| Indianapolis Museum of Art Inc | Indianapolis | A510 Arts, Culture & Humanities | $62M | 10 |
| HANCOCK RURAL TELEPHONE CORPORATION | Greenfield | — | $61.8M | 25 |
| THE ENDOWMENT FUND OF THE PHI KAPPA PSI | Indianapolis | B82 Education | $61.6M | 3 |
| OAKLAWN PSYCHIATRIC CENTER INC | Goshen | F50 Mental Health & Crisis Intervention | $61M | 8 |
| GIBSON GENERAL HOSPITAL | Princeton | E22 Health Care | $59.7M | 13 |
| SOUTHLAKETRI-CITY MANAGEMENT | Merrillville | F30 Mental Health & Crisis Intervention | $59.3M | 7 |
| Our Sunday Visitor Inc | Huntington | X830 Religion-Related | $59.1M | 22 |
| COMMUNITY FOUNDATION | Elkhart | T31Z Philanthropy, Voluntarism & Grantmaking Foundations | $58.8M | 4 |
| KOSCIUSKO REMC | Warsaw | — | $58.7M | 17 |
| COMMUNITY HEALTH CLINIC INC | Topeka | E20 Health Care | $58.5M | 4 |
| AMERICAN CAMPING ASSOCIATION INC | Martinsville | — | $58.5M | 5 |
| Liberty Fund Inc | Carmel | — | $56.9M | 15 |
| ZETA TAU ALPHA FRATERNITY GROUP RETURN | Carmel | — | $56.7M | 1 |
| RUSHSHELBY ENERGY RURAL ELECTRIC | Manilla | W80 Public & Societal Benefit | $55.8M | 16 |
| Indiana University Health White Memorial Hospital Inc | Indianapolis | E20 Health Care | $55.2M | 21 |
| Lumina Foundation for Education Inc | Indianapolis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $54.3M | 21 |
| Elevance Health Foundation Inc | Indianapolis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $53.9M | 0 |
| Pipe Trades Industry Health and Welfare | Terre Haute | — | $53.9M | 1 |
| INDIANA ONLINE LEARNING OPTIONS INC | Indianapolis | B29 Education | $53.8M | 1 |
| ELECTRICAL WORKERS BENEFIT TRUST FUND | Indianapolis | — | $53.6M | 5 |
| Financial Center First Credit Union | Indianapolis | W61 Public & Societal Benefit | $53.6M | 37 |
| Franklin College of Indiana | Franklin | B420 Education | $53.5M | 7 |
| ELI LILLY & CO MASTER TRUST FOR | Indianapolis | — | $53.3M | 1 |
| LUTHERAN HOMES INC | Fort Wayne | P75 Human Services | $53.2M | 7 |
| HAMILTON CENTER INC | Terre Haute | F33 Mental Health & Crisis Intervention | $53.1M | 6 |
| POLICE AND FIREMENS INSURANCE ASSOCIATION | Carmel | — | $53M | 20 |
| BARTHOLOMEW COUNTY REMC | Columbus | — | $52.5M | 14 |
| GOODWILL INDUSTRIES OF MICHIANA INC | South Bend | J320 Employment | $52.2M | 7 |
| Crane Credit Union | Odon | — | $51.8M | 19 |
| ANTHONY WAYNE REHABILITATION CENTER | Fort Wayne | E50Z Health Care | $51.7M | 9 |
| Huntington University | Huntington | B420 Education | $51.1M | 9 |
| Carroll White REMC | Monticello | W80 Public & Societal Benefit | $51M | 13 |
| CREDIT UNION TRUST | Indianapolis | Y43 Mutual & Membership Benefit | $50.9M | 0 |
| INDIANAPOLIS ZOOLOGICAL SOCIETY INC | Indianapolis | D500 Animal-Related | $50.1M | 9 |
| The Children's Museum of Indianapolis Inc | Indianapolis | A520 Arts, Culture & Humanities | $49.8M | 8 |
| THE MIND TRUST INC | Indianapolis | B052 Education | $49.3M | 11 |
| UTILITIES DISTRICT OF WESTERN | Bloomfield | — | $49.2M | 18 |
| DEPARTMENT OF FINANCIAL INSTITUTION DIV | Bedford | — | $49M | 9 |
| Goshen College Inc | Goshen | B42 Education | $48.8M | 5 |
| JANE PAULEY COMMUNITY HEALTH CENTER INC | Indianapolis | E32 Health Care | $48.3M | 9 |
| WV-WCI SCHOOL TRUST | Logansport | — | $48.2M | 1 |
| PORTER COUNTY SCHOOL EMPLOYEES' INSURANCE TRUST | Valparaiso | Y44 Mutual & Membership Benefit | $47.8M | 0 |
| PARK CENTER INC | Fort Wayne | F320 Mental Health & Crisis Intervention | $47.7M | 11 |
| Rehabilitation Hospital of Indiana Inc | Indianapolis | E50Z Health Care | $47.1M | 14 |
| Indiana University Health Tipton Hospital Inc | Indianapolis | E20 Health Care | $47.1M | 15 |
| ADULT & CHILD MENTAL HEALTH CENTER INC | Indianapolis | F32Z Mental Health & Crisis Intervention | $46.8M | 12 |
| CHILDREN'S BUREAU INC | Indianapolis | P30 Human Services | $46.7M | 7 |
| IBA GROUP INSURANCE TRUST | Indianapolis | — | $46.7M | 0 |
| Indiana University Health Foundation Inc | Indianapolis | E11 Health Care | $45.8M | 9 |
| PLUMBERS AND STEAMFITTERS LOCAL 440 | Lafayette | — | $45.4M | 0 |
