| FAYETTE ELECTRIC COOPERATIVE INC | La Grange | — | $39.2M | 13 |
| LIFENET INC | Texarkana | — | $39.1M | 5 |
| COALITION FOR THE HOMELESS OF | Houston | L00L Housing & Shelter | $39.1M | 6 |
| TEXAS CASA INC | Austin | R200 Civil Rights, Social Action & Advocacy | $39.1M | 7 |
| BRAZOS PRESBYTERIAN HOMES INC | Houston | P750 Human Services | $39.1M | 6 |
| COLUMBUS COMMUNITY HOSPITAL | Columbus | E220 Health Care | $39.1M | 8 |
| SPECIAL HEALTH RESOURCES FOR TEXAS INC | Longview | — | $39M | 7 |
| American College of Emergency Physicians | Dallas | — | $38.9M | 34 |
| HOUSTON BALLET FOUNDATION | Houston | A630 Arts, Culture & Humanities | $38.8M | 8 |
| Houston Symphony Society | Houston | A690 Arts, Culture & Humanities | $38.8M | 10 |
| PERMIAN BASIN COMMUNITY CENTERS FOR MHMR | Midland | F320 Mental Health & Crisis Intervention | $38.8M | 8 |
| Heavenly Fathers Foundation | Cisco | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $38.7M | 0 |
| YOUNG MEN'S CHRISTIAN ASSOCIATION OF GREATER SAN ANTONIO | San Antonio | — | $38.7M | 10 |
| BIG COUNTRY ELECTRIC COOPERATIVE INC | Roby | C35 Environment | $38.6M | 18 |
| CO TUA JOHN F CUNEO JR FND | Dallas | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $38.5M | 3 |
| Montgomery County Food Bank | Conroe | — | $38.5M | 2 |
| W W CARUTH JR FOUNDATION | Dallas | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $38.4M | 1 |
| SOUTHWEST TEXAS REGIONAL ADVISORY | San Antonio | E60 Health Care | $38.3M | 5 |
| One For Israel | Grapevine | Q11 International, Foreign Affairs & National Security | $38.2M | 6 |
| CENTRAL TEXAS WORKFORCE DEVELOPMENT | Belton | J20 Employment | $38.2M | 4 |
| TEJANO CENTER FOR COMMUNITY | Houston | O50Z Youth Development | $38.1M | 5 |
| UNIFIED HOUSING FOUNDATION INC | Farmers Branch | S50 Community Improvement & Capacity Building | $38M | 4 |
| PANOLA-HARRISON ELECTRIC | Marshall | — | $38M | 14 |
| Broadway Dallas Inc | Dallas | A610 Arts, Culture & Humanities | $38M | 10 |
| BAILEY COUNTY ELECTRIC COOPERATIVE | Muleshoe | — | $37.8M | 13 |
| LONGVIEW WELLNESS CENTER INC | Longview | E33Z Health Care | $37.8M | 10 |
| CENIKOR FOUNDATION | Houston | — | $37.8M | 9 |
| SOCIETY OF PETROLEUM ENGINEERS INC | Richardson | U030 Science & Technology | $37.7M | 14 |
| United Medical Centers | Eagle Pass | E320 Health Care | $37.5M | 9 |
| Scott & White Hospital-Taylor | Dallas | E220 Health Care | $37.3M | 21 |
| Education Credit Union | Amarillo | — | $37.2M | 9 |
| LAMAR COUNTY ELECTRIC COOPERATIVE ASSOCIATION | Blossom | — | $37.2M | 15 |
| John P McGovern Foundation | Houston | — | $37.1M | 3 |
| Dimmit Regional Hospital | Carrizo Springs | E220 Health Care | $37.1M | 15 |
| CHRISTUS NORTHEAST TEXAS HEALTH SYSTEM | Irving | X00Z Religion-Related | $37.1M | 20 |
| TEXAS ASSOCIATION OF REALTORS | Austin | — | $36.9M | 15 |
| MAYS FAMILY FOUNDATION | San Antonio | — | $36.9M | 1 |
| International Sustainable Energy Foundat | Austin | C99 Environment | $36.9M | 1 |
| The Robert A Welch Foundation | Houston | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $36.8M | 9 |
| MOTHERS AGAINST DRUNK DRIVING | Irving | I23Z Crime & Legal-Related | $36.8M | 10 |
| NEWMAN INTERNATIONAL ACADEMY | Arlington | X20 Religion-Related | $36.8M | 3 |
| Haven for Hope of Bexar County | San Antonio | L41 Housing & Shelter | $36.7M | 11 |
| PEROT MUSEUM OF NATURE & SCIENCE | Dallas | A560 Arts, Culture & Humanities | $36.6M | 11 |
| SHELL USA COMPANY FOUNDATION | Houston | — | $36.6M | 0 |
| CITY CREDIT UNION | Dallas | — | $36.5M | 10 |
| ST VINCENT DEPAUL REHABILITATION | Austin | J30Z Employment | $36.5M | 12 |
| Allied Pilots Association Welfare Benefits | Fort Worth | — | $36.5M | 1 |
| ST ANDREWS EPISCOPAL SCHOOL INC | Austin | B240 Education | $36.5M | 10 |
| HOUSTON AREA COMMUNITY SERVICES | Houston | G81 Diseases, Disorders & Medical Disciplines | $36.4M | 12 |
| ALLEGRO ORGANIZATIONAL SOLUTIONS INC | Houston | Q02 International, Foreign Affairs & National Security | $36.3M | 4 |
