| Max McGraw Wildlife Foundation | Dundee | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $11.3M | 3 |
| CME GROUP FOUNDATION | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $11.2M | 0 |
| DEPAUL COLLEGE PREP FOUNDATION | Chicago | B11 Education | $11.2M | 1 |
| SENIOR SERVICES ASSOCIATES INC | Elgin | — | $11.2M | 1 |
| NORTH SHORE COUNTRY CLUB | Glenview | — | $11.2M | 8 |
| GREENHEART INTERNATIONAL | Chicago | Q220 International, Foreign Affairs & National Security | $11.2M | 0 |
| APOSTOLIC CHRISTIAN HOME OF EUREKA | Eureka | E910 Health Care | $11.2M | 3 |
| Klaff Family Foundation c/o Rita Sawyer | Chicago | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $11.1M | 0 |
| THE CHICAGO MATH & SCIENCE ACADEMY CHARTER SCHOOL | Chicago | B29 Education | $11.1M | 2 |
| PIONEER CONCEPTS INC | Galesburg | L99 Housing & Shelter | $11.1M | 0 |
| ACCREDITATION COUNCIL FOR CONTINUING MEDICAL EDUCATION | Chicago | B60 Education | $11.1M | 7 |
| COMMUNITY LINK INC | Breese | P820 Human Services | $11.1M | 0 |
| AMERICAN MEDICAL TECHNOLOGISTS | Rosemont | — | $11.1M | 20 |
| RI & SL Wilson Foundation | Tremont | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $11.1M | 0 |
| AMERICAN ACADEMY OF PEDIATRIC DENTISTRY | Chicago | S41 Community Improvement & Capacity Building | $11.1M | 14 |
| AMERICAN SOCIETY OF NEURORADIOLOGY | Oak Brook | — | $11.1M | 8 |
| Center for REALTOR Development Inc | Chicago | — | $11.1M | 11 |
| LUTHERAN HOME FOR THE AGED DEVELOPMENT CORPORATION | Danforth | — | $11M | 3 |
| SUE LING GIN FOUNDATION TRUST | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $11M | 1 |
| FIELD FOUNDATION OF ILLINOIS | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $11M | 2 |
| PARK PLACE CHRISTIAN COMMUNITY OF ST JOHN INC | Tinley Park | P75 Human Services | $11M | 4 |
| WESTERN EGYPTIAN ECONOMIC OPPORTUNITY COUNCIL INC | Steeleville | P200 Human Services | $11M | 2 |
| THE CHICAGO CLUB | Chicago | — | $11M | 6 |
| JAMES S AND PAULA H CROWN FAMILY FOUNDAT | Chicago | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $11M | 0 |
| N2 STONE FOUNDATION | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $11M | 0 |
| HOUSING OPPORTUNITIES FOR WOMEN INC | Chicago | L40Z Housing & Shelter | $10.9M | 4 |
| FEDERAL DEFENDER PROGRAM INC | Chicago | — | $10.9M | 6 |
| ENVIRONMENTAL LAW AND POLICY CENTER OF THE MIDWEST | Chicago | C30Z Environment | $10.9M | 11 |
| WILLOWS HEALTH CENTER | Rockford | E910 Health Care | $10.9M | 4 |
| PEPPER FAMILY FOUNDATION | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $10.9M | 7 |
| NEWMAN FOUNDATION AT THE UNIVERSITY OF ILLINOIS | Champaign | — | $10.9M | 2 |
| THE NEWBERRY LIBRARY | Chicago | B700 Education | $10.9M | 9 |
| TRUENU | Bartlett | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $10.9M | 1 |
| Dominion Energy Inc Transmission Union VEBA TRUST | Chicago | Y430 Mutual & Membership Benefit | $10.9M | 1 |
| COMMUNITY ACTION PARTNERSHIP OF CENTRAL ILLINOIS INC | Lincoln | P200 Human Services | $10.9M | 1 |
| SAFE FAMILIES FOR CHILDREN ALLIANCE | Chicago | P30 Human Services | $10.9M | 3 |
| BILL BARTHOLOMAY FOUNDATION C/O TIMOTHY DEBRUYNE | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $10.8M | 0 |
| NORTHERN ILLINOIS BLOOD BANK INC D/B/A ROCK RIVER VALLEY BLOOD CENTER | Rockford | E61Z Health Care | $10.8M | 4 |
| YOUTH OUTREACH SERVICES INC | Chicago | P300 Human Services | $10.8M | 2 |
| VIVO FOUNDATION | Northbrook | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $10.8M | 0 |
| ROMANIAN AMERICAN COMMUNITY CENTER | Chicago | P81 Human Services | $10.8M | 2 |
| MIDWEST REGION ORGANIZING COMMITTEE | Springfield | J40 Employment | $10.8M | 7 |
| RIVER FOREST COUNTRY CLUB | Elmhurst | N50 Recreation & Sports | $10.8M | 6 |
| THE CHICAGO COUNCIL ON GLOBAL AFFAIRS | Chicago | Q050 International, Foreign Affairs & National Security | $10.8M | 8 |
| MERCYHEALTH VISITING NURSES ASSOCIATION INC | Rockford | E92Z Health Care | $10.8M | 10 |
| NORTHERN KANE EDUCATIONAL CORP | Pingree Grove | B29 Education | $10.8M | 5 |
| ALZHEIMER'S IMPACT MOVEMENT | Chicago | G83 Diseases, Disorders & Medical Disciplines | $10.8M | 6 |
| MERCY CIRCLE | Chicago | — | $10.8M | 2 |
| CHICAGO PAINTERS AND DECORATORS RETIREE WELFARE FUND | Darien | Y43 Mutual & Membership Benefit | $10.8M | 4 |
| Muslim Community Center | Chicago | X40Z Religion-Related | $10.8M | 3 |
