| UPMC GROUP | Pittsburgh | — | $22.6B | 275 |
| NATIONAL PHILANTHROPIC TRUST | Jenkintown | T500 Philanthropy, Voluntarism & Grantmaking Foundations | $10B | 18 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | Philadelphia | B430 Education | $9.9B | 47 |
| Highmark Health Group | Pittsburgh | — | $5.6B | 81 |
| VANGUARD CHARITABLE ENDOWMENT PROGRAM | Southeastern | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $4.6B | 9 |
| THE CHILDREN'S HOSPITAL OF PHILADELPHIA | Philadelphia | E240 Health Care | $3.4B | 15 |
| GEISINGER HEALTH PLAN | Danville | — | $3.2B | 18 |
| LEHIGH VALLEY HOSPITAL | Allentown | E220 Health Care | $3.2B | 18 |
| UNIVERSITY OF PITTSBURGH | Pittsburgh | B99 Education | $3.1B | 17 |
| THE MILTON S HERSHEY MEDICAL CENTER | Hershey | E20 Health Care | $2.6B | 18 |
| THOMAS JEFFERSON UNIVERSITY HOSPITALS INC | Philadelphia | E200 Health Care | $2.6B | 13 |
| HEALTH PARTNERS PLANS INC | Philadelphia | — | $2.5B | 16 |
| Temple University Hospital Inc | Philadelphia | E22 Health Care | $2.1B | 23 |
| GEISINGER CLINIC | Danville | E30 Health Care | $1.9B | 29 |
| CARNEGIE MELLON UNIVERSITY | Pittsburgh | — | $1.9B | 26 |
| GEISINGER MEDICAL CENTER | Danville | E220 Health Care | $1.9B | 30 |
| THOMAS JEFFERSON UNIVERSITY | Philadelphia | B500 Education | $1.7B | 21 |
| Main Line Hospitals Inc | Newtown Square | E220 Health Care | $1.6B | 41 |
| YORK HOSPITAL | York | E220 Health Care | $1.6B | 16 |
| ALBERT EINSTEIN HEALTHCARE NETWORK GROUP | Philadelphia | — | $1.6B | 32 |
| Temple University - Of The Commonwealth System of Higher Education | Philadelphia | B430 Education | $1.5B | 31 |
| LANCASTER GENERAL HOSPITAL | Lancaster | E220 Health Care | $1.5B | 39 |
| UPMC PINNACLE HOSPITALS | Harrisburg | E220 Health Care | $1.5B | 17 |
| ST LUKE'S HOSPITAL OF BETHLEHEM PA | Allentown | E220 Health Care | $1.4B | 1 |
| DREXEL UNIVERSITY | Philadelphia | B43 Education | $1.4B | 22 |
| READING HOSPITAL | Reading | E220 Health Care | $1.4B | 23 |
| PENNSYLVANIA EMPLOYEES BENEFIT TRUST FUND | Harrisburg | — | $1.3B | 9 |
| COMMUNITY BEHAVIORAL HEALTH | Philadelphia | F300 Mental Health & Crisis Intervention | $1.2B | 21 |
| PRESBYTERIAN MEDICAL CENTER OF THE | Philadelphia | E220 Health Care | $1.2B | 15 |
| NATIONAL ELEVATOR INDUSTRY HEALTH | Newtown Square | — | $1.1B | 6 |
| GlaxoSmithKline Patient Access | Philadelphia | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $1.1B | 0 |
| ABINGTON MEMORIAL HOSPITAL | Philadelphia | E220 Health Care | $912M | 11 |
| DELTA DENTAL OF PENNSYLVANIA | Camp Hill | Y20 Mutual & Membership Benefit | $907.7M | 25 |
| GEISINGER WYOMING VALLEY MEDICAL | Danville | E220 Health Care | $905.8M | 21 |
| GBU Financial Life | Pittsburgh | — | $903.7M | 17 |
| STEELWORKERS HEALTH & WELFARE FUND | Pittsburgh | — | $885M | 1 |
| VILLANOVA UNIVERSITY | Villanova | B430 Education | $876.6M | 30 |
| WELLSPAN MEDICAL GROUP | York | E31Z Health Care | $858.7M | 22 |
| PENNSYLVANIA HOSPITAL OF THE | Philadelphia | E220 Health Care | $816.6M | 14 |
| MILTON HERSHEY SCHOOL AND SCHOOL TRUST | Hershey | B200 Education | $814M | 29 |
| LEHIGH VALLEY PHYSICIAN GROUP | Allentown | E31Z Health Care | $807.9M | 41 |
| GEISINGER SYSTEM SERVICES | Danville | E210 Health Care | $801.3M | 23 |
| DELTA DENTAL OF NEW YORK INC | Camp Hill | Y20 Mutual & Membership Benefit | $789.7M | 23 |
| KENNEDY UNIVERSITY HOSPITAL INC | Philadelphia | E220 Health Care | $779.7M | 10 |
| ST LUKE'S PHYSICIAN GROUP INC | Allentown | — | $747.5M | 6 |
| LEHIGH UNIVERSITY | Bethlehem | B430 Education | $695.4M | 15 |
| JEFFERSON HEALTH - NORTHEAST | Philadelphia | E220 Health Care | $690.3M | 17 |
| UNITED STEEL PAPER AND FORESTRY | Pittsburgh | — | $604.1M | 27 |
| PENN STATE HEALTH | Hershey | E19 Health Care | $601.2M | 23 |
| WELLSPAN HEALTH | York | E21Z Health Care | $593.2M | 22 |
