| Indiana University Health Inc | Indianapolis | E220 Health Care | $5.8B | 26 |
| Lilly Cares Foundation Inc | Indianapolis | P99Z Human Services | $4.1B | 0 |
| FRANCISCAN ALLIANCE INC | Mishawaka | E210 Health Care | $3.5B | 10 |
| MORGAN STANLEY GLOBAL IMPACT FUNDING TRUST INC | Indianapolis | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $3.1B | 0 |
| University of Notre Dame du Lac | Notre Dame | B430 Education | $2.6B | 15 |
| COMMUNITY HEALTH NETWORK INC | Indianapolis | E20 Health Care | $2.2B | 24 |
| LILLY ENDOWMENT INC | Indianapolis | — | $2.1B | 18 |
| PARKVIEW HOSPITAL INC | Fort Wayne | E220 Health Care | $1.9B | 39 |
| MDWISE MEDICAID NETWORK INC | Indianapolis | E80 Health Care | $1.9B | 6 |
| MDWISE INC | Indianapolis | — | $1.8B | 16 |
| DEACONESS HOSPITAL INC | Evansville | E220 Health Care | $1.5B | 19 |
| Renaissance Charitable Foundation Inc | Indianapolis | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $1.5B | 0 |
| National Collegiate Athletic Association | Indianapolis | N400 Recreation & Sports | $1.3B | 18 |
| Indiana University Health Care Associates Inc | Indianapolis | E31Z Health Care | $1.3B | 22 |
| PARKVIEW HEALTH SYSTEM INC | Fort Wayne | E210 Health Care | $1.1B | 55 |
| WABASH VALLEY POWER ASSOCIATION INC | Indianapolis | — | $805.6M | 35 |
| Indiana University Health Bloomington Inc | Indianapolis | E220 Health Care | $773M | 21 |
| UNION HOSPITAL INC | Terre Haute | E220 Health Care | $737.9M | 18 |
| Memorial Hospital of South Bend Inc | South Bend | E220 Health Care | $730.5M | 18 |
| Munster Medical Research Foundation Inc | Munster | E220 Health Care | $697.4M | 9 |
| Indiana University Health Arnett Inc | Indianapolis | E21 Health Care | $641.5M | 21 |
| Indiana University Health Ball Memorial Hospital Inc | Indianapolis | E220 Health Care | $604.6M | 17 |
| Reid Hospital & Health Care Services Inc | Richmond | E220 Health Care | $594.2M | 25 |
| MIDCONTINENT INDEPENDENT SYSTEM | Carmel | W80 Public & Societal Benefit | $548.6M | 28 |
| Indiana University Health North Hospital Inc | Indianapolis | E300 Health Care | $487.2M | 21 |
| THE METHODIST HOSPITALS INC | Gary | E220 Health Care | $472.2M | 23 |
| Indiana University Foundation | Bloomington | B110 Education | $426.1M | 14 |
| COMMUNITY PHYSICIANS | Indianapolis | E20 Health Care | $420M | 20 |
| ELI LILLY & COMPANY MASTER TRUST | Indianapolis | Y43 Mutual & Membership Benefit | $418.3M | 1 |
| DEACONESS HEALTH SYSTEM INC | Evansville | E110 Health Care | $398.1M | 28 |
| Indiana University Health West Hospital Inc | Indianapolis | E220 Health Care | $383.4M | 19 |
| SAINT JOSEPH REGIONAL MEDICAL CENTER- | Mishawaka | E220 Health Care | $378.9M | 14 |
| Elkhart General Hospital Inc | Elkhart | E220 Health Care | $365.6M | 18 |
| St Mary Medical Center Inc | Hobart | E220 Health Care | $358.4M | 9 |
| Butler University | Indianapolis | B430 Education | $320.7M | 9 |
| COMMUNITY HOSPITAL SOUTH INC | Indianapolis | E20 Health Care | $314.7M | 14 |
| EVERWISE CREDIT UNION | South Bend | — | $286.5M | 19 |
| CHURCH WORLD SERVICE INC | Elkhart | Q330 International, Foreign Affairs & National Security | $283.8M | 6 |
| RAMTELL INC | Tell City | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $273.8M | 5 |
| Goshen Hospital Association Inc | Goshen | E220 Health Care | $272.8M | 16 |
| COMMUNITY HOSPITAL OF ANDERSON AND | Anderson | E220 Health Care | $233.2M | 14 |
| Trine University | Angola | B420 Education | $232.8M | 10 |
| INDIANA WESLEYAN UNIVERSITY | Marion | B42Z Education | $226M | 11 |
| COMMUNITY HOWARD REGIONAL | Kokomo | Z99Z Unknown | $224.4M | 11 |
| MARION GENERAL HOSPITAL INC | Marion | E220 Health Care | $219.1M | 14 |
| DePauw University | Greencastle | B420 Education | $215.8M | 17 |
| Beacon Health System Inc | South Bend | E12 Health Care | $210.8M | 22 |
| Indiana University Health Plans NFP Inc | Indianapolis | E80 Health Care | $201M | 10 |
| ALVERNO PROVENA HOSPITAL LABORATORIES | Hammond | E20 Health Care | $199.1M | 9 |
| University of Indianapolis | Indianapolis | B430 Education | $192.8M | 8 |
