| OAKLAWN PSYCHIATRIC CENTER INC | Goshen | F50 Mental Health & Crisis Intervention | $62.7M | 8 |
| ELECTRICAL WORKERS BENEFIT TRUST FUND | Indianapolis | — | $62.4M | 6 |
| HANCOCK RURAL TELEPHONE CORPORATION DBA NINESTAR CONNECT | Greenfield | — | $61.8M | 25 |
| COMMUNITY FOUNDATION OF ST JOSEPH COUNTY INC | South Bend | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $61.3M | 3 |
| GIBSON GENERAL HOSPITAL | Princeton | E22 Health Care | $59.7M | 13 |
| Our Sunday Visitor Inc | Huntington | X830 Religion-Related | $59.1M | 22 |
| COMMUNITY FOUNDATION OF ELKHART COUNTY INC | Elkhart | T31Z Philanthropy, Voluntarism & Grantmaking Foundations | $58.8M | 4 |
| KOSCIUSKO REMC | Warsaw | — | $58.7M | 17 |
| The American Legion | Indianapolis | — | $58.6M | 15 |
| COMMUNITY HEALTH CLINIC INC | Topeka | E20 Health Care | $58.5M | 4 |
| THE MIND TRUST INC | Indianapolis | B052 Education | $57.9M | 12 |
| Pipe Trades Industry Health and Welfare Plan | Terre Haute | — | $57.9M | 1 |
| Liberty Fund Inc | Carmel | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $56.9M | 15 |
| ZETA TAU ALPHA FRATERNITY GROUP RETURN | Carmel | — | $56.7M | 1 |
| SAINT JOSEPH REGIONAL MEDICAL CENTER - PLYMOUTH CAMPUS INC | Mishawaka | E220 Health Care | $56.5M | 15 |
| SOUTHLAKETRI-CITY MANAGEMENT CORPORATION DBA GEMINUS CORPORATION | Merrillville | F30 Mental Health & Crisis Intervention | $56.4M | 8 |
| Indiana University Health White Memorial Hospital Inc | Indianapolis | E20 Health Care | $56.1M | 23 |
| RUSHSHELBY ENERGY RURAL ELECTRIC MEMBERSHIP CORPORATION | Manilla | W80 Public & Societal Benefit | $55.8M | 16 |
| ANTHONY WAYNE REHABILITATION CENTER FOR HANDICAPPED AND BLIND INC | Fort Wayne | E50Z Health Care | $55.6M | 12 |
| DEPARTMENT OF FINANCIAL INSTITUTION DIV HOOSIER HILLS CREDIT UNION | Bedford | — | $55.4M | 9 |
| Lumina Foundation for Education Inc | Indianapolis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $54.3M | 21 |
| Elevance Health Foundation Inc | Indianapolis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $53.9M | 0 |
| INDIANA ONLINE LEARNING OPTIONS INC | Indianapolis | B29 Education | $53.8M | 1 |
| Huntington University | Huntington | B420 Education | $53.8M | 9 |
| CARROLL WHITE REMC | Monticello | W80 Public & Societal Benefit | $53.8M | 13 |
| Financial Center First Credit Union | Indianapolis | W61 Public & Societal Benefit | $53.6M | 37 |
| Goshen College Inc | Goshen | B42 Education | $53.6M | 4 |
| Franklin College of Indiana | Franklin | B420 Education | $53.5M | 7 |
| CREDIT UNION TRUST | Indianapolis | Y43 Mutual & Membership Benefit | $53.4M | 0 |
| POLICE AND FIREMENS INSURANCE ASSOCIATION | Carmel | — | $53M | 20 |
| BARTHOLOMEW COUNTY REMC | Columbus | — | $52.5M | 14 |
| Crane Credit Union | Odon | — | $51.8M | 19 |
| UTILITIES DISTRICT OF WESTERN INDIANA REMC | Bloomfield | — | $51M | 17 |
| GOODWILL INDUSTRIES OF MICHIANA INC | South Bend | J320 Employment | $50.8M | 7 |
| Indianapolis Museum of Art Inc | Indianapolis | A510 Arts, Culture & Humanities | $50.7M | 9 |
| Adult & Child Health Inc | Indianapolis | F32Z Mental Health & Crisis Intervention | $50.5M | 17 |
| INDIANAPOLIS ZOOLOGICAL SOCIETY INC | Indianapolis | D500 Animal-Related | $50.1M | 9 |
| The Children's Museum of Indianapolis Inc | Indianapolis | A520 Arts, Culture & Humanities | $49.8M | 8 |
| IBA GROUP INSURANCE TRUST | Indianapolis | — | $49.3M | 0 |
| Indiana University Health Tipton Hospital Inc | Indianapolis | E20 Health Care | $49.1M | 14 |
| LUTHERAN HOMES INC | Fort Wayne | P75 Human Services | $48.7M | 9 |
| HAMILTON CENTER INC | Terre Haute | F33 Mental Health & Crisis Intervention | $48.3M | 6 |
| JANE PAULEY COMMUNITY HEALTH CENTER INC | Indianapolis | E32 Health Care | $48.3M | 9 |
| WV-WCI SCHOOL TRUST | Logansport | — | $48.2M | 1 |
| PARK CENTER INC | Fort Wayne | F320 Mental Health & Crisis Intervention | $47.7M | 11 |
| Anthem Supplemental Unemployment Benefit Trust | Indianapolis | Y24 Mutual & Membership Benefit | $47.6M | 1 |
| PORTER COUNTY SCHOOL EMPLOYEES' INSURANCE TRUST | Valparaiso | Y44 Mutual & Membership Benefit | $47.5M | 0 |
| INSTITUTE FOR STUDY ABROAD INC | Indianapolis | Q220 International, Foreign Affairs & National Security | $47.4M | 8 |
| Rehabilitation Hospital of Indiana Inc | Indianapolis | E50Z Health Care | $47.1M | 14 |
| KANKAKEE VALLEY RURAL ELECTRIC MEMBERSHIP CORPORATION | Wanatah | — | $47M | 13 |
