| CONNEXUS HUMAN SERVICE NETWORK | Johnstown | P44 Human Services | $6M | 0 |
| 1889 - CHS FOUNDATION INC | Johnstown | X00Z Religion-Related | $6M | 2 |
| WESTERN PENNSYLVANIA OPERATING ENGI | New Alexandria | — | $6M | 3 |
| VINCENTIAN DE MARILLAC | Pittsburgh | E91Z Health Care | $6M | 3 |
| AMERICAN CABLE ASSOCIATION INC | Beaver | — | $6M | 5 |
| FRIENDS BOARDING HOME OF WESTERN | Kennett Square | — | $6M | 1 |
| PCA Care Connections | Philadelphia | E21 Health Care | $5.9M | 1 |
| THE CHANTICLEER FOUNDATION | Wayne | — | $5.9M | 1 |
| INSURANCE INFORMATION INSTITUTE INC | Malvern | — | $5.9M | 4 |
| POTENTIAL INC | Newtown | P20 Human Services | $5.9M | 1 |
| Unite for HER | Malvern | G193 Diseases, Disorders & Medical Disciplines | $5.9M | 6 |
| ARTISANS ORDER OF MUTUAL | Penndel | — | $5.9M | 1 |
| THE THERAPEUTIC CENTER AT FOX CHASE AKA | Philadelphia | F22Z Mental Health & Crisis Intervention | $5.9M | 2 |
| THE UNION LEAGUE LEGACY FOUNDATION | Philadelphia | O11 Youth Development | $5.9M | 3 |
| ST DAVIDS GOLF CLUB | Wayne | — | $5.9M | 4 |
| Granite State Elec Co PBT For NMP | Pittsburgh | Y43 Mutual & Membership Benefit | $5.9M | 1 |
| Erie Zoological Society | Erie | D500 Animal-Related | $5.9M | 1 |
| PENNSYLVANIA COMMUNITY REAL ESTATE CORP | Philadelphia | L80 Housing & Shelter | $5.9M | 1 |
| James T and Rose M Perryman Family Foundation | Houston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.9M | 0 |
| ALLONE FOUNDATION | Wilkesbarre | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.9M | 1 |
| STEAMFITTERS LOCAL UNION NO 449 JOINT | Pittsburgh | J22 Employment | $5.9M | 0 |
| The Elwyn Foundation | Elwyn | P11 Human Services | $5.9M | 5 |
| WHITFORD COUNTRY CLUB | Exton | — | $5.8M | 4 |
| Tidioute Community Charter School | Tidioute | B29 Education | $5.8M | 1 |
| LITITZ COMMUNITY CENTER INC | Lititz | P33Z Human Services | $5.8M | 1 |
| BALA PRESBYTERIAN HOME FOUNDATION | Lafayette Hill | P110 Human Services | $5.8M | 9 |
| CRAWFORD HERITAGE COMMUNITY FOUNDATION | Meadville | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $5.8M | 1 |
| YOUNG MENS CHRISTIAN ASSOCIATION OF MONROE COUNTY | Stroudsburg | — | $5.8M | 1 |
| Yeshiva Gedolah of Elkins Park | Elkins Park | X30 Religion-Related | $5.8M | 1 |
| BNY MELLON FOUNDATION OF SOUTHWESTERN PA | Pittsburgh | — | $5.8M | 0 |
| THE PITTSBURGH GOLF CLUB | Pittsburgh | — | $5.8M | 4 |
| Catholic Community Services | Philadelphia | — | $5.8M | 3 |
| BREASTCANCERORG | Ardmore | H01 Medical Research | $5.8M | 10 |
| CHARCOT-MARIE-TOOTH ASSOCIATION | Glenolden | G8XZ Diseases, Disorders & Medical Disciplines | $5.8M | 5 |
| PHILADELPHIA ANIMAL WELFARE SOCIETY | Philadelphia | D20 Animal-Related | $5.8M | 1 |
| MIDDLE ATLANTIC-GREAT LAKES ORGANIZED | Newtown | M99 Public Safety, Disaster Preparedness & Relief | $5.8M | 5 |
| AMERICAN BOARD OF OPHTHALMOLOGY | Doylestown | — | $5.8M | 22 |
| Christian Counseling & Educational | Glenside | P46Z Human Services | $5.7M | 3 |
| CHILDREN'S CHOICE INC | Chester | P320 Human Services | $5.7M | 5 |
| TEST MONITORING CENTER | Freeport | W90 Public & Societal Benefit | $5.7M | 7 |
| SOROPTIMIST INTERNATIONAL | Philadelphia | I70 Crime & Legal-Related | $5.7M | 5 |
| EASTON ARTS ACADEMY ELEMENTARY | Easton | B20 Education | $5.7M | 2 |
| Miami International University Of Art & DesignLLC | Carnegie | — | $5.7M | 3 |
| BERWYN FIRE COMPANY | Berwyn | M24Z Public Safety, Disaster Preparedness & Relief | $5.7M | 6 |
| UPMC Center for High-Value Healthcare | Pittsburgh | E32 Health Care | $5.7M | 12 |
| LUTHERAN SOCIAL MISSION SOCIETY | Philadelphia | — | $5.7M | 1 |
| THE CREFELD SCHOOL | Philadelphia | — | $5.7M | 1 |
| City of Bridges Housing Development | Pittsburgh | L11 Housing & Shelter | $5.7M | 0 |
| GERMANTOWN CRICKET CLUB | Philadelphia | — | $5.7M | 2 |
| POISE FOUNDATION | Pittsburgh | T300 Philanthropy, Voluntarism & Grantmaking Foundations | $5.7M | 2 |
