| CHILDREN'S BUREAU INC | Indianapolis | P30 Human Services | $46.7M | 7 |
| PHP FOUNDATION INC | Fort Wayne | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $46.4M | 1 |
| Indiana University Health Foundation Inc | Indianapolis | E11 Health Care | $45.8M | 9 |
| SOUTHLAKE COMMUNITY MENTAL HEALTH CENTER | Merrillville | F32Z Mental Health & Crisis Intervention | $45.7M | 11 |
| PLUMBERS AND STEAMFITTERS LOCAL 440 HEALTH & WELFARE PLAN | Lafayette | — | $45.4M | 0 |
| NORTHERN INDIANA PUBLIC SERVICE COMPANY HEALTH & MEDICAL BEN TR | Merrillville | — | $45.4M | 0 |
| DAVIESS-MARTIN COUNTY REMC | Loogootee | — | $44.5M | 18 |
| SOUTHERN INDIANA REC INC | Tell City | W80 Public & Societal Benefit | $44.4M | 13 |
| LIFESPRING INC | Jeffersonville | F32Z Mental Health & Crisis Intervention | $44.4M | 17 |
| ASPIRE INDIANA INC | Noblesville | F320 Mental Health & Crisis Intervention | $44.2M | 20 |
| JOHN W ANDERSON FOUNDATION | Valparaiso | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $43.8M | 5 |
| BETHEL UNIVERSITY INC | Mishawaka | B420 Education | $43.4M | 6 |
| LEGACY FOUNDATION INC | Merrillville | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $43.1M | 1 |
| INDIANA HEALTH CENTERS INC | Indianapolis | E320 Health Care | $42.9M | 12 |
| INDIANAPOLIS MOTOR SPEEDWAY FOUNDATION INC | Indianapolis | — | $42.6M | 3 |
| DECATUR COUNTY RURAL ELECTRIC MEMBER | Greensburg | — | $42.3M | 14 |
| GOODWILL EDUCATION INITIATIVES INC | Indianapolis | B240 Education | $41.2M | 9 |
| COMMUNITY HOSPITAL OF LAGRANGE COUNTY INC | LaGrange | E22 Health Care | $41M | 17 |
| VALLEY PROFESSIONALS COMMUNITY HEALTH CENTER INC | Clinton | E20 Health Care | $40.5M | 14 |
| IVY TECH FOUNDATION INC | Indianapolis | B114 Education | $40.3M | 6 |
| USA Gymnastics | Indianapolis | N700 Recreation & Sports | $40.2M | 14 |
| GREENCROFT GOSHEN INC | Goshen | P750 Human Services | $40.1M | 6 |
| DSI DIVERSIFIED SOLUTIONS INC | Columbus | L19 Housing & Shelter | $40M | 4 |
| CRF AFFORDABLE HOUSING INC | Plainfield | L20 Housing & Shelter | $39.9M | 2 |
| AFFORDABLE HOUSING PARTNERS INC | Carmel | L200 Housing & Shelter | $39.7M | 1 |
| DEBORAH JOY SIMON CHARITABLE FOUNDATION | Carmel | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $39.7M | 0 |
| INDIANA HEMOPHILIA & THROMBOSIS CENTER INC | Indianapolis | E20 Health Care | $39.4M | 20 |
| KAPPA ALPHA THETA FRATERNITY GROUP RETURN | Indianapolis | — | $39.4M | 2 |
| FOUNDATION FOR ADVANCED PHILANTHROPY INC | Indianapolis | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $39.3M | 1 |
| DUBOIS RURAL ELECTRIC COOPERATIVE INC | Jasper | — | $39.2M | 14 |
| CHOICES COORDINATED CARE SOLUTIONS INC | Indianapolis | P300 Human Services | $39.2M | 7 |
| Indiana University Health Jay Inc | Indianapolis | E20 Health Care | $39.1M | 16 |
| AMERICAN UNITED LIFE INS CO WELFARE BENEFITS PLAN FOR HOME OFFICE EMPLOYEES | Indianapolis | Y20 Mutual & Membership Benefit | $39M | 0 |
| Allen Whitehill Clowes Charitable Foundation Inc | Indianapolis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $38.9M | 9 |
| 219 Health Network Inc | East Chicago | E22 Health Care | $38.4M | 2 |
| National Security Technology Accelerator | Crane | M02 Public Safety, Disaster Preparedness & Relief | $38.2M | 3 |
| AMERICAN SENIOR COMMUNITIES GROUP HEALTH PLAN | Indianapolis | — | $38.1M | 0 |
| FRANCISCAN HEALTH RENSSELAER INC | Rensselaer | — | $37.9M | 8 |
| SOUTHEASTERN INDIANA RURAL ELECTRIC MEMBERSHIP CORPORATION | Osgood | — | $37.9M | 16 |
| Northwest Indiana Community Action Corporation | Crown Point | S21 Community Improvement & Capacity Building | $37.4M | 4 |
| Indiana University Health Paoli Inc | Indianapolis | E20 Health Care | $37.3M | 19 |
| CENTRAL INDIANA SCHOOL EMPLOYEES' INSURANCE TRUST | Carmel | — | $37.3M | 0 |
| CICOA Aging & In-Home Solutions Inc | Indianapolis | P81Z Human Services | $37.3M | 6 |
| PORTER-STARKE SERVICES INC | Valparaiso | F300 Mental Health & Crisis Intervention | $37.1M | 8 |
| ELI LILLY AND COMPANY FOUNDATION | Indianapolis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $36.8M | 0 |
| HILLS INSURANCE COMPANY INC C/O FRANCISCAN ALLIANCE INC | Mishawaka | Y200 Mutual & Membership Benefit | $36.8M | 3 |
| HANCOCK PHYSICIAN NETWORK LLC | Greenfield | — | $36.7M | 10 |
| VALLEY OAKS HEALTH INC | Lafayette | E22 Health Care | $36.6M | 25 |
| JASPER COUNTY RURAL ELECTRIC MEMBERSHIP CORPORATION | Rensselaer | — | $36.3M | 13 |
| The Cummins Foundation Inc | Columbus | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $36.1M | 0 |
