| GOLDEN GATE UNIVERSITY | San Francisco | B430 Education | $46.8M | 13 |
| UCSF HEALTH MEDICAL FOUNDATION | Emeryville | E112 Health Care | $46.7M | 14 |
| LOS ANGELES OPERA COMPANY | Los Angeles | A6A0 Arts, Culture & Humanities | $46.6M | 13 |
| San Diego UNITE - HERE Health Fund | San Diego | — | $46.6M | 0 |
| CRYSTAL SPRINGS UPLANDS SCHOOL | Hillsborough | B25Z Education | $46.6M | 7 |
| THE CHILDREN'S CLINIC SERVING CHILDREN AND THEIR FAMILIES | Long Beach | — | $46.5M | 14 |
| HMTS INC | Newport Beach | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $46.4M | 2 |
| CASA DE LAS CAMPANAS INC | San Diego | P750 Human Services | $46.4M | 7 |
| INGLEWOOD PARK CEMETERY | Inglewood | — | $46.4M | 23 |
| TIDES NETWORK | San Francisco | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $46.3M | 12 |
| INTEL RETIREE MEDICAL PLAN TRUST | Santa Clara | — | $46.3M | 0 |
| CALIFORNIA UNIVERSITY OF SCIENCE AND MEDICINE | Colton | B43 Education | $46.3M | 19 |
| MADERA COMMUNITY HOSPITAL | Madera | E220 Health Care | $46.3M | 8 |
| SAGE HILL SCHOOL | Newport Coast | B200 Education | $46.3M | 7 |
| BEHAVIORAL HEALTH SERVICES INC | Gardena | F200 Mental Health & Crisis Intervention | $46.2M | 11 |
| Food Share Inc | Oxnard | K300 Food, Agriculture & Nutrition | $46.2M | 5 |
| CALIFORNIA WESTERN SCHOOL OF LAW | San Diego | B500 Education | $46.2M | 11 |
| ALPHA PROJECT FOR THE HOMELESS | San Diego | — | $46.1M | 9 |
| EQUITAS ACADEMY CHARTER SCHOOL | Los Angeles | B29 Education | $46.1M | 7 |
| THE RONALD REAGAN PRESIDENTIAL FOUNDATION AND INSTITUTE | Simi Valley | B110 Education | $46M | 14 |
| CALIFORNIA HEALTH FOUNDATION AND TRUST | Sacramento | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $46M | 2 |
| GRID ALTERNATIVES AFFILIATES & SUBSIDIARIES | Oakland | C35 Environment | $46M | 18 |
| THE SAN FRANCISCO SOCIETY FOR THE PREVENTION OF CRUELTY TO ANIMALS | San Francisco | D200 Animal-Related | $46M | 17 |
| SOUTH BAY WORKFORCE INVESTMENT BOARD INC | Hawthorne | B90 Education | $45.8M | 7 |
| CARPENTERS TRAINING TRUST FUND FOR NORTHERN CALIFORNIA | Oakland | J22I Employment | $45.6M | 6 |
| THE HIGH DESERT PARTNERSHIP IN ACADEMIC EXCELLENCE FOUNDATION INC | Apple Valley | B200 Education | $45.6M | 13 |
| Florence Crittenton Services of Orance County Inc | Fullerton | P730 Human Services | $45.6M | 8 |
| OPTIONS FOR YOUTH - ACTON INC | Pasadena | B60 Education | $45.5M | 5 |
| Quaye at Wellington Inc | San Francisco | Y11 Mutual & Membership Benefit | $45.4M | 0 |
| CEMENT MASONS HEALTH & WELFARE FUND FOR NORTHERN CALIFORNIA | Dublin | — | $45.3M | 2 |
| Native American Health Center Inc | Oakland | — | $45.2M | 10 |
| INTERNATIONAL UNION OF PAINTERS AND ALLIED TRADES DISTRICT COUNCIL 16 | Livermore | — | $45.2M | 13 |
| QUANTUM LEAP HEALTHCARE COLLABORATIVE | San Francisco | P20 Human Services | $45.1M | 11 |
| COMPLETE CARE COMMUNITY HEALTH CENTER I | Los Angeles | E20 Health Care | $45.1M | 9 |
| BABY2BABY | Los Angeles | Z99 Unknown | $45.1M | 7 |
| Central Valley Indian Health Inc | Clovis | E30Z Health Care | $45M | 21 |
| TIPPING POINT COMMUNITY | San Francisco | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $45M | 10 |
| LOS ANGELES JEWISH HOME FOR THE AGING | Reseda | S500 Community Improvement & Capacity Building | $44.9M | 12 |
| VENTURA COUNTY COMMUNITY FOUNDATION | Camarillo | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $44.9M | 6 |
| Da Vinci Schools | El Segundo | B29 Education | $44.8M | 5 |
| THE COTTONWOOD SCHOOL | El Dorado Hills | B29 Education | $44.8M | 7 |
| COMMUNITY ACTION PARTNERSHIP OF ORANGE COUNTY | Garden Grove | — | $44.7M | 6 |
| ASSOCIATED STUDENTS OF SDSU SAN DIEGO STATE UNIVERSITY | San Diego | — | $44.7M | 17 |
| COMMUNITY CHILD CARE COUNCIL OF SONOMA COUNTY INC | Santa Rosa | P33Z Human Services | $44.7M | 2 |
| High Desert & Inland Employee-Employer Trust | Apple Valley | — | $44.6M | 0 |
| THE WENDE MUSEUM OF THE COLD WAR INC | Culver City | A50 Arts, Culture & Humanities | $44.5M | 3 |
| MKA CHARITABLE FUND C/O ANDERSEN TAX LLC | San Francisco | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $44.5M | 0 |
| CALIFORNIA MEDICAL ASSOCIATION | Sacramento | — | $44.5M | 19 |
| ACCION OPPORTUNITY FUND COMMUNITY DEVELOPMENT | San Jose | S31 Community Improvement & Capacity Building | $44.5M | 14 |
| OCEAN GROVE CHARTER SCHOOL | Placerville | B29 Education | $44.5M | 6 |
