| COASTAL COMMUNITY FOUNDATION OF SOUTH CAROLINA INC | N Charleston | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $46.3M | 8 |
| SOUTH CAROLINA EPISCOPAL HOME at Still Hopes | W Columbia | E91Z Health Care | $45.8M | 10 |
| SOUTHEASTERN FREIGHT LINES HEALTH INSURANCE TRUST | Columbia | — | $45.7M | 0 |
| CHARLESTON EDUCATIONAL EXCELLENCE FINANCING CORPORATION | Charleston | N40 Recreation & Sports | $45M | 1 |
| SOUTH CAROLINA LEARNS | Greenville | B99 Education | $45M | 2 |
| UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE EDUCATIONAL TRUST | Columbia | B54Z Education | $44.2M | 19 |
| CHRIST CHURCH EPISCOPAL SCHOOL | Greenville | B20 Education | $44.1M | 9 |
| CONVERSE UNIVERSITY | Spartanburg | B430 Education | $41.5M | 7 |
| WATER MISSIONS INTERNATIONAL | North Charleston | Q30 International, Foreign Affairs & National Security | $41.1M | 8 |
| NATIONAL COUNCIL OF EXAMINERS FOR ENGINEERING AND SURVEYING | Greenville | U42D Science & Technology | $40.8M | 9 |
| BABCOCK CENTER INC | West Columbia | P820 Human Services | $40.7M | 3 |
| CENTRAL CAROLINA COMMUNITY FOUNDATION | Columbia | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $39.8M | 4 |
| CONTAINER ROYALTY SUPPLEMENTAL CASH BENEFIT PLAN | Charleston | Z99 Unknown | $39.2M | 3 |
| DARLA MOORE AND RICHARD RAINWATER FOUNDATION | Lake City | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $38.6M | 1 |
| Voorhees College | Denmark | B42Z Education | $38.4M | 0 |
| CAROLINA HEALTH CENTERS INC | Greenwood | E32Z Health Care | $38.3M | 11 |
| THE CITADEL FOUNDATION | Charleston | B110 Education | $37.9M | 7 |
| COMMUNITY FOUNDATION OF GREENVILLE INC | Greenville | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $37.6M | 2 |
| HAMPTON REGIONAL MEDICAL CENTER | Varnville | E220 Health Care | $36.9M | 6 |
| St Francis Physician Services Inc | Greenville | E32 Health Care | $36.9M | 18 |
| LIMESTONE CHARTER ASSOCIATION | Columbia | — | $36.8M | 5 |
| THE CHARLES LEA CENTER INC | Spartanburg | E50Z Health Care | $36.6M | 5 |
| LEXMED INC | Lexington | E91 Health Care | $36.5M | 10 |
| RADIO TRAINING NETWORK INC | Greenville | X800 Religion-Related | $36.3M | 11 |
| WEST CAROLINA RURAL TELEPHONE COOPERATIVE INC | Abbeville | — | $36.1M | 15 |
| Cannon Memorial Hospital | Pickens | E22 Health Care | $36M | 10 |
| Columbia College | Columbia | B420 Education | $35.8M | 11 |
| SUNBELT HUMAN ADVANCEMENT RESOURCES INC | Greenville | B210 Education | $35.7M | 4 |
| The Inspirational Network Inc | Indian Land | X82 Religion-Related | $35.3M | 27 |
| SANDHILLS MEDICAL FOUNDATION INC | McBee | E39Z Health Care | $35.1M | 10 |
| RICHLAND COUNTY PUBLIC LIBRARY | Columbia | B700 Education | $34.9M | 7 |
| LITTLE RIVER ELECTRIC COOPERATIVE INC | Abbeville | — | $34.2M | 16 |
| TANDEM HEALTH SC | Sumter | E20 Health Care | $33.2M | 9 |
| GLEAMNS HUMAN RESOURCES COMMISSION INC | Greenwood | B22Z Education | $32.7M | 3 |
| CHARLESTON AREA CONVENTION & VISITORS BUREAU | Charleston | S20 Community Improvement & Capacity Building | $32.3M | 7 |
| GREENWOOD GENETIC CENTER INC | Greenwood | H200 Medical Research | $31.7M | 12 |
| NEW HORIZON FAMILY HEALTH SERVICES INC | Greenville | E30Z Health Care | $31.3M | 10 |
| SPARTANBURG METHODIST COLLEGE | Spartanburg | B410 Education | $31.2M | 9 |
| REGENESIS HEALTH CARE INC | Spartanburg | E30 Health Care | $31.2M | 12 |
| BEAUFORT-JASPER-HAMPTON COMPREHENSIVE HEALTH SERVICES INC | Okatie | E30Z Health Care | $30.7M | 9 |
| COASTAL ELECTRIC COOPERATIVE INC | Walterboro | — | $30.6M | 16 |
| GREENVILLE RENEWABLE ENERGY EDUCATION NETWORK | Greenville | B20 Education | $30.6M | 0 |
| Wateree Community Actions Inc | Columbia | P50 Human Services | $30.4M | 0 |
| FORT MILL PUBLIC FACILITIES CORPORATION | Fort Mill | W20 Public & Societal Benefit | $30.4M | 0 |
| Movement Resources | Fort Mill | L99 Housing & Shelter | $30.2M | 0 |
| CLC ADMINISTRATIVE SERVICES INC | Spartanburg | — | $29.9M | 0 |
| SCBMA | Columbia | P750 Human Services | $29.9M | 7 |
| YMCA OF GREENVILLE | Greenville | P270 Human Services | $29.8M | 8 |
| SOUTH CAROLINA LIFE AND ACCIDENT AND HEALTH INSURANCE GUARANTY ASSOCIATION | Columbia | — | $29.8M | 0 |
| MUSC HEALTH PARTNERS | Charleston | E11 Health Care | $29.8M | 8 |
