| Nueces County MHMR Community Center | Corpus Christi | F30Z Mental Health & Crisis Intervention | $29.9M | 4 |
| EASTER SEALS OF GREATER HOUSTON INC | Houston | G23Z Diseases, Disorders & Medical Disciplines | $29.9M | 7 |
| JEROLD B KATZ FOUNDATION | Houston | — | $29.8M | 0 |
| Valley Baptist Legacy Foundation | Harlingen | E12 Health Care | $29.8M | 2 |
| Marketplace Ministries Inc | Plano | X20Z Religion-Related | $29.7M | 4 |
| GULF COAST COMMUNITY SERVICES ASSOCIATION | Houston | S200 Community Improvement & Capacity Building | $29.6M | 5 |
| Texas Children's Urgent Care | Bellaire | E21 Health Care | $29.6M | 17 |
| The Woodlands Christian Academy | The Woodlands | — | $29.6M | 7 |
| Meadows Foundation Inc | Dallas | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $29.6M | 21 |
| Mercury One Inc | Irving | Q33 International, Foreign Affairs & National Security | $29.6M | 4 |
| TRINITY SCHOOL OF MIDLAND TEXAS | Midland | B21Z Education | $29.5M | 4 |
| The Brookwood Community Inc | Brookshire | B280 Education | $29.5M | 7 |
| Lutheran Education Association of Houston | Friendswood | — | $29.4M | 4 |
| CoastLife Credit Union | Corpus Christi | — | $29.3M | 4 |
| UBONGO INTERNATIONAL | Austin | A30 Arts, Culture & Humanities | $29.2M | 1 |
| United Hands Relief Inc | Arlington | Q30 International, Foreign Affairs & National Security | $29.1M | 1 |
| THE SAFE ALLIANCE | Austin | — | $29.1M | 7 |
| Jewish Federation of Greater Houston | Houston | — | $29.1M | 7 |
| Community Healthcare of Texas | Fort Worth | P74 Human Services | $29.1M | 7 |
| ROBERT J & HELEN C KLEBERG FOUNDATION | San Antonio | — | $29M | 0 |
| DALLAS CENTER FOR THE PERFORMING ARTS FOUNDATION INC | Dallas | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $28.9M | 7 |
| The Rees-Jones Foundation | Dallas | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $28.9M | 3 |
| DALLAS SYMPHONY FOUNDATION | Dallas | A11 Arts, Culture & Humanities | $28.9M | 0 |
| Yoakum Community Hospital | Yoakum | — | $28.9M | 12 |
| THE KARAKIN FOUNDATION | Abilene | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $28.8M | 5 |
| Broughton Foundation Trust | Dallas | — | $28.8M | 4 |
| GREATER EAST TEXAS COMMUNITY ACTION PROGRAM | Nacogdoches | — | $28.8M | 2 |
| UNITED REGIONAL PHYSICIAN GROUP | Wichita Falls | E20 Health Care | $28.8M | 12 |
| JEWISH FAMILY SERVICE OF DALLAS INC DBA JEWISH FAMILY SERVICE | Dallas | P28Z Human Services | $28.7M | 5 |
| SOUTHWESTERN ADVENTIST UNIVERSITY | Keene | — | $28.7M | 4 |
| TEXAS PUBLIC POLICY FOUNDATION | Austin | W06Z Public & Societal Benefit | $28.7M | 15 |
| HANDS OF HEALING RESIDENTIAL T DBA HANDS OF HEALING | Baytown | P30 Human Services | $28.6M | 9 |
| HUSTON-TILLOTSON UNIVERSITY | Austin | — | $28.6M | 14 |
| NEIGHBORS IN NEED OF SERVICES INC | Rio Hondo | B210 Education | $28.6M | 1 |
| The University of Texas Law School Foundation | Austin | B11 Education | $28.6M | 1 |
| WHARTON COUNTY ELECTRIC COOPERATIVE INC | El Campo | — | $28.5M | 18 |
| THE ONESTAR NATIONAL SERVICE COMMISSION INC | Austin | S80 Community Improvement & Capacity Building | $28.3M | 5 |
| PRESBYTERIAN CHILDREN'S HOMES & SERVICES | Austin | P730 Human Services | $28.3M | 15 |
| Texas Health Resources Foundation | Arlington | E110 Health Care | $28.2M | 17 |
| THE 1687 FOUNDATION C/O DEBBIE GALLOWAY | McKinney | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $28.2M | 7 |
| COVENANT HOUSE TEXAS | Houston | P300 Human Services | $28.2M | 8 |
| LONGHORN VILLAGE | Austin | P75 Human Services | $28.2M | 8 |
| BETTERHEALTH A PLANNED PARENTHOOD PARTNERSHIP | Houston | E42 Health Care | $28.1M | 8 |
| ROLLING PLAINS MANAGEMENT CORPORATION | Crowell | P200 Human Services | $28M | 1 |
| MANVILLE WATER SUPPLY CORP | Coupland | — | $28M | 10 |
| SHARING LIFE COMMUNITY OUTREACH INC | Mesquite | P60 Human Services | $27.9M | 1 |
| SER Jobs Progress National Inc | Irving | — | $27.8M | 8 |
| Texas Agricultural Land Trust | San Antonio | C34 Environment | $27.8M | 2 |
| EDUCATIONAL LEADERSHIP INC | Houston | B20 Education | $27.7M | 6 |
| Southeast Texas Food Bank Inc | Beaumont | P20Z Human Services | $27.7M | 1 |
