| METROPOLITAN EMPLOYEES BENEFITS | San Diego | — | $71.5M | 0 |
| AMERICAN YOUTH SOCCER ORGANIZATION | Torrance | N640 Recreation & Sports | $71.3M | 7 |
| TREVOR PROJECT INC | West Hollywood | R20 Civil Rights, Social Action & Advocacy | $71.2M | 13 |
| FEEDING AMERICA | Riverside | K31Z Food, Agriculture & Nutrition | $71.1M | 2 |
| PHILANTHROPIC VENTURES FOUNDATION | Oakland | T500 Philanthropy, Voluntarism & Grantmaking Foundations | $71M | 2 |
| CROSSROADS SCHOOL FOR ARTS AND SCIENCES | Santa Monica | B200 Education | $70.9M | 8 |
| RICHARD B FULLERTON FOUNDATION | San Francisco | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $70.9M | 0 |
| BY THE BAY Health | Larkspur | P74 Human Services | $70.9M | 12 |
| SHASTA COMMUNITY HEALTH CENTER | Redding | E32Z Health Care | $70.5M | 16 |
| Penny Lane Centers | North Hollywood | — | $70.5M | 7 |
| BRENTWOOD SCHOOL | Los Angeles | B200 Education | $70.3M | 9 |
| URBAN ALCHEMY | San Francisco | S99 Community Improvement & Capacity Building | $70.3M | 8 |
| Visa Foundation | San Francisco | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $70.2M | 0 |
| THE AHMANSON FOUNDATION | Beverly Hills | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $70M | 3 |
| TURNING POINT OF CENTRAL CALIFORNIA | Visalia | F300 Mental Health & Crisis Intervention | $70M | 8 |
| CATHOLIC CHARITIES DIOCESE OF SAN DIEGO | San Diego | P20Z Human Services | $70M | 7 |
| VAUGHN NEXT CENTURY LEARNING CENTER | San Fernando | B29 Education | $69.8M | 10 |
| WESTERN TEAMSTERS WELFARE TRUST | Pasadena | — | $69.7M | 0 |
| PRAGER UNIVERSITY FOUNDATION | Sherman Oaks | B99 Education | $69.7M | 11 |
| CAMBIAR EDUCATION | San Diego | B90 Education | $69.5M | 6 |
| BUCK INSTITUTE FOR RESEARCH ON AGING | Novato | V99 Social Science | $69.5M | 8 |
| LIFELONG LEARNING ADMINISTRATION | Lancaster | B29 Education | $69.4M | 13 |
| LOS ANGELES COUNTY FAIR ASSOCIATION | Pomona | — | $69.4M | 8 |
| Santa Barbara Cottage Hospital Foundation | Santa Barbara | E112 Health Care | $69.1M | 4 |
| TENDERLOIN HOUSING CLINIC INC | San Francisco | L52Z Housing & Shelter | $69M | 8 |
| Metropolitan Area Advisory Committee on Anti-Poverty of San Diego County In | Chula Vista | P40 Human Services | $68.6M | 12 |
| CALIFORNIA STATE UNIVERSITY LONG BEACH | Long Beach | B110 Education | $68.5M | 14 |
| GRANCELL VILLAGE OF THE LOS ANGELES | Reseda | P750 Human Services | $68.5M | 7 |
| AMERICAN ACADEMY OF OPHTHALMOLOGY INC | San Francisco | — | $68.3M | 28 |
| SOLANO FAMILY & CHILDRENS COUNCIL INC | Fairfield | P300 Human Services | $68.2M | 6 |
| ST VINCENT DE PAUL VILLAGE INC | San Diego | X20Z Religion-Related | $68.1M | 10 |
| MENLO SCHOOL | Atherton | — | $68.1M | 8 |
| THE ALBERTSONS COMPANIES FOUNDATION | Pleasanton | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $68.1M | 0 |
| SAINT AGNES MEDICAL FOUNDATION | Fresno | E110 Health Care | $68M | 5 |
| SAN FRANCISCO SYMPHONY | San Francisco | A690 Arts, Culture & Humanities | $67.8M | 7 |
| INTERNATIONAL BROTHERHOOD OF | Vacaville | — | $67.2M | 20 |
| Adventist Health Tulare | Tulare | — | $67.2M | 26 |
| PARKER INSTITUTE FOR CANCER IMMUNOTHERAPY | San Francisco | E12 Health Care | $66.9M | 8 |
| VENTURA COUNTY CREDIT UNION | Ventura | — | $66.7M | 24 |
| PERFORMING ARTS CENTER OF LOS ANGELES | Los Angeles | A610 Arts, Culture & Humanities | $66.6M | 11 |
| CHAPA-DE INDIAN HEALTH PROGRAM INC | Auburn | E39Z Health Care | $66.6M | 12 |
| BURNING MAN PROJECT | San Francisco | S20 Community Improvement & Capacity Building | $66.6M | 17 |
| ROOM TO READ | San Francisco | B90 Education | $66.5M | 9 |
| EDWARD CHARLES FOUNDATION | Beverly Hills | P99 Human Services | $66.5M | 0 |
| CREDIT UNIONS IN THE STATE OF CALIFORNIA | Yuba City | — | $66.4M | 11 |
| EAH Inc | San Rafael | L210 Housing & Shelter | $66.2M | 9 |
| Planned Parenthood Shasta-Diablo Inc | Concord | E420 Health Care | $66.1M | 8 |
| GALLO EMPLOYEE BENEFIT TRUST | Modesto | Z99 Unknown | $66.1M | 0 |
| Self-Help Enterprises | Visalia | L20Z Housing & Shelter | $66M | 10 |
| BIRMINGHAM COMMUNITY CHARTER HIGH SCHOOL | Van Nuys | B29 Education | $65.8M | 12 |
