| CUMMINS BEHAVIORAL HEALTH SYSTEMS INC | Avon | F30Z Mental Health & Crisis Intervention | $28M | 8 |
| CARDINAL SERVICES INC OF INDIANA | Warsaw | B82 Education | $28M | 5 |
| Community Hospital of Bremen Inc | Bremen | E22Z Health Care | $28M | 12 |
| Southwestern Behavioral Healthcare Inc | Evansville | F30Z Mental Health & Crisis Intervention | $28M | 9 |
| ORANGE COUNTY RURAL ELECTRIC MEMBERSHIP CORPORATION | Orleans | — | $27.9M | 14 |
| Conner Prairie Foundation Inc | Fishers | A11 Arts, Culture & Humanities | $27.6M | 0 |
| THE ESTELLE PEABODY MEMORIAL HOME INC | North Manchester | P750 Human Services | $27.4M | 6 |
| WHITE'S RESIDENTIAL & FAMILY SERVICES INC | Wabash | P300 Human Services | $27.3M | 4 |
| NOBLE COUNTY RURAL ELECTRIC MEMBERSHIP CORP | Albion | — | $27.2M | 16 |
| TURNING POINT ACTION INC | Indianapolis | — | $27.2M | 2 |
| INDIANAPOLIS JEWISH HOME INC | Indianapolis | E91Z Health Care | $27.2M | 8 |
| COMMUNITY HARVEST FOOD BANK OF NORTHEAST INDIANA INC | Fort Wayne | K310 Food, Agriculture & Nutrition | $27M | 1 |
| HARRISON COUNTY COMMUNITY FOUNDATION SUPPORTING ORGANIZATION INC | Corydon | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $27M | 2 |
| REC Holding Building Corp | Rushville | S99 Community Improvement & Capacity Building | $26.9M | 0 |
| THE FRANKLIN UNITED METHODIST HOME INC | Franklin | P750 Human Services | $26.8M | 10 |
| FOOD BANK OF NORTHERN INDIANA INC | South Bend | K310 Food, Agriculture & Nutrition | $26.7M | 2 |
| LITTLE STAR CENTER INC | Carmel | B28 Education | $26.6M | 8 |
| BARNES & THORNBURG VOLUNTARY EMPLOYEE BENEFICIARY ASSOCIATION TRUST | Indianapolis | — | $26.5M | 1 |
| CENTERSTONE HEALTH SERVICES INC | Bloomington | E32Z Health Care | $26.4M | 1 |
| Indianapolis Private Industry Council | Indianapolis | J20Z Employment | $26.2M | 9 |
| Independent Colleges of Indiana Inc | Indianapolis | B03 Education | $25.9M | 31 |
| VIA Credit Union | Marion | W61 Public & Societal Benefit | $25.8M | 7 |
| PATHFINDER SERVICES INC | Huntington | — | $25.7M | 2 |
| WHEELER MISSION MINISTRIES INC | Indianapolis | P20 Human Services | $25.5M | 6 |
| HERRON HIGH SCHOOL INC | Indianapolis | B29 Education | $25M | 7 |
| Indiana Legal Services Inc | Indianapolis | I80 Crime & Legal-Related | $24.7M | 4 |
| Regenstrief Institute Inc | Indianapolis | B054 Education | $24.7M | 11 |
| WINDROSE HEALTH NETWORK INC | Trafalgar | E32 Health Care | $24.5M | 9 |
| NATIONAL ASSOCIATION OF MUTUAL INSURANCE COMPANIES INC | Indianapolis | — | $24.4M | 11 |
| HERITAGE CHRISTIAN SCHOOLS INC | Indianapolis | B24Z Education | $24.3M | 4 |
| OPPORTUNITY ENTERPRISES INC | Valparaiso | J330 Employment | $24.3M | 7 |
| Neighborhood Health Clinics Inc | Fort Wayne | E30 Health Care | $24.3M | 9 |
| STONE BELT ARC INC | Bloomington | P82Z Human Services | $24.2M | 2 |
| SECOND HARVEST FOOD BANK OF EAST CENTRAL INDIANA INC | Muncie | K31Z Food, Agriculture & Nutrition | $24.1M | 1 |
| ADEC INC | Bristol | P80 Human Services | $24M | 5 |
| JAY COUNTY RURAL ELECTRIC MEMBERSHIP CORPORATION | Portland | — | $24M | 15 |
| FOELLINGER FOUNDATION INC | Fort Wayne | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $23.9M | 8 |
| FAIRBANKS HOSPITAL INC | Indianapolis | F220 Mental Health & Crisis Intervention | $23.8M | 10 |
| Oakland City University | Oakland City | B420 Education | $23.7M | 4 |
| Open Door Health Services Inc | Muncie | E30 Health Care | $23.7M | 9 |
| COMMUNITY FOUNDATION OF HANCOCK COUNTY INC | Greenfield | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $23.6M | 1 |
| AVONDALE MEADOWS ACADEMY INC D/B/A UNITED SCHOOLS OF INDIANAPOLIS | Indianapolis | B29 Education | $23.6M | 1 |
| CENTRAL INDIANA EDUCATIONAL SERVICE CENT | Indianapolis | B02 Education | $23.4M | 1 |
| INDIANA SYMPHONY SOCIETY INC | Indianapolis | A690 Arts, Culture & Humanities | $23.4M | 8 |
| HAMILTON COUNTY COMMUNITY FOUNDATION INC | Fishers | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $23.3M | 8 |
| SAGAMORE INSTITUTE INC | Indianapolis | W05 Public & Societal Benefit | $23.2M | 9 |
| COMMUNITY HOME HEALTH SERVICES INC | Fishers | E92 Health Care | $23M | 10 |
| INDIANA SPORTS CORPORATION | Indianapolis | N70 Recreation & Sports | $22.8M | 7 |
| National FFA Foundation Inc | Indianapolis | O52Z Youth Development | $22.8M | 7 |
| MIAMI-CASS COUNTY RURAL ELECTRIC MEMBERSHIP CORPORATION | Peru | — | $22.7M | 13 |
