| ASHEVILLE HUMANE SOCIETY INC | Asheville | D200 Animal-Related | $5.8M | 1 |
| NEW HANOVER REGIONAL MEDICAL CENTER FOUNDATION INC | Winston Salem | E12 Health Care | $5.7M | 6 |
| Bridge to Turkiye | Chapel Hill | M20 Public Safety, Disaster Preparedness & Relief | $5.7M | 0 |
| Forum of Incident Response and Security Teams Inc | Cary | B90 Education | $5.7M | 3 |
| Reaching All Minds | Durham | B29 Education | $5.7M | 0 |
| H SMITH RICHARDSON CHARITABLE TRUST | Greensboro | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.7M | 0 |
| FIGURE EIGHT ISLAND YACHT CLUB INC | Wilmington | — | $5.7M | 3 |
| CENTER FOR CREDENTIALING AND EDUCATION | Greensboro | — | $5.7M | 2 |
| Communities in Schools of Cape Fear Inc | Wilmington | P20 Human Services | $5.7M | 1 |
| Spay Neuter Charlotte | Charlotte | D20 Animal-Related | $5.7M | 3 |
| CARENET INC | Winston Salem | J21Z Employment | $5.7M | 6 |
| INTERNATIONAL BROTHERHOOD OF ELECTRICAL WORKERS LU 379 | Charlotte | — | $5.7M | 15 |
| JACARANDA HEALTH | Durham | E40 Health Care | $5.7M | 3 |
| GUY C LEE BENEFIT PLAN TR | Smithfield | — | $5.7M | 0 |
| Classical Academies CFA Inc | Lake Lure | B29 Education | $5.7M | 1 |
| NORTH CAROLINA STATE UNIVERSITY ALUMNI ASSOCIATION INC | Raleigh | — | $5.7M | 5 |
| NORTH CAROLINA BUSINESS COMMITTEE FOR EDUCATION INC | Raleigh | — | $5.7M | 0 |
| VOICES TOGETHER INC | Chapel Hill | O50 Youth Development | $5.7M | 5 |
| North Carolina Health Care Facilities Association Inc | Raleigh | — | $5.7M | 3 |
| ACE ACADEMY | Harrisburg | B29 Education | $5.6M | 1 |
| AMBASSADOR CHRISTIAN SCHOOL INC | Huntersville | B25 Education | $5.6M | 2 |
| ASHE SERVICES FOR AGING INC | West Jefferson | P440 Human Services | $5.6M | 2 |
| New River Young Mens Christian Association Onslow Inc | Jacksonville | P27 Human Services | $5.6M | 2 |
| FAMILY CENTERED TREATMENT FOUNDATION INC | Charlotte | E42 Health Care | $5.6M | 1 |
| Carolina Foothills Foundation | Forest City | P74Z Human Services | $5.6M | 3 |
| RANDOLPH COMMUNITY SERVICES INC | Randleman | — | $5.6M | 0 |
| HEALTHCARE FOUNDATION OF WILSON | Wilson | E220 Health Care | $5.6M | 2 |
| FORSYTH MEDICAL CENTER FOUNDATION | Winston Salem | E112 Health Care | $5.6M | 8 |
| THE JOHN CROSLAND SCHOOL | Charlotte | — | $5.6M | 2 |
| NORTH SIDE FIRE & RESCUE INC | Clayton | F99 Mental Health & Crisis Intervention | $5.6M | 2 |
| The North Carolina Arboretum Society | Asheville | C410 Environment | $5.6M | 0 |
| SALEM BAPTIST CHRISTIAN SCHOOL | Winston Salem | B20 Education | $5.6M | 2 |
| VETERANS BRIDGE HOME INC | Charlotte | — | $5.6M | 7 |
| THE KATIE BLESSING FOUNDATION | Charlotte | E32 Health Care | $5.6M | 1 |
| NORTH RALEIGH MINISTRIES INC | Raleigh | X20 Religion-Related | $5.6M | 1 |
| EASTERN CAROLINA HUMAN SERVICES AGENCY INC | Jacksonville | P20 Human Services | $5.6M | 1 |
| YMCA BLUE RIDGE ASSEMBLY INC | Black Mountain | P270 Human Services | $5.5M | 2 |
| LONNIE & CAROL POOLE FAMILY FOUNDATION | Raleigh | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.5M | 0 |
| NAZARETH CHILDRENS HOME INC | Rockwell | P70Z Human Services | $5.5M | 3 |
| FEED THE HUNGER INC | Greensboro | — | $5.5M | 4 |
| AUTISM SERVICES OF MECKLENBURG COUN | Charlotte | G84Z Diseases, Disorders & Medical Disciplines | $5.5M | 1 |
| SOAR Inc | Balsam | C60Z Environment | $5.5M | 4 |
| OUR COMMUNITY HOSPITAL INC | Scotland Neck | — | $5.5M | 5 |
| REMNANT OF ISRAEL | Charlotte | — | $5.5M | 1 |
| THE ARTS COUNCIL INC | Winstonsalem | — | $5.5M | 2 |
| BOYS & GIRLS CLUBS OF GREATER HIGH POINT INC | High Point | O23 Youth Development | $5.5M | 1 |
| VETERAN GOLFERS ASSOCIATION | Pinehurst | — | $5.5M | 1 |
| ONSLOW COMMUNITY OUTREACH INC | Jacksonville | — | $5.5M | 1 |
| ASIA HARVEST INC | Winston Salem | Q12 International, Foreign Affairs & National Security | $5.5M | 0 |
| FEEDNC | Mooresville | K34Z Food, Agriculture & Nutrition | $5.5M | 1 |
