| THE CLEVELAND CLINIC FOUNDATION | Independence | E030 Health Care | $15.6B | 151 |
| BATTELLE MEMORIAL INSTITUTE | Columbus | U200 Science & Technology | $13.3B | 32 |
| THE CLEVELAND CLINIC FOUNDATION | Independence | E210 Health Care | $9B | 27 |
| Bon Secours Mercy Health Inc | Cincinnati | E210 Health Care | $8.7B | 34 |
| CareSource Ohio Inc | Dayton | E31Z Health Care | $8.5B | 7 |
| UNIVERSITY HOSPITALS HEALTH SYSTEM INC | Shaker Heights | E21Z Health Care | $5.3B | 68 |
| OhioHealth Corporation | Columbus | E220 Health Care | $4.5B | 24 |
| Nationwide Childrens Hospital Group Return | Columbus | — | $3.9B | 39 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | Cincinnati | E240 Health Care | $3.1B | 21 |
| CareSource | Dayton | E110 Health Care | $2.5B | 24 |
| UC HEALTHCARE SYSTEM | Cincinnati | E99 Health Care | $2.3B | 19 |
| Bon Secours - Richmond Health System Inc | Cincinnati | E21 Health Care | $2B | 18 |
| OhioHealth Corporation Group Return | Columbus | E210 Health Care | $1.9B | 26 |
| CareSource Georgia Co | Dayton | E31 Health Care | $1.6B | 7 |
| THE TOLEDO HOSPITAL | Toledo | E220 Health Care | $1.6B | 17 |
| MIAMI VALLEY HOSPITAL | Dayton | E220 Health Care | $1.6B | 30 |
| Summa Health Group Return | Akron | — | $1.5B | 19 |
| CASE WESTERN RESERVE UNIVERSITY | Cleveland | B430 Education | $1.5B | 15 |
| CHILDREN'S HOSPITAL MEDICAL CENTER OF | Akron | E240 Health Care | $1.4B | 17 |
| MOUNT CARMEL HEALTH SYSTEM | Columbus | — | $1.4B | 17 |
| CareSource Indiana Inc | Dayton | E80 Health Care | $1.3B | 6 |
| AMERICAN ENDOWMENT FOUNDATION | Hudson | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $1.3B | 25 |
| The Christ Hospital | Cincinnati | E220 Health Care | $1.3B | 9 |
| KROGER CO HEALTH & WELFARE TRUST FOR | Cincinnati | — | $1.2B | 0 |
| Kettering Medical Center | Miamisburg | E220 Health Care | $1.1B | 21 |
| HCR MANORCARE INC | Toledo | E91 Health Care | $1B | 14 |
| AULTMAN HEALTH FOUNDATION GROUP RETURN | Canton | E21 Health Care | $1B | 31 |
| OHIO STATE UNIVERSITY PHYSICIANS INC | Columbus | B020 Education | $1B | 38 |
| UNIVERSITY HOSPITALS HEALTH SYSTEM INC | Shaker Heights | E210 Health Care | $990.1M | 20 |
| JACK JOSEPH & MORTON MANDEL FOUNDATION | Cleveland | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $929.7M | 2 |
| BUCKEYE POWER INC | Columbus | — | $915.5M | 19 |
| BETHESDA HOSPITAL INC | Cincinnati | E220 Health Care | $896.5M | 24 |
| THE GOOD SAMARITAN HOSPITAL OF | Cincinnati | E220 Health Care | $889.2M | 23 |
| University of Dayton | Dayton | B430 Education | $887.6M | 32 |
| DAYTON OSTEOPATHIC HOSPITAL | Miamisburg | E240 Health Care | $870.3M | 25 |
| GENESIS HEALTHCARE SYSTEM | Zanesville | E220 Health Care | $759.9M | 19 |
| CHRISTIAN HEALTHCARE MINISTRIES INC | Barberton | X20 Religion-Related | $754.7M | 16 |
| JOBSOHIO BEVERAGE SYSTEM | Columbus | S32 Community Improvement & Capacity Building | $732.5M | 3 |
| ADENA HEALTH SYSTEM | Chillicothe | E210 Health Care | $670M | 21 |
| JOBSOHIO | Columbus | J20 Employment | $667.3M | 19 |
| DAYTON CHILDREN'S HOSPITAL | Dayton | E240 Health Care | $651.3M | 9 |
| MOUNT CARMEL HEALTH PLAN INC | Columbus | E310 Health Care | $583.7M | 13 |
| SOUTHERN OHIO CHAMBER ALLIANCE | Cincinnati | Y43 Mutual & Membership Benefit | $546.2M | 0 |
| SOUTHERN OHIO MEDICAL CENTER | Portsmouth | E20Z Health Care | $520M | 15 |
| MARIETTA MEMORIAL HOSPITAL | Marietta | E220 Health Care | $518.2M | 10 |
| WRIGHT-PATT CREDIT UNION INC | Beavercreek | — | $518M | 36 |
| Nationwide Ins Co & Aff EE HealthCare Trust | Columbus | — | $501.4M | 0 |
| Oberlin College | Oberlin | B420 Education | $467.8M | 21 |
| SOUTHWEST GENERAL HEALTH CENTER | Middleburg Hts | E220 Health Care | $419.7M | 15 |
| BLANCHARD VALLEY REGIONAL HEALTH CENTER | Findlay | E220 Health Care | $413.6M | 9 |
