| KIPP FOUNDATION | San Francisco | B99 Education | $78.3M | 11 |
| SCHMIDT OCEAN INSTITUTE | Palo Alto | U21 Science & Technology | $78.3M | 1 |
| COUNCIL OF COMMUNITY CLINICS | San Diego | — | $78.3M | 11 |
| MADERA UNIFIED SCHOOL DISTRICT FINANCING | Madera | B112 Education | $78.2M | 5 |
| JEWISH FAMILY SERVICE OF SAN DIEGO | San Diego | P84Z Human Services | $78.1M | 7 |
| THE OLYMPIC CLUB | San Francisco | — | $77.8M | 12 |
| INTERNATIONAL UNION OF OPERATING ENGINEERS | Concord | — | $77.7M | 35 |
| INSTITUTE ON AGING | San Francisco | P750 Human Services | $77.6M | 8 |
| COMMUNITY INITIATIVES | Oakland | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $77.6M | 10 |
| ORTHOPAEDIC HOSPITAL | Los Angeles | E240 Health Care | $77.3M | 11 |
| CALIFORNIA ASSOCIATION OF FOOD BANKS | Oakland | K31 Food, Agriculture & Nutrition | $76.8M | 10 |
| Adventist Health Medical Ctr Tehachapi | Tehachapi | — | $76.8M | 23 |
| SAN FRANCISCO FIRE CREDIT UNION | San Francisco | — | $76.7M | 26 |
| WHITTIER COLLEGE | Whittier | B430 Education | $76.2M | 11 |
| KEYPOINT CREDIT UNION | San Jose | W61 Public & Societal Benefit | $75.9M | 22 |
| GOOD NEIGHBORS GLOBAL PARTNERSHIP | Tustin | Q33 International, Foreign Affairs & National Security | $75.7M | 1 |
| U A LOCAL 393 HEALTH & WELFARE TRUST | San Jose | — | $75.7M | 5 |
| GOODWILL OF THE SAN FRANCISCO BAY | San Francisco | J32Z Employment | $75.6M | 8 |
| LA JOLLA INSTITUTE FOR IMMUNOLOGY | La Jolla | — | $75.6M | 11 |
| Oaks Christian School | Westlake Village | B250 Education | $75.5M | 10 |
| THE CALTECH VEBA FOR JPL RETIREES | San Diego | Y43 Mutual & Membership Benefit | $75.5M | 1 |
| MULTIPLIER | San Francisco | C60 Environment | $75M | 7 |
| EFFECTIVE VENTURES FOUNDATION USA INC | San Francisco | B05 Education | $75M | 12 |
| THE CLASSICAL ACADEMY | Escondido | B24 Education | $74.8M | 11 |
| Barlow Respiratory Hospital | Los Angeles | E240 Health Care | $74.8M | 10 |
| KFH HOLDINGS INC | Oakland | E60 Health Care | $74.7M | 7 |
| WM KECK FOUNDATION | Los Angeles | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $74.7M | 11 |
| THE COLBURN SCHOOL | Los Angeles | A6E0 Arts, Culture & Humanities | $74.2M | 10 |
| CARP 46 NO CA COUNTIES CONF BOARD- | Oakland | — | $74M | 3 |
| NUEVA SCHOOL | Hillsborough | B240 Education | $74M | 8 |
| BRILLIANT CORNERS | San Francisco | B90 Education | $73.9M | 10 |
| PETALUMA HEALTH CENTER INC | Petaluma | E32 Health Care | $73.5M | 22 |
| ENTERTAINMENT INDUSTRY FOUNDATION | Los Angeles | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $72.9M | 9 |
| SAN DIEGO HUMANE SOCIETY & SPCA | San Diego | D200 Animal-Related | $72.9M | 8 |
| USVETS HOUSING CORPORATION | Los Angeles | W30 Public & Societal Benefit | $72.8M | 3 |
| THE DAVID GEFFEN FOUNDATION | Los Angeles | — | $72.8M | 1 |
| GUIDE DOGS FOR THE BLIND INC | San Rafael | P860 Human Services | $72.8M | 7 |
| California Teaching Fellows Foundation | Fresno | — | $72.7M | 14 |
| CAMARENA HEALTH | Madera | E320 Health Care | $72.7M | 7 |
| TURNING POINT COMMUNITY PROGRAMS | Rancho Cordova | P820 Human Services | $72.7M | 12 |
| THE WILLIAM JEFF AND JENNIFER GROSS | Laguna Beach | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $72.6M | 1 |
| SOUTHERN MONTEREY COUNTY MEMORIAL | King City | — | $72.4M | 13 |
| LA SIERRA UNIVERSITY | Riverside | B430 Education | $72.3M | 8 |
| JOB OPTIONS INC | San Diego | J30 Employment | $72.2M | 32 |
| INLAND SOUTHERN CALIFORNIA 211 | Ontario | T40Z Philanthropy, Voluntarism & Grantmaking Foundations | $72M | 2 |
| NATIONAL COMMUNITY RENAISSANCE | Rancho Cucamonga | L200 Housing & Shelter | $72M | 25 |
| SAN JOSE STATE UNIVERSITY | San Jose | B110 Education | $71.9M | 21 |
| RADY CHILDREN'S HOSPITAL FOUNDATION | San Diego | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $71.7M | 12 |
| UNITED STATES OLYMPIC AND PARALYMPIC | Los Angeles | N71 Recreation & Sports | $71.6M | 10 |
| LA Family Housing Corp | North Hollywood | — | $71.5M | 14 |
