP | Irvine | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $55.5M | 7 |
| The McConnell Foundation | Redding | B82 Education | $55.5M | 7 |
| SOUTHERN CALIFORNIA UNIVERSITY OF HEALTH SCIENCES | Whittier | B500 Education | $55.4M | 12 |
| MIDPEN HOUSING CORPORATION | Foster City | L210 Housing & Shelter | $55.4M | 8 |
| LONG BEACH STATE FOUNDATION | Long Beach | B11 Education | $55.4M | 5 |
| EL CAMINO REAL ALLIANCE | Woodland Hills | — | $55.3M | 13 |
| CRESCENT VIEW SOUTH INC | Valencia | B29 Education | $55.3M | 15 |
| SETI INSTITUTE | Mountain View | U310 Science & Technology | $55.2M | 9 |
| LINC HOUSING CORPORATION | Long Beach | L200 Housing & Shelter | $54.9M | 18 |
| THE HEAD ROYCE SCHOOL | Oakland | — | $54.9M | 11 |
| ALL FOR KIDS ORGANIZATION | Los Angeles | P300 Human Services | $54.9M | 8 |
| CANINE COMPANIONS FOR INDEPENDENCE INC | Santa Rosa | P8XZ Human Services | $54.9M | 15 |
| OAKWOOD SCHOOL | North Hollywood | B24Z Education | $54.9M | 8 |
| AMERICAN FIRST CREDIT UNION | Brea | — | $54.8M | 12 |
| LIGHTHOUSE FOR THE BLIND AND VISUALLY IMPAIRED | San Francisco | P860 Human Services | $54.8M | 13 |
| ROOM TO BREATHE PROJECT | San Francisco | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $54.8M | 0 |
| HISPANIC SCHOLARSHIP FUND | El Segundo | B820 Education | $54.5M | 8 |
| ALLIANCE FOR SAFETY AND JUSTICE | Oakland | I01 Crime & Legal-Related | $54.4M | 10 |
| WESTERN STATES PETROLEUM ASSOCIATION | Sacramento | — | $54.2M | 10 |
| POSSIBILITY LABS | San Francisco | P20 Human Services | $54M | 7 |
| LA JOLLA COUNTRY DAY SCHOOL | La Jolla | — | $54M | 7 |
| GOODWILL RETAIL SERVICES | Los Angeles | J11 Employment | $53.9M | 8 |
| TLCS INC | Sacramento | F34Z Mental Health & Crisis Intervention | $53.9M | 8 |
| HEALTH AND LIFE ORGANIZATION INC | Sacramento | E300 Health Care | $53.8M | 15 |
| SAN DIEGO TOURISM MARKETING DISTRICT | San Diego | S40 Community Improvement & Capacity Building | $53.8M | 1 |
| ELECTRICAL WORKERS HEALTH AND WELFARE TRUST FUND FOR SAN FRANCISCO | San Francisco | — | $53.8M | 0 |
| MEMORIALCARE SELECT HEALTH PLAN | Fountain Valley | E21 Health Care | $53.7M | 10 |
| PACIFIC CHARTER INSTITUTE INC | Sacramento | B29 Education | $53.7M | 16 |
| Academy of Television Arts and Sciences | North Hollywood | — | $53.6M | 7 |
| UNIVERSITY ENTERPRISES CORPORATION AT CSUSB | San Bernardino | B110 Education | $53.4M | 20 |
| SAN DIEGO BLOOD BANK | San Diego | — | $53.4M | 10 |
| OPERATING ENGINEERS VACATION-HOLIDAY SAVINGS TRUST | Pasadena | — | $53.3M | 6 |
| COMMUNITY SOLUTIONS FOR CHILDREN FAMILIES AND INDIVIDUALS | Gilroy | — | $53.3M | 10 |
