| MCLEOD HEALTH FOUNDATION | Florence | E22I Health Care | $16.7M | 2 |
| BUILDING EQUITY SOONER FOR TOMORROW | Greenville | B11 Education | $16.5M | 2 |
| SOUTH CAROLINA RESEARCH AUTHORITY | Columbia | U40 Science & Technology | $16.2M | 10 |
| St Josephs Catholic School Inc | Greenville | — | $16.2M | 4 |
| SHERMAN COLLEGE OF STRAIGHT CHIROPRACTIC | Spartanburg | B500 Education | $16.1M | 10 |
| BROOKGREEN GARDENS | Pawleys Island | C410 Environment | $16M | 2 |
| SPC CREDIT UNION | Hartsville | — | $15.8M | 5 |
| Municipal Association of South Carolina | Columbia | — | $15.6M | 12 |
| HORSE CREEK ACADEMY | Aiken | B29 Education | $15.4M | 2 |
| NATIONAL WILD TURKEY FEDERATION INC | Edgefield | C300 Environment | $15.3M | 0 |
| BRIDGES PREPARATORY SCHOOL | Beaufort | B29 Education | $15.2M | 1 |
| SOUTH CAROLINA AUTOMOBILE DEALERS | Columbia | — | $15.1M | 0 |
| GEORGETOWN KRAFT CREDIT UNION | Georgetown | — | $15M | 3 |
| United Methodist Manor of the Pee Dee | Florence | P110 Human Services | $15M | 3 |
| UNIVERSITY OF SOUTH CAROLINA | Columbia | — | $15M | 4 |
| PEE DEE MEDICAL AND HEALTH SCIENCES | Florence | B99 Education | $14.6M | 1 |
| AIKEN HORSE PARK FOUNDATION | Aiken | D99 Animal-Related | $14.5M | 1 |
| MUSC HEALTH PARTNERS | Charleston | E11 Health Care | $14.5M | 7 |
| TMPC Nonprofit Holdings Inc | Columbia | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $14.4M | 0 |
| Medical Services of America Inc Employee Health Benefit Plan Trust | Lexington | — | $14.2M | 0 |
| HOSPICE OF THE UPSTATE INC | Anderson | — | $14.1M | 1 |
| South Carolina Legal Services | Greenville | I80Z Crime & Legal-Related | $14.1M | 7 |
| CHARLESTON ANIMAL SOCIETY | North Charleston | D200 Animal-Related | $14.1M | 6 |
| THORNWELL | Clinton | P730 Human Services | $14.1M | 5 |
| ETV Endowment of South Carolina Inc | Spartanburg | A120 Arts, Culture & Humanities | $14M | 2 |
| ONE-EIGHTY PLACE | Charleston | L410 Housing & Shelter | $14M | 6 |
| FOREST LAKE CLUB | Columbia | N50 Recreation & Sports | $13.8M | 1 |
| COMMUNITY FOUNDATION OF THE LOWCOUNTRY | Hilton Head Island | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $13.8M | 2 |
| CAROLINA COMMUNITY ACTIONS INC | Rock Hill | P20Z Human Services | $13.7M | 3 |
| SPARTANBURG DAY SCHOOL | Spartanburg | — | $13.7M | 2 |
| ELECTRIC COOPERATIVES | Cayce | — | $13.7M | 6 |
| COMMUNITY MEDICINE FOUNDATION INC | Rock Hill | — | $13.6M | 12 |
| Westminster Presbyterian Center Inc | Rock Hill | E91 Health Care | $13.5M | 6 |
| BERKELEY CITIZENS INC | Moncks Corner | P82Z Human Services | $13.5M | 1 |
| GREATER LAKE CITY ALLIANCE | Lake City | S20 Community Improvement & Capacity Building | $13.3M | 1 |
| SEA PINES COUNTRY CLUB INC | Hilton Head Island | — | $13.3M | 8 |
| COLLEGE OF CHARLESTON FOUNDATION | Charleston | B114 Education | $13.2M | 5 |
| Roper St Francis Foundation | Charleston | E80 Health Care | $13.2M | 10 |
| ONE NATION INNOVATION | Columbia | U05 Science & Technology | $13M | 3 |
| YOUNG MENS CHRISTIAN ASSOCIATION of Greater Spartanburg | Spartanburg | — | $12.9M | 1 |
| ALSTON WILKES SOCIETY | Columbia | — | $12.9M | 1 |
| NATIONAL HONORARY BETA CLUB | Spartanburg | O50Z Youth Development | $12.9M | 20 |
| LEXINGTON RICHLAND ALCOHOL & | Columbia | F22Z Mental Health & Crisis Intervention | $12.8M | 2 |
| SEABROOK OF HILTON HEAD | Hilton Head Island | — | $12.8M | 1 |
| HILTON HEAD CHRISTIAN ACADEMY | Bluffton | B24Z Education | $12.6M | 0 |
| HILTON HEAD ISLAND - BLUFFTON | Hilton Head Island | — | $12.5M | 5 |
| SOUTHERN CAROLINA REGIONAL DEVELOPMENT | Barnwell | S41Z Community Improvement & Capacity Building | $12.4M | 3 |
| UNITED WAY OF GREENVILLE COUNTY INC | Greenville | — | $12.2M | 6 |
| VISITGREENVILLESC | Greenville | — | $12.1M | 4 |
| GRAY COLLEGIATE ACADEMY INC | West Columbia | B29 Education | $11.8M | 2 |
