| CSU FULLERTON AUXILIARY SERVICES | Fullerton | B11 Education | $56.4M | 12 |
| CRESCENT VIEW SOUTH INC | Valencia | B29 Education | $56.3M | 14 |
| Foundation for Grossmont and | El Cajon | B125 Education | $56.3M | 8 |
| Catholic Charities of Santa Clara County | San Jose | P20Z Human Services | $56.2M | 10 |
| WONDERFUL COLLEGE PREP ACADEMY | Delano | B29 Education | $56.2M | 7 |
| POLYTECHNIC SCHOOL | Pasadena | B200 Education | $56.1M | 7 |
| CITIZENS OF THE WORLD CHARTER SCHOOLS | Los Angeles | B29 Education | $56.1M | 8 |
| EDUCATION FOR CHANGE | Oakland | B29 Education | $56.1M | 7 |
| QUALITY DEVELOPMENT AND CONSTRUCTION | Irvine | L11 Housing & Shelter | $56M | 13 |
| ASSOCIATED STUDENTS UCLA | Los Angeles | B110 Education | $56M | 12 |
| Unlikely Collaborators Inc | West Hollywood | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $55.8M | 0 |
| TIGER WOODS CHARITY EVENT CORP | Irvine | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $55.5M | 7 |
| UNION STATION VENTURE CORPORATION NO P-5 | San Francisco | — | $55.5M | 0 |
| The McConnell Foundation | Redding | B82 Education | $55.5M | 7 |
| SOUTHERN CALIFORNIA UNIVERSITY OF HEALTH | Whittier | B500 Education | $55.4M | 12 |
| MIDPEN HOUSING CORPORATION | Foster City | L210 Housing & Shelter | $55.4M | 8 |
| CAL POLY HUMBOLDT SPONSORED | Arcata | B43I Education | $55.3M | 21 |
| The Illumination Foundation | Santa Ana | P85 Human Services | $55.3M | 4 |
| St Margaret of Scotland Episcopal School | San Juan Capistrano | — | $55M | 13 |
| ALL FOR KIDS ORGANIZATION | Los Angeles | P300 Human Services | $54.9M | 8 |
| CANINE COMPANIONS FOR INDEPENDENCE INC | Santa Rosa | P8XZ Human Services | $54.9M | 15 |
| VALLEY HEALTH TEAM INC | San Joaquin | E30Z Health Care | $54.9M | 7 |
| CREATIVE CENTER OF LOS ALTOS | Los Altos | B24Z Education | $54.8M | 11 |
| LIGHTHOUSE FOR THE BLIND | San Francisco | P860 Human Services | $54.8M | 13 |
| ROOM TO BREATHE PROJECT | San Francisco | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $54.8M | 0 |
| Los Angeles Tourism & Convention Board | Los Angeles | — | $54.7M | 10 |
| MERCY HOUSE LIVING CENTERS | Santa Ana | L410 Housing & Shelter | $54.6M | 6 |
| CLIMATE BREAKTHROUGH INC | Berkeley | P20 Human Services | $54.5M | 8 |
| HISPANIC SCHOLARSHIP FUND | El Segundo | B820 Education | $54.5M | 8 |
| CORPORATION OF THE FINE ARTS MUSEUMS | San Francisco | A035 Arts, Culture & Humanities | $54.3M | 14 |
| WESTERN STATES PETROLEUM ASSOCIATION | Sacramento | — | $54.2M | 10 |
| CHAN ZUCKERBERG INITIATIVE ADVOCACY | Palo Alto | W12 Public & Societal Benefit | $54.2M | 0 |
| SALUD PARA LA GENTE | Watsonville | — | $54M | 11 |
| POSSIBILITY LABS | San Francisco | P20 Human Services | $54M | 7 |
| LA JOLLA COUNTRY DAY SCHOOL | La Jolla | — | $54M | 7 |
| SAMUELI FOUNDATION | Corona Del Mar | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $54M | 1 |
| GOODWILL RETAIL SERVICES | Los Angeles | J11 Employment | $53.9M | 8 |
| TLCS INC | Sacramento | F34Z Mental Health & Crisis Intervention | $53.9M | 8 |
| SAN DIEGO TOURISM MARKETING | San Diego | S40 Community Improvement & Capacity Building | $53.8M | 1 |
| Clinica De Salud Del Valle De Salinas | Salinas | E320 Health Care | $53.7M | 9 |
| ARC RESEARCH INSTITUTE | Palo Alto | H99 Medical Research | $53.6M | 16 |
| OPERATING ENGINEERS VACATION-HOLIDAY | Pasadena | — | $53.5M | 7 |
| COMMUNITY SOLUTIONS FOR CHILDREN | Gilroy | — | $53.3M | 10 |
| CALIFORNIA UNIVERSITY OF SCIENCE AND | Colton | B43 Education | $53.2M | 16 |
| Central City Community Health Center Inc | Monterey Park | Z99 Unknown | $53M | 9 |
| ARARAT HOME OF LOS ANGELES | Mission Hills | E910 Health Care | $53M | 8 |
| SAN DIEGO BLOOD BANK | San Diego | — | $52.9M | 12 |
| THE LOS ANGELES FREE CLINIC | Los Angeles | E32Z Health Care | $52.8M | 6 |
| THE HERB ALPERT FOUNDATION | Santa Monica | — | $52.8M | 1 |
| ISANA | Los Angeles | B29 Education | $52.7M | 7 |
