| FOOTHILLS COMMUNITY HEALTH CARE INC | Anderson | E30 Health Care | $11.8M | 9 |
| DATAW ISLAND CLUB INC | Beaufort | N50 Recreation & Sports | $11.8M | 4 |
| SOUTH CAROLINA BANKERS | Chapin | — | $11.7M | 1 |
| PALMETTO DUNES PROPERTY OWNERS | Hilton Head Island | P20 Human Services | $11.7M | 5 |
| SOUTH CAROLINA BAR | Columbia | — | $11.7M | 6 |
| FOOTHILLS COMMUNITY FOUNDATION | Anderson | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $11.6M | 1 |
| THE STATE AGRICULTURAL & MECHANICAL | Columbia | N520 Recreation & Sports | $11.6M | 11 |
| CAMDEN MILITARY ACADEMY | Camden | B25Z Education | $11.6M | 1 |
| GUTHRIE RISK RETENTION GROUP | Charleston | F11 Mental Health & Crisis Intervention | $11.5M | 2 |
| SPRING ISLAND CLUB | Okatie | N6A Recreation & Sports | $11.4M | 12 |
| THORNBLADE CLUB INC | Greer | — | $11.4M | 5 |
| OLDFIELD CLUB | Okatie | N50 Recreation & Sports | $11.4M | 0 |
| BEAUFORT-JASPER EOC INC | Beaufort | — | $11.4M | 2 |
| Horry County Disabilities & Special | Conway | P820 Human Services | $11.4M | 2 |
| AMERICAN LEPROSY MISSIONS INC | Greenville | Q123 International, Foreign Affairs & National Security | $11.3M | 7 |
| UNITED HOUSING CONNECTIONS | Greenville | S20 Community Improvement & Capacity Building | $11.3M | 0 |
| Oconee Medical Holdings | Seneca | E220 Health Care | $11.2M | 0 |
| SPOLETO FESTIVAL USA INC | Charleston | A200 Arts, Culture & Humanities | $11.2M | 7 |
| INTERNATIONAL AFRICAN AMERICAN MUSEUM | Charleston | A50 Arts, Culture & Humanities | $11.2M | 7 |
| SEABROOK ISLAND PROPERTY OWNERS | Johns Island | S22 Community Improvement & Capacity Building | $11.1M | 4 |
| PINEWOOD PREPARATORY SCHOOL | Summerville | B24Z Education | $11.1M | 1 |
| LOWCOUNTRY AIDS SERVICES | Charleston | — | $11M | 1 |
| AID Upstate Inc | Greenville | — | $10.9M | 6 |
| ROYAL LIVE OAKS ACADEMY - RIDGELAND | Hardeevile | B29 Education | $10.9M | 1 |
| SOUTH CAROLINA DENTAL ASSOCIATION GROUP | Columbia | Y43 Mutual & Membership Benefit | $10.8M | 0 |
| COMMUNITY SERVICES FOR THE AGING INC | Spartanburg | — | $10.8M | 3 |
| OCAB Community Action Agency Inc | Orangeburg | S200 Community Improvement & Capacity Building | $10.8M | 1 |
| RIVERVIEW CHARTER SCHOOL | Beaufort | B24 Education | $10.8M | 1 |
| COUNTRY CLUB OF CHARLESTON | Charleston | — | $10.7M | 8 |
| SENIOR CATERING | Little Mountain | K36Z Food, Agriculture & Nutrition | $10.7M | 0 |
| WESTEDGE FOUNDATION INC | Charleston | S20 Community Improvement & Capacity Building | $10.7M | 1 |
| Carolina Yacht Club | Charleston | — | $10.7M | 1 |
| SECESSION GOLF CLUB INC | Beaufort | N20 Recreation & Sports | $10.7M | 4 |
| VANDY CHARITABLE FOUNDATION | Georgetown | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $10.6M | 2 |
| CHARLESTON COUNTY HUMAN SERVICES COMMISSION INC | Charleston | P200 Human Services | $10.6M | 2 |
| HOLLINGSWORTH FUNDS INC | Greenville | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $10.5M | 15 |
| Spartanburg Regional Healthcare System Foundation | Spartanburg | E22I Health Care | $10.5M | 5 |
| SENIOR SOLUTIONS | Anderson | P81Z Human Services | $10.4M | 1 |
| HILTON HEAD PREPARATORY SCHOOL | Hilton Head Island | B24Z Education | $10.4M | 3 |
| EAST POINT ACADEMY OF SOUTH CAROLINA | West Columbia | B29 Education | $10.4M | 1 |
| SOUTH CAROLINA FARM BUREAU FEDERATION | Columbia | — | $10.2M | 38 |
| CHARLESTON GAILLARD MANAGEMENT | Charleston | A02 Arts, Culture & Humanities | $10M | 3 |
| CHARLESTON CHARTER SCHOOL FOR MATH AND | Charleston | B25 Education | $9.9M | 1 |
| South Carolina Manufacturing | Greenville | S43L Community Improvement & Capacity Building | $9.9M | 8 |
| The Young Men's Christian Assoc of Columbia SC | Columbia | P270 Human Services | $9.9M | 3 |
| MEALS ON WHEELS OF GREENVILLE INC | Greenville | K36Z Food, Agriculture & Nutrition | $9.6M | 1 |
| MID CAROLINA CREDIT UNION | Lugoff | — | $9.6M | 4 |
| THE SOUTH CAROLINA SOCIETY FOR THE | Greenville | D200 Animal-Related | $9.5M | 1 |
| SPARTANBURG ACADEMIC MOVEMENT | Spartanburg | B90 Education | $9.5M | 1 |
| CLINTON COLLEGE | Rock Hill | B41Z Education | $9.4M | 5 |
