| MEDICAL FOUNDATION INC | Meridian | E320 Health Care | $41.4M | 10 |
| THE BULLDOG CLUB INC | Mississippi State | — | $41.3M | 9 |
| SOUTHERN MS PLANNING & | Gulfport | — | $39.1M | 3 |
| DELTA HEALTH ALLIANCE INC | Stoneville | H12 Medical Research | $37.2M | 11 |
| Central Mississippi Civic Improvement Association Inc | Jackson | E320 Health Care | $37.1M | 23 |
| FRIENDS OF CHILDREN OF MISSISSIPPI | Flowood | B210 Education | $35.4M | 2 |
| TWIN COUNTY ELECTRIC POWER | Hollandale | — | $34.3M | 17 |
| WINSTON COUNTY MEDICAL FOUNDATION | Louisville | — | $33.7M | 5 |
| RUSH HEALTH SYSTEMS INC | Meridian | — | $33.5M | 10 |
| Pontotoc Health Services Inc | Tupelo | E21Z Health Care | $33.2M | 9 |
| Reformed Theological Seminary | Jackson | B500 Education | $33M | 12 |
| SOUTHEAST MISSISSIPPI RURAL HEALTH INITIATIVE INC | Hattiesburg | E39Z Health Care | $33M | 9 |
| ECM GROUP HEALTH TRUST | Ridgeland | Y43 Mutual & Membership Benefit | $32.4M | 0 |
| LAIRD HOSPITAL INC | Union | E20 Health Care | $32.1M | 9 |
| MONROE COUNTY ELECTRIC POWER ASSOCI | Amory | — | $31.7M | 11 |
| RePublic Schools Jackson Inc | Jackson | B20 Education | $31M | 1 |
| THREE RIVERS PLANNING & DEVELOPMENT | Pontotoc | S200 Community Improvement & Capacity Building | $30.3M | 5 |
| Tougaloo College | Tougaloo | B42Z Education | $30.2M | 8 |
| COASTAL FAMILY HEALTH CENTER INC | Biloxi | E30Z Health Care | $29.1M | 1 |
| MISSISSIPPI CHILDREN'S HOME SOCIETY | Jackson | — | $27.4M | 11 |
| BAPTIST MEMORIAL HOSPITAL-BOONEVILLE | Booneville | E220 Health Care | $26.8M | 12 |
| UNIVERSITY OF SOUTHERN MISSISSIPPI | Hattiesburg | B110 Education | $26.8M | 3 |
| CREATE FOUNDATION | Tupelo | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $26.2M | 3 |
| ST CATHERINE'S VILLAGE INC | Jackson | E90 Health Care | $25.9M | 9 |
| Webster Health Services Inc | Tupelo | E220 Health Care | $25.6M | 9 |
| MISSISSIPPI ORGAN RECOVERY AGENCY | Flowood | E65Z Health Care | $25.3M | 15 |
| Family Health Care Clinic Inc | Jackson | E21Z Health Care | $24.9M | 15 |
| MISSISSIPPI BANKERS VOLUNTARY | Ridgeland | — | $24.6M | 0 |
| AAA AMBULANCE SERVICE INC | Hattiesburg | M23 Public Safety, Disaster Preparedness & Relief | $23.9M | 1 |
| GLOBAL OUTREACH INTERNATIONAL INC | Tupelo | Q33 International, Foreign Affairs & National Security | $23M | 3 |
| KEMPER CAH INC | Meridian | E20 Health Care | $22.9M | 9 |
| COAHOMA ELECTRIC POWER ASSN | Lyon | — | $22.8M | 12 |
| JACKSON ACADEMY INC | Jackson | B24Z Education | $22.8M | 1 |
| CARES CENTER INC | Jackson | B28Z Education | $22.8M | 11 |
| CHICKASAW INKANA FOUNDATION | Tupelo | A80 Arts, Culture & Humanities | $22.1M | 0 |
| SIMPSON COMMUNITY HEALTHCARE INC | Mendenhall | E22 Health Care | $21.8M | 10 |
| NORTH MISSISSIPPI COMMISSION ON MENTAL ILLNESS & MENTAL RETARDATIO | Oxford | F80Z Mental Health & Crisis Intervention | $21.6M | 7 |
| BLUE MOUNTAIN CHRISTIAN UNIVERSITY | Blue Mountain | B420 Education | $21.6M | 4 |
| RUSH HOSPITAL - BUTLER INC | Meridian | E22 Health Care | $21.6M | 6 |
| ALCORN COUNTY ELECTRIC POWER ASSOCI | Corinth | — | $21.3M | 10 |
| BAPTIST MEDICAL CENTER - YAZOO INC | Yazoo City | E22 Health Care | $21M | 13 |
| BAPTIST MEDICAL CENTER - LEAKE INC | Jackson | E22 Health Care | $20.9M | 16 |
| MADISON-RIDGELAND ACADEMY | Madison | B24Z Education | $20.7M | 3 |
| MISSISSIPPI BLOOD SERVICES INC | Flowood | E61Z Health Care | $20.4M | 7 |
| TRUSTMARK CORP & SUBS MEDICAL BENEFITS PLAN | Jackson | — | $20.2M | 0 |
| MISSISSIPPI BAPTIST HEALTH SYSTEMS INC | Jackson | E210 Health Care | $19.9M | 17 |
| BOLIVAR COUNTY COMMUNITY ACTION | Cleveland | P20Z Human Services | $19.7M | 1 |
| DELTA HEALTH CENTER INC | Mound Bayou | — | $19.1M | 2 |
| GACARMICHAEL FAMILY HEALTH CENTER INC | Canton | E320 Health Care | $19.1M | 0 |
| HOPE ENTERPRISE CORPORATION | Jackson | S20 Community Improvement & Capacity Building | $19M | 7 |
