| THE MICHAEL AND LORI MILKEN FAMILY FOUNDATION | Santa Monica | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $60.5M | 1 |
| The Claremont Colleges Inc | Claremont | B11 Education | $60.4M | 19 |
| Fuller Theological Seminary | Pasadena | B500 Education | $59.9M | 13 |
| FOODBANK OF SOUTHERN CALIFORNIA | Long Beach | K31Z Food, Agriculture & Nutrition | $59.7M | 0 |
| Chico State Enterprises | Chico | B110 Education | $59.6M | 15 |
| Los Angeles Centers for Alcohol and Drug Abuse | Santa Fe Springs | — | $59.5M | 7 |
| AQUARIUM OF THE PACIFIC CORPORATION | Long Beach | D500 Animal-Related | $59.3M | 13 |
| APHORISM FOUNDATION C/O REALIZE CPA LLP | San Francisco | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $59.3M | 0 |
| CALIFORNIA SCIENCE CENTER FOUNDATION | Los Angeles | A570 Arts, Culture & Humanities | $59.2M | 9 |
| AREA HOUSING AUTHORITY OF THE COUNTY OF VENTURA | Newbury Park | L210 Housing & Shelter | $59.1M | 20 |
| WASHINGTON TOWNSHIP MEDICAL FOUNDATION | Fremont | E31 Health Care | $59.1M | 11 |
| JOHN MUIR BEHAVIORAL HEALTH | Walnut Creek | F30Z Mental Health & Crisis Intervention | $59.1M | 9 |
| WHITTIER COLLEGE | Whittier | B430 Education | $59M | 12 |
| GOODWILL OF SILICON VALLEY INC | San Jose | — | $59M | 7 |
| SALUD PARA LA GENTE | Watsonville | — | $59M | 11 |
| CHUCK LORRE FAMILY FOUNDATION | Los Angeles | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $59M | 1 |
| Safe 1 Credit Union | Bakersfield | W61 Public & Societal Benefit | $59M | 16 |
| SMART-MTA TRUST FUND | Irwindale | — | $58.9M | 9 |
| Rural Community Assistance Corporation | West Sacramento | S200 Community Improvement & Capacity Building | $58.8M | 9 |
| ASTERA INSTITUTE | Berkeley | U41 Science & Technology | $58.7M | 0 |
| South County Community Health Center Inc dba Ravenswood Family Health Center | East Palo Alto | E32 Health Care | $58.7M | 12 |
| Legal Aid Foundation of Los Angeles | Los Angeles | I80Z Crime & Legal-Related | $58.6M | 8 |
| CALIFORNIA ASSOCIATION OF REALTORS | Sacramento | — | $58.6M | 98 |
| SAN DIEGO CONVENTION AND TOURIST BUREAU | San Diego | — | $58.5M | 9 |
| SAGE OAK CHARTER SCHOOL | Redlands | B29 Education | $58.4M | 18 |
| HOMEFIRST SERVICES OF SANTA CLARA COUNTY | Milpitas | — | $58.3M | 9 |
| UNION RESCUE MISSION | Los Angeles | P600 Human Services | $58.2M | 10 |
| SUMMIT PUBLIC SCHOOLS | Redwood City | B25 Education | $58.2M | 7 |
| AMERICAN JEWISH UNIVERSITY | Los Angeles | B420 Education | $58.2M | 16 |
| UNITED DOMESTIC WORKERS OF AMERICA | San Diego | — | $58.2M | 18 |
| THE THORNTON FOUNDATION DELAWARE | San Marino | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $57.8M | 0 |
| FRANCIS PARKER SCHOOL | San Diego | B200 Education | $57.8M | 7 |
| SAVE THE REDWOODS LEAGUE | San Francisco | C360 Environment | $57.8M | 10 |
| Clinica De Salud Del Valle De Salinas | Salinas | E320 Health Care | $57.7M | 9 |
| GATEWAYS HOSPITAL & MENTAL HEALTH CENTER | Los Angeles | F31Z Mental Health & Crisis Intervention | $57.7M | 14 |
| SAN FRANCISCO BALLET ENDOWMENT FOUNDATION | San Francisco | A020 Arts, Culture & Humanities | $57.6M | 3 |
| SONOMA COUNTY INDIAN HEALTH PROJECT INC | Santa Rosa | E39Z Health Care | $57.6M | 7 |
| PASO ROBLES HORSE PARK FOUNDATION INC | Paso Robles | N69 Recreation & Sports | $57.3M | 0 |
| DART-L FOUNDATION | Los Angeles | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $57.2M | 6 |
| MENDOCINO COMMUNITY HEALTH CLINIC INC | Ukiah | E32Z Health Care | $57.2M | 8 |
| CORPORATION OF THE FINE ARTS MUSEUMS | San Francisco | A035 Arts, Culture & Humanities | $57.1M | 13 |
| COMPREHENSIVE COMMUNITY HEALTH CENTERS INC | Glendale | E300 Health Care | $57.1M | 14 |
| AUTOMOTIVE INDUSTRIES WELFARE FUND | Dublin | — | $57M | 1 |
| YOUNG MEN'S CHRISTIAN ASSOCIATION OF ORANGE COUNTY | Tustin | P27Z Human Services | $56.9M | 11 |
| RIVER PARTNERS | Chico | C30 Environment | $56.9M | 8 |
| JEWISH FEDERATION COUNCIL OF GREATER LA | Los Angeles | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $56.9M | 15 |
| ILEAD CALIFORNIA CHARTERS 1 | Acton | B11 Education | $56.8M | 10 |
| WILDLIFE CONSERVATION NETWORK INC | San Francisco | D30 Animal-Related | $56.7M | 7 |
| Los Angeles Dependency Lawyers Inc | Monterey Park | I80 Crime & Legal-Related | $56.7M | 9 |
| ISANA | Los Angeles | B29 Education | $56.7M | 8 |
