| COLLEGIATE ACADEMIES | New Orleans | B29 Education | $66.5M | 18 |
| Access Health Louisiana | Luling | E30 Health Care | $62.9M | 13 |
| ACADIA GENERAL HOSPITAL INC | Crowley | E20 Health Care | $62.6M | 7 |
| SOUTHEASTERN LOUISIANA AREA HEALTH | Hammond | — | $60.5M | 5 |
| CHILDRENS HOSPITAL ANESTHESIA | New Orleans | E60 Health Care | $59.7M | 8 |
| HIV-AIDS Alliance for Region Two Inc | Baton Rouge | G81 Diseases, Disorders & Medical Disciplines | $59.2M | 8 |
| FIRSTLINE SCHOOLS INC | New Orleans | B90 Education | $55.9M | 11 |
| ARKANSAS ELDER OUTREACH OF LITTLE ROCK | Baton Rouge | E91 Health Care | $55.6M | 7 |
| NEW ORLEANS AND COMPANY | New Orleans | — | $55.4M | 13 |
| LAFAYETTE HEALTH VENTURES INC | Lafayette | E21 Health Care | $55M | 11 |
| BATON ROUGE AREA FOUNDATION | Baton Rouge | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $54.6M | 11 |
| THE ALTA AND JOHN FRANKS FOUNDATION | Shreveport | — | $52.4M | 5 |
| MARILLAC COMMUNITY HEALTH CENTERS | New Orleans | E32 Health Care | $51.3M | 9 |
| CRESCENT CITY SCHOOLS | New Orleans | B03 Education | $49.9M | 5 |
| START Corporation | Houma | P80 Human Services | $49.6M | 14 |
| WINN COMMUNITY HEALTH CENTER INC | Winnfield | E320 Health Care | $49.1M | 11 |
| LIFESHARE BLOOD CENTER | Shreveport | — | $48M | 13 |
| DISCOVERY HEALTH SCIENCES FOUNDATION INC | Kenner | B29 Education | $47.4M | 3 |
| SUN BELT CONFERENCE | New Orleans | N41 Recreation & Sports | $47M | 5 |
| LOUISIANA ORGAN PROCUREMENT AGENCY | Covington | G44Z Diseases, Disorders & Medical Disciplines | $46.9M | 13 |
| FOUNDATION FOR LOUISIANA STUDENTS | Baton Rouge | B29 Education | $46.3M | 1 |
| LOUISIANA UNITED METHODIST CHILDREN & | Ruston | P200 Human Services | $45.9M | 4 |
| Audubon Nature Institute Inc | New Orleans | D120 Animal-Related | $44.9M | 9 |
| DILLARD UNIVERSITY | New Orleans | B420 Education | $44.8M | 0 |
| COMMUNITY SCHOOL FOR APPRENTICESHIP | Baton Rouge | B24Z Education | $44.4M | 1 |
| SAVOY MEDICAL MANAGMENT GROUP INC | Mamou | E22 Health Care | $44.4M | 5 |
| LAFAYETTE CHARTER FOUNDATION INC | Lafayette | B20 Education | $43.7M | 0 |
| IDEA PUBLIC SCHOOLS LOUISIANA INC | Baton Rouge | B24 Education | $43.5M | 0 |
| THE GREATER NEW ORLEANS FOUNDATION | New Orleans | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $43.2M | 11 |
| GOODWILL INDUSTRIES | New Orleans | J32Z Employment | $42.1M | 7 |
| NATIONAL NETWORK OF PUBLIC HEALTH | New Orleans | E70 Health Care | $42.1M | 8 |
| LAKE CHARLES CHARTER ACADEMY | Lake Charles | B29 Education | $41.4M | 0 |
| GOLDRING FAMILY FOUNDATION | Metairie | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $40.3M | 0 |
| RENEW - REINVENTING EDUCATION | New Orleans | B29 Education | $39.9M | 10 |
| PROVIDENT GROUP - BISON PROPERTIES INC | Baton Rouge | B11 Education | $39.9M | 4 |
| Desoto Hospital Association Inc | Mansfield | E220 Health Care | $39.8M | 9 |
| Georgia Protoncare Center Inc | Baton Rouge | E91 Health Care | $39.6M | 3 |
| ST MARTIN HOSPITAL INC | Breaux Bridge | E22 Health Care | $39M | 7 |
| ISIDORE NEWMAN SCHOOL | New Orleans | B200 Education | $38.6M | 11 |
| IBERIA COMPREHENSIVE COMMUNITY HEALTH CENTER | New Iberia | — | $38.1M | 10 |
| LAFOURCHE PARISH HOSPITAL SERVICE DIST 1 | Cut Off | — | $37.5M | 12 |
| Young Audiences Charter Association | Gretna | B29 Education | $36.9M | 2 |
| LCTCS FACILITIES CORPORATION | Metairie | B024 Education | $35.9M | 0 |
| ODYSSEY HOUSE LOUISIANA INC | New Orleans | F22 Mental Health & Crisis Intervention | $35.9M | 7 |
| NEW ORLEANS PHYSICIAN SERVICES INC | Marrero | S40 Community Improvement & Capacity Building | $35.7M | 8 |
| UNITY OF GREATER NEW ORLEANS INC | New Orleans | S50Z Community Improvement & Capacity Building | $35.5M | 1 |
| THE ST BERNARD PROJECT INC | New Orleans | M20 Public Safety, Disaster Preparedness & Relief | $35.3M | 7 |
| ST BERNARD HOSPITAL FOUNDATION INC | Chalmette | E21 Health Care | $35.2M | 5 |
| TOTAL COMMUNITY ACTION INC | New Orleans | P20Z Human Services | $35.1M | 8 |
| ST JAMES PLACE OF BATON ROUGE | Baton Rouge | P750 Human Services | $33.3M | 7 |
