| St John Sapulpa Inc | St Louis | E22Z Health Care | $28.3M | 7 |
| JAMES S MCDONNELL FOUNDATION | St Louis | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $28.2M | 1 |
| Catholic Health Association of the United States | Saint Louis | E010 Health Care | $28M | 11 |
| The Lutheran Home for the Aged | Cape Girardeau | — | $27.7M | 5 |
| CENTRAL BANCOMPANY INC VOLUNTARY EMPLOYEES BENEFICIARY ASSN | Jefferson Cty | — | $27.7M | 0 |
| ALEXIAN VILLAGE OF TENNESSEE | St Louis | P750 Human Services | $27.6M | 11 |
| ST VINCENT HEALTH WELLNESS AND PREVENTIVE CARE INSTITUTE INC | St Louis | E02 Health Care | $27.5M | 11 |
| BETTY JEAN KERR PEOPLE'S HEALTH CENTERS | St Louis | E32Z Health Care | $27.5M | 12 |
| HUMANE SOCIETY OF MISSOURI | St Louis | D20 Animal-Related | $27.2M | 8 |
| THE FOOD BANK FOR CENTRAL & NORTHEAST MISSOURI | Columbia | K31 Food, Agriculture & Nutrition | $26.7M | 0 |
| CHARLES N SHARPE JR FOUNDATION | Smithville | X11 Religion-Related | $26.6M | 0 |
| ASCENSION VIA CHRISTI REHABILITATION HOSPITAL INC | St Louis | E22 Health Care | $26.6M | 11 |
| MERCY HOSPITAL CASSVILLE | Cassville | E210 Health Care | $26.4M | 14 |
| RICHLAND MEDICAL CENTER D/B/A CENTRAL OZARKS MEDICAL CENTER | Richland | — | $26.2M | 8 |
| HOWELL OREGON ELECTRIC COOPERATIVE INC | West Plains | — | $26.1M | 20 |
| GATEWAY SCIENCE ACADEMY OF ST LOUIS | St Louis | B20 Education | $26.1M | 5 |
| JEWISH COMMUNITY CENTER | St Louis | P280 Human Services | $26.1M | 11 |
| Community Hospital Association Inc | Fairfax | E22 Health Care | $26.1M | 8 |
| Seton Medical Group Inc | St Louis | E60 Health Care | $26M | 21 |
| TRI-COUNTY MENTAL HEALTH SERVICES INC | Kansas City | F99Z Mental Health & Crisis Intervention | $26M | 9 |
| NAZARETH LIVING CENTER | St Louis | E910 Health Care | $26M | 7 |
| ARSENAL CREDIT UNION | Arnold | — | $25.9M | 13 |
| ST VINCENT MADISON COUNTY HEALTH SYSTEM INC | St Louis | E22Z Health Care | $25.8M | 15 |
| KC PEOPLE'S FUND | Kansas City | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $25.6M | 3 |
| CENTRAL MISSOURI COMMUNITY ACTION | Columbia | — | $25.6M | 2 |
| HAGAN SCHOLARSHIP FOUNDATION | Columbia | B82 Education | $25.6M | 0 |
| BELLERIVE COUNTRY CLUB | Saint Louis | — | $25.5M | 6 |
| SOUTHEAST MISSOURI HEALTH NETWORK | Benton | — | $25.5M | 11 |
| Genesys Ambulatory Health Services | St Louis | E320 Health Care | $25.5M | 9 |
| HOPE EDUCATIONAL & RESEARCH CENTER | St Louis | B20 Education | $25.5M | 7 |
| ST ANDREWS RESOURCES FOR SENIORS | St Louis | P750 Human Services | $25.3M | 6 |
| LUTHERAN SENIOR SERVICES ENDOWMENT FUND | St Louis | — | $25.3M | 12 |
| Assemblies of God Credit Union | Springfield | — | $25.1M | 10 |
| BETHESDA SENIOR LIVING INC | St Louis | L220 Housing & Shelter | $25M | 14 |
| St Vincent Jennings Hospital Inc | St Louis | E21Z Health Care | $24.9M | 14 |
| Gascosage Electric Cooperative | Dixon | — | $24.8M | 16 |
| CARROLL MANOR | St Louis | — | $24.7M | 12 |
| Baptist Health Care Affiliates inc | St Louis | E110 Health Care | $24.6M | 7 |
| AMERICAN ASSOCIATION OF ORTHODONTISTS | St Louis | — | $24.6M | 23 |
| SOUTHEAST MISSOURI FOOD BANK INC | Sikeston | K31Z Food, Agriculture & Nutrition | $24.6M | 1 |
| COTTEY COLLEGE | Nevada | B410 Education | $24.5M | 5 |
| MURIEL MCBRIEN KAUFFMAN FAMILY FOUNDATION | Kansas City | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $24.5M | 10 |
| NATIONAL WWI MUSEUM AND MEMORIAL | Kansas City | A800 Arts, Culture & Humanities | $24.4M | 5 |
| EWING MARION KAUFFMAN SCHOOL INC | Kansas City | B29 Education | $24.1M | 5 |
| Herschend Family Entertainment Employees Beneficiary Trust | Branson West | — | $24M | 0 |
| AIDS PROJECT OF THE OZARKS | Springfield | G81Z Diseases, Disorders & Medical Disciplines | $23.9M | 4 |
| City Union Mission | Kansas City | L410 Housing & Shelter | $23.9M | 3 |
| CARPENTERS VACATION TRUST FUND OF ST LOUIS | St Louis | — | $23.8M | 0 |
| MO-KAN IRON WORKERS WELFARE FUND | Kansas City | — | $23.8M | 0 |
| INTERNATIONAL BROTHERHOOD OF ELECTRICAL WORKERS LOCAL UNION 124 | Kansas City | — | $23.7M | 21 |
