| JEFFERSON COMMUNITY HEALTH | Marrero | E32 Health Care | $33.1M | 10 |
| Capitol City Family Health Center Inc | Baton Rouge | E32 Health Care | $32.8M | 9 |
| THE ARC OF ACADIANA INC | New Iberia | P82 Human Services | $32.5M | 5 |
| JEFFERSON DAVIS ELECTRIC COOPERATIVE | Jennings | — | $32.2M | 17 |
| Community Foundation of Acadiana | Lafayette | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $31.7M | 1 |
| LOUISIANA BAR FOUNDATION | New Orleans | I128 Crime & Legal-Related | $31.6M | 4 |
| LOUISIANA CHRISTIAN UNIVERSITY | Pineville | B420 Education | $31.1M | 5 |
| THE WILLIAM B WIENER JR FOUNDATION | Shreveport | — | $30.5M | 0 |
| GREATER BATON ROUGE FOOD BANK | Baton Rouge | — | $30.3M | 6 |
| KAPLAN GENERAL HOSPITAL | Kaplan | E22 Health Care | $30.3M | 8 |
| KEMPER AND LEILA WILLIAMS FOUNDATION IN | New Orleans | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $29.7M | 10 |
| ALGIERS CHARTER SCHOOL ASSOCIATION | New Orleans | B29 Education | $29.6M | 5 |
| THE EINSTEIN GROUP INC | New Orleans | B29 Education | $28.9M | 6 |
| POINTE COUPEE ELECTRIC MEMBERSHIP | New Roads | — | $28.9M | 12 |
| Centenary College of Louisiana | Shreveport | — | $28.7M | 6 |
| SPRINGHILL MEDICAL SERVICES INC | Springhill | E20 Health Care | $28.6M | 7 |
| NORTHEAST LA POWER COOPERATIVE INC | Winnsboro | — | $28.5M | 11 |
| CHRISTWOOD | Covington | P750 Human Services | $28.4M | 14 |
| BIOMEDICAL RESEARCH FOUNDATION OF | Shreveport | H920 Medical Research | $28.3M | 10 |
| HYNES CHARTER SCHOOL CORPORATION | New Orleans | B29 Education | $28.3M | 7 |
| ST THOMAS COMMUNITY HEALTH CENTER INC | New Orleans | E32 Health Care | $28.3M | 23 |
| TECHE ACTION BOARD INC | Franklin | E320 Health Care | $28.1M | 12 |
| THE BLOOD CENTER | New Orleans | E610 Health Care | $28M | 7 |
| FRANCISCAN MISSIONARIES OF OUR LADY | Baton Rouge | — | $28M | 14 |
| CONCORDIA ELECTRIC COOPERATIVE INC | Jonesville | — | $27.6M | 12 |
| CYBERSPACE INNOVATION CENTER INC | Bossier City | E12 Health Care | $27.2M | 0 |
| SUGAR BOWL | New Orleans | N700 Recreation & Sports | $27M | 7 |
| COMMUNITY ACADEMIES OF NEW ORLEANS INC | New Orleans | B24 Education | $26.8M | 4 |
| FRANCISCAN PACE INC | Baton Rouge | — | $26.3M | 12 |
| MAGNOLIA HEALTHCARE INC | Baton Rouge | — | $26.2M | 4 |
| NORTHWEST LOUISIANA FOOD BANK | Shreveport | K31 Food, Agriculture & Nutrition | $26.1M | 1 |
| LOUISIANA AMBULANCE ALLIANCE INC | Baton Rouge | S41 Community Improvement & Capacity Building | $25.6M | 1 |
| ADVOCATES FOR ART-BASED EDUCATION CORP | New Orleans | B29 Education | $25.5M | 8 |
| ESSENTIAL CREDIT UNION | Baton Rouge | — | $25.1M | 18 |
| CATHOLIC CHARITIES ARCHDIOCESE | New Orleans | P200 Human Services | $25M | 5 |
| THE HOSPICE FOUNDATION OF GREATER BATON | Baton Rouge | — | $25M | 1 |
| DONALD PALMER CHARITABLE FOUNDATION | Metairie | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $25M | 0 |
| ST ANTHONY'S GARDENS | New Orleans | — | $24M | 4 |
| SWLA CENTER FOR HEALTH SERVICES | Lake Charles | — | $23.9M | 9 |
| PRIMARY CARE PROVIDERS FOR A HEALTHY | Clinton | E70 Health Care | $23.9M | 9 |
| MORRIS JEFF COMMUNITY SCHOOL | New Orleans | B29 Education | $23.7M | 3 |
| STULLER FAMILY FOUNDATION | Lafayette | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $23.4M | 3 |
| ALLIANCE SAFETY COUNCIL | Baton Rouge | M40Z Public Safety, Disaster Preparedness & Relief | $23.3M | 13 |
| CADDO COMMUNITY ACTION AGENCY INC | Shreveport | P200 Human Services | $23.2M | 4 |
| UNIV OF LOUISIANA AT LAFAYETTE | Lafayette | B110 Education | $23M | 3 |
| METAIRIE PARK COUNTRY DAY SCHOOL | Metairie | B240 Education | $22.9M | 9 |
| Morehouse Community Medical Centers Inc | Bastrop | E32 Health Care | $22.8M | 12 |
| WORLD WAR II THEATRE INC | New Orleans | A11 Arts, Culture & Humanities | $22.4M | 3 |
| LOUISIANA TECH UNIVERSITY | Ruston | B110 Education | $22.3M | 0 |
| UNION GENERAL HOSPITAL | Farmerville | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $22.2M | 8 |
