| CATHOLIC CHARITIES OF LOS ANGELES INC | Los Angeles | P200 Human Services | $69.3M | 7 |
| Los Angeles Tourism & Convention Board | Los Angeles | — | $69.2M | 10 |
| TENDERLOIN HOUSING CLINIC INC | San Francisco | L52Z Housing & Shelter | $69M | 8 |
| Metropolitan Area Advisory Committee on Anti-Poverty of San Diego County In | Chula Vista | P40 Human Services | $68.6M | 12 |
| CALIFORNIA STATE UNIVERSITY LONG BEACH RESEARCH FOUNDATION | Long Beach | B110 Education | $68.5M | 14 |
| GRANCELL VILLAGE OF THE LOS ANGELES JEWISH HOME FOR THE AGING | Reseda | P750 Human Services | $68.5M | 7 |
| WYATT FAMILY FOUNDATION | Santa Barbara | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $68.3M | 3 |
| AMERICAN ACADEMY OF OPHTHALMOLOGY INC | San Francisco | — | $68.3M | 28 |
| ST VINCENT DE PAUL VILLAGE INC | San Diego | X20Z Religion-Related | $68.1M | 10 |
| THE ALBERTSONS COMPANIES FOUNDATION | Pleasanton | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $68.1M | 0 |
| SAN FRANCISCO SYMPHONY | San Francisco | A690 Arts, Culture & Humanities | $67.8M | 7 |
| SAINT AGNES MEDICAL FOUNDATION | Fresno | E110 Health Care | $67.8M | 9 |
| EPISCOPAL COMMUNITY SERVICES OF SAN FRANCISCO | San Francisco | P85Z Human Services | $67.7M | 9 |
| SOUTHWESTERN LAW SCHOOL | Los Angeles | B110 Education | $67.6M | 11 |
| IAPMO RESEARCH AND TESTING INC | Ontario | — | $67.4M | 8 |
| INTERNATIONAL BROTHERHOOD OF ELECTRICAL WORKERS LOCAL 1245 | Vacaville | — | $67.2M | 20 |
| CABRILLO POINT ACADEMY | Poway | B29 Education | $67.2M | 18 |
| Adventist Health Tulare | Tulare | — | $67.2M | 26 |
| HATHAWAY-SYCAMORES CHILD AND FAMILY SERVICES | Los Angeles | P30 Human Services | $67M | 11 |
| JEWISH FAMILY AND CHILDREN'S SERVICES | San Francisco | P400 Human Services | $67M | 9 |
| PARKER INSTITUTE FOR CANCER IMMUNOTHERAPY | San Francisco | E12 Health Care | $66.9M | 8 |
| UNIVERSITY CREDIT UNION | Los Angeles | — | $66.9M | 18 |
| KEDREN COMMUNITY HEALTH CENTERINC | Los Angeles | F320 Mental Health & Crisis Intervention | $66.9M | 12 |
| ASSOCIATED STUDENTS UCLA | Los Angeles | B110 Education | $66.8M | 14 |
| EPISCOPAL COMMUNITIES & SERVICES FOR SENIORS | Altadena | L21 Housing & Shelter | $66.8M | 13 |
| Felton Institute | Alameda | — | $66.8M | 9 |
| VENTURA COUNTY CREDIT UNION | Ventura | — | $66.7M | 24 |
| THE EXPLORATORIUM | San Francisco | A500 Arts, Culture & Humanities | $66.6M | 10 |
| PERFORMING ARTS CENTER OF LOS ANGELES COUNTY | Los Angeles | A610 Arts, Culture & Humanities | $66.6M | 11 |
| BURNING MAN PROJECT | San Francisco | S20 Community Improvement & Capacity Building | $66.6M | 17 |
| ROOM TO READ | San Francisco | B90 Education | $66.5M | 9 |
| EDWARD CHARLES FOUNDATION | Beverly Hills | P99 Human Services | $66.5M | 0 |
| EAH Inc | San Rafael | L210 Housing & Shelter | $66.2M | 9 |
| St Margaret of Scotland Episcopal School | San Juan Capistrano | — | $66M | 13 |
| The Wildlands Conservancy | Oak Glen | C340 Environment | $66M | 4 |
| CLAREMONT INVESTMENT FUND | Claremont | B19 Education | $66M | 5 |
| BIRMINGHAM COMMUNITY CHARTER HIGH SCHOOL | Van Nuys | B29 Education | $65.8M | 12 |
| MULTIPLIER | San Francisco | C60 Environment | $65.8M | 7 |
| Sacramento Region Community Foundation | Sacramento | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $65.8M | 5 |
| NORTHERN CALIFORNIA CARPENTERS REGIONAL COUNCIL | Oakland | — | $65.8M | 16 |
| MOJAVE RIVER ACADEMY SCHOOLS | Oro Grande | B29 Education | $65.7M | 17 |
| MERCY HOUSE LIVING CENTERS | Santa Ana | L410 Housing & Shelter | $65.4M | 6 |
| UC SANTA BARBARA FOUNDATION | Santa Barbara | B114 Education | $65.3M | 6 |
| HOMEBRIDGE INC | San Francisco | — | $65.2M | 11 |
| SAN FRANCISCO MUSEUM OF MODERN ART | San Francisco | A510 Arts, Culture & Humanities | $65.1M | 8 |
| BIOINDUSTRIAL MANUFACTURING AND DESIGN ECOSYSTEM INC | Emeryville | S40 Community Improvement & Capacity Building | $65.1M | 9 |
| FENTON CHARTER PUBLIC SCHOOLS | Sun Valley | B29 Education | $65.1M | 10 |
| MILKEN COMMUNITY SCHOOL | Los Angeles | — | $64.8M | 10 |
| A COMMUNITY OF FRIENDS | Los Angeles | L200 Housing & Shelter | $64.7M | 8 |
| RESNICK FOUNDATION | Los Angeles | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $64.7M | 0 |
