| TEJANO CENTER FOR COMMUNITY CONCERNS INC | Houston | O50Z Youth Development | $47.5M | 7 |
| MEMBERS CHOICE CREDIT UNION | Houston | — | $47.4M | 16 |
| The Lanier Theological Library Foundation | Houston | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $47.4M | 1 |
| BUCKNER INTERNATIONAL | Dallas | P80 Human Services | $47.3M | 13 |
| Gainesville Community Hospital Inc | Gainesville | E20 Health Care | $47.3M | 13 |
| DALLAS COLLEGE FOUNDATION INC | Dallas | B41I Education | $47.3M | 2 |
| Houston Country Club | Houston | — | $47.2M | 12 |
| BARTLETT ELECTRIC COOPERATIVE INC | Bartlett | — | $47M | 21 |
| ISAS GROUP BENEFITS TRUST | Dallas | — | $47M | 26 |
| AMERICA CAN DBA TEXANS CAN | Dallas | B61Z Education | $47M | 7 |
| MHS Physicians of Texas | Houston | E32Z Health Care | $46.9M | 15 |
| JAMES N MCCOY FOUNDATION | Wichita Falls | T21J Philanthropy, Voluntarism & Grantmaking Foundations | $46.9M | 4 |
| READYONE INDUSTRIES INC | El Paso | J30Z Employment | $46.9M | 17 |
| THE LINBECK FAMILY CHARITABLE TRUST | Houston | S11 Community Improvement & Capacity Building | $46.8M | 2 |
| LLOYD'S REGISTER NORTH AMERICA INC | Houston | S410 Community Improvement & Capacity Building | $46.6M | 10 |
| Gateway Community Health Center Inc | Laredo | E32Z Health Care | $46.5M | 13 |
| Tri-County Behavioral Healthcare | Conroe | — | $46.5M | 11 |
| ST ANDREW'S EPISCOPAL SCHOOL INC | Austin | B240 Education | $46.5M | 6 |
| Houston Ballet Foundation | Houston | A630 Arts, Culture & Humanities | $46.4M | 10 |
| Central Missionary Clearinghouse Inc | Houston | — | $46.3M | 2 |
| Dallas Museum of Art | Dallas | A510 Arts, Culture & Humanities | $45.9M | 12 |
| ASSOCIATED CREDIT UNION OF TEXAS | League City | — | $45.9M | 6 |
| NORTH ALAMO WATER SUPPLY CORPORATION | Edinburg | — | $45.8M | 13 |
| YOUNG MEN'S CHRISTIAN ASSOCIATION OF AUSTIN | Austin | P27Z Human Services | $45.4M | 14 |
| BioBridge Global | San Antonio | E026 Health Care | $45.3M | 15 |
| THE MULVA FAMILY FOUNDATION | Austin | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $45.1M | 0 |
| ST JOSEPH PHYSICIAN ASSOCIATES | Bryan | E21 Health Care | $45M | 20 |
| Sid W Richardson Foundation | Fort Worth | Z99 Unknown | $44.6M | 4 |
| AMPP GLOBAL CENTER INC | Houston | — | $44.6M | 6 |
| Howard Payne University | Brownwood | B430 Education | $44.3M | 5 |
| THE HENDERSON-WESSENDORFF FOUNDATION | Richmond | — | $44.3M | 8 |
| ILA WEST GULF MARITIME ASSOCIATION CONTAINER ROYALTY TRUST FUND #1 | Houston | — | $44.2M | 0 |
| MOTIVATION EDUCATION AND TRAINING | New Caney | J220 Employment | $44M | 5 |
| M D ANDERSON SERVICES CORPORATION | Houston | E110 Health Care | $44M | 16 |
| FAITH FAMILY KIDS INC | DeSoto | B20 Education | $44M | 15 |
| OPERATION HOMEFRONT INC | San Antonio | S20 Community Improvement & Capacity Building | $43.9M | 5 |
| The EmeryWeiner Center for Jewish Education | Houston | B240 Education | $43.9M | 7 |
| DALLAS JEWISH COMMUNITY FOUNDATION | Dallas | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $43.8M | 4 |
| PERMIAN BASIN AREA FOUNDATION | Midland | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $43.7M | 5 |
| PAUL QUINN COLLEGE | Dallas | B420 Education | $43.5M | 5 |
| JAMES C & NORMA I SMITH FOUNDATION | Dallas | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $43.5M | 2 |
| CITY CREDIT UNION | Dallas | — | $43.4M | 10 |
| A CHARTER SCHOOLS INC | Dallas | B200 Education | $43.4M | 7 |
| People's Community Clinic Inc | Austin | E32Z Health Care | $43.2M | 10 |
| FIDELITY WELFARE BENEFIT PLANS VEBA TRUST | Westlake | Y20 Mutual & Membership Benefit | $42.7M | 0 |
| BRAZOS PRESBYTERIAN HOMES INC | Houston | P750 Human Services | $42.7M | 8 |
| Buffalo Bayou Partnership Inc | Houston | C110 Environment | $42.6M | 7 |
| CAMERON WORKS INC | Brownsville | J200 Employment | $42.4M | 0 |
| Investment and Research in Education Inc | Houston | X20 Religion-Related | $42.3M | 0 |
| Texas A&M University - Kingsville Foundation Inc | Kingsville | B43 Education | $42.3M | 0 |
