| Upstate Senior Living Inc | Greenville | P75 Human Services | $26.5M | 8 |
| REGENESIS HEALTH CARE INC | Spartanburg | E30 Health Care | $26.2M | 10 |
| Allen University | Columbia | B43Z Education | $26.1M | 8 |
| SPARTANBURG METHODIST COLLEGE | Spartanburg | B410 Education | $25.5M | 9 |
| HAMMOND SCHOOL | Columbia | B24Z Education | $25.2M | 6 |
| WESLEY COMMONS | Greenwood | P750 Human Services | $24.9M | 6 |
| LEGACY EARLY COLLEGE | Greenville | B29 Education | $24.8M | 5 |
| Leroy Springs & Company Inc | Fort Mill | N300 Recreation & Sports | $24.7M | 5 |
| Kiawah Island Community Association Inc | Kiawah Island | L50 Housing & Shelter | $24.7M | 8 |
| Insurance Institute for Business & Home | Richburg | M40 Public Safety, Disaster Preparedness & Relief | $24.2M | 10 |
| MIRACLE HILL MINISTRIES INC | Greenville | P200 Human Services | $24.2M | 4 |
| UPPER PALMETTO YMCA INC | Rock Hill | P27Z Human Services | $23.2M | 5 |
| Self Regional Healthcare Partners | Greenwood | E20 Health Care | $22.9M | 2 |
| SOUTHSIDE CHRISTIAN SCHOOL | Simpsonville | B25 Education | $22.6M | 6 |
| GREENVILLE HOUSING FUND | Greenville | L20 Housing & Shelter | $22.5M | 1 |
| FETTER HEALTH CARE NETWORK INC | Charleston | — | $22.5M | 9 |
| KERSHAWHEALTH | Camden | E220 Health Care | $22.2M | 11 |
| COMMUNITY SERVICES ASSOCIATES INC | Hilton Head Island | L50 Housing & Shelter | $22.1M | 7 |
| BERKELEY CHARTER EDUCATION ASSOCIATION I | Goose Creek | B29 Education | $22.1M | 0 |
| SCAGO EDUCATIONAL FACILITIES CORP | Easley | B112 Education | $22M | 2 |
| Greenville Country Club | Greenville | — | $21.9M | 7 |
| HEALTH CARE PARTNERS OF SOUTH CAROLINA INC | Conway | E320 Health Care | $21.8M | 9 |
| TRI-DEVELOPMENT CENTER OF AIKEN | Aiken | — | $21.3M | 3 |
| RURAL HEALTH SERVICES INC | Aiken | — | $21.3M | 13 |
| CHILDREN'S TRUST OF SOUTH CAROLINA | Columbia | P34J Human Services | $20.8M | 4 |
| South Carolina Aquarium | Charleston | D500 Animal-Related | $20.3M | 11 |
| CARETEAM PLUS INC | Conway | E80 Health Care | $20M | 6 |
| NATIONAL ASSOCIATION OF COMPETITIVE | Mt Pleasant | O50 Youth Development | $20M | 3 |
| United States Endowment for Forestry | Greenville | C34 Environment | $19.5M | 10 |
| YORK PREPARATORY ACADEMY INC | Rock Hill | B29 Education | $19.5M | 5 |
| FAMILY HEALTH CENTERS INC | Orangeburg | — | $19.4M | 10 |
| SALUDA NURSING CENTER | Saluda | — | $19.3M | 1 |
| PROJECT HOPE FOUNDATION INC | Greenville | P820 Human Services | $19.2M | 2 |
| ORANGE GROVE CHARTER SCHOOL | Charleston | B29 Education | $19M | 1 |
| HERITAGE CLASSIC FOUNDATION | Hilton Head Island | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $19M | 5 |
| EPWORTH CHILDREN'S HOME | Columbia | P70 Human Services | $18.9M | 3 |
| PALMETTO GOODWILL SERVICES | North Charleston | J320 Employment | $18.8M | 9 |
| PEE DEE COMMUNITY ACTION | Florence | — | $18.8M | 0 |
| Connie Maxwell Children's Ministries | Greenwood | P730 Human Services | $18.8M | 6 |
| YORK COUNTY BOARD OF DISABILITIES | York | — | $18.7M | 2 |
| CAMPBELL YOUNG LEADERS | Greenville | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $18.6M | 1 |
| MORRIS COLLEGE | Sumter | B42Z Education | $18.2M | 2 |
| ST LUKES FREE MEDICAL CLINIC OF | Spartanburg | E30Z Health Care | $17.9M | 2 |
| WATERFRONT EMPLOYERS - ILA WELFARE PL | Charleston | — | $17.6M | 3 |
| ST JOHN'S WATER COMPANY INC | Johns Island | — | $17.5M | 0 |
| ROAD2HIRE | Fort Mill | B30 Education | $17.2M | 0 |
| SOUTH CAROLINA CHRISTIAN FOUNDATION | Spartanburg | X20 Religion-Related | $17M | 1 |
| HIGH POINT ACADEMY INC | Spartanburg | B29 Education | $16.9M | 1 |
| BLUE RIDGE RURAL WATER CO INC | Greer | — | $16.8M | 1 |
| EASTERN CAROLINA HOMELESSNESS ORG INC | Myrtle Beach | L41 Housing & Shelter | $16.8M | 2 |
