| Tishomingo Health Services | Tupelo | E220 Health Care | $18.9M | 9 |
| JACKSON MEDICAL MALL FOUNDATION | Jackson | E120 Health Care | $18.8M | 3 |
| Marion Regional Medical Center Inc | Tupelo | E22 Health Care | $18.7M | 10 |
| SOUTH DELTA PLANNING & | Greenville | — | $18.6M | 29 |
| PHIL HARDIN FOUNDATION | Meridian | — | $18.3M | 7 |
| JACKSON STATE UNIVERSITY | Jackson | B42Z Education | $17.9M | 0 |
| MAGEE BENEVOLENT ASSOCIATION | Magee | E220 Health Care | $17.7M | 9 |
| ST LUKE FOUNDATION | McComb | E11 Health Care | $17.3M | 5 |
| MISSISSIPPI METHODIST SENIOR SERVICES | Tupelo | P81Z Human Services | $16.9M | 11 |
| UNITED METHODIST SENIOR SERVICES | Tupelo | E910 Health Care | $16.9M | 8 |
| W G YATES & SONS CONSTRUCTION CO | Philadelphia | — | $16.7M | 0 |
| HINDS COMMUNITY COLLEGE FOUNDATION | Raymond | — | $16.6M | 0 |
| ACCESS FAMILY HEALTH SERVICES INC | Smithville | E320 Health Care | $16M | 9 |
| COMMUNITY FOUNDATION FOR MISSISSIPPI | Jackson | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $15.8M | 2 |
| WILKINSON COUNTY INDUSTRIAL DEVELOPMENT | Woodville | I30Z Crime & Legal-Related | $15.8M | 5 |
| American Contract Bridge League Inc | Horn Lake | — | $15.8M | 26 |
| HINDS COUNTY HUMAN RESOURCE AGENCY | Jackson | P200 Human Services | $15.7M | 4 |
| Aaron E Henry Community Health Services Center Inc | Clarksdale | E300 Health Care | $15.6M | 15 |
| BEAR CREEK WATER ASSOCIATION INC | Madison | — | $15.5M | 9 |
| TISHOMINGO COUNTY ELEC POWER ASSN | Iuka | — | $15.5M | 17 |
| PHI THETA KAPPA | Jackson | — | $15.3M | 7 |
| FRENCH CAMP ACADEMY | French Camp | B26Z Education | $14.8M | 3 |
| MISSISSIPPI STATE UNIVERSITY EDUCATIONAL | Missisippi State | E110 Health Care | $14.4M | 0 |
| PONTOTOC ELECTRIC POWER ASSOCIATION | Pontotoc | — | $14.3M | 15 |
| SCOTT REGIONAL MEDICAL CENTER INC | Meridian | E20 Health Care | $14.2M | 9 |
| HARTFIELD ACADEMY INC | Flowood | — | $14.2M | 1 |
| RUST COLLEGE | Holly Springs | B420 Education | $14.1M | 9 |
| MISSISSIPPI FARM BUREAU FEDERATION | Jackson | — | $14.1M | 17 |
| COMMUNITY DEVELOPMENT INCORPORATED | Richton | B21 Education | $13.9M | 4 |
| JACKSON PREPARATORY SCHOOL FOUNDATION | Flowood | — | $13.9M | 4 |
| COMMUNITY ACTION OF | Moss Point | P200 Human Services | $13.8M | 1 |
| CENTURY CLUB CHARITIES INC | Ridgeland | N6AJ Recreation & Sports | $13.6M | 1 |
| WASHINGTON COUNTY OPPORTUNITIES INC | Greenville | — | $13.4M | 1 |
| THE BADDOUR CENTER INC | Senatobia | P730 Human Services | $13.3M | 1 |
| THE LUCKYDAY FOUNDATION | Jackson | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.2M | 6 |
| Family Health Center Inc | Laurel | E320 Health Care | $12.9M | 10 |
| TIPPAH ELECTRIC POWER ASSOCIATION | Ripley | — | $12.4M | 11 |
| WILDLIFE MISSISSIPPI | Stoneville | D300 Animal-Related | $12.4M | 1 |
| NORTH MISSISSIPPI EDUCATION | University | B90 Education | $12.2M | 3 |
| EAST CENTRAL MISSISSIPPI HEALTHCARE INC | Sebastopol | E39Z Health Care | $11.6M | 8 |
| BLUE CROSS & BLUE SHIELD OF | Flowood | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $11.5M | 2 |
| PRESBYTERIAN CHRISTIAN SCHOOL | Hattiesburg | B24Z Education | $11.5M | 1 |
| THE CHISHOLM FOUNDATION | Laurel | — | $11.2M | 0 |
| MARTY STUART CENTER FOR COUNTRY | Philadelphia | A68 Arts, Culture & Humanities | $11.1M | 0 |
| GOLDEN AGE INC | Greenwood | — | $10.7M | 4 |
| GOODWILL INDUSTRIES OF SOUTH MISSISSIPPI | Gulfport | J320 Employment | $10.5M | 2 |
| STATE CHARTERED CREDIT UNIONS IN MS | Jackson | — | $10.4M | 5 |
| GOODWILL INDUSTRIES OF MISSISSIPPI INC | Ridgeland | — | $10.2M | 1 |
| COMMUNITY FOUNDATION OF NORTHWEST | Hernando | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $10.1M | 2 |
| SOUTHWEST MISSISSIPPI PLANNING AND | Natchez | S200 Community Improvement & Capacity Building | $10.1M | 0 |
