| SIENA HEIGHTS UNIVERSITY | Adrian | B430 Education | $60.9M | 5 |
| FOOD BANK OF EASTERN MICHIGAN | Flint | K310 Food, Agriculture & Nutrition | $60.9M | 2 |
| SCHEURER HOSPITAL | Pigeon | E22Z Health Care | $60.7M | 21 |
| Our Heart Foundation | Grand Blanc | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $60.2M | 0 |
| MICHIGAN EDUCATION ASSOCIATION | East Lansing | — | $60M | 10 |
| CHERRYLAND ELECTRIC COOPERATIVE INC | Grawn | — | $59.8M | 16 |
| DETROIT COUNTRY DAY SCHOOL | Beverly Hills | B20 Education | $59M | 7 |
| Flint and Genesee Group Foundation | Flint | — | $58.9M | 4 |
| Family Health Center Inc | Kalamazoo | E320 Health Care | $58.8M | 10 |
| WESTERN MICHIGAN UNIVERSITY | Kalamazoo | B110 Education | $58.8M | 4 |
| MUNSON HEALTHCARE MANISTEE | Manistee | E22 Health Care | $58.6M | 16 |
| SAGINAW COOPERATIVE HOSPITALS INC | Saginaw | E21Z Health Care | $58.6M | 6 |
| Peninsula Generation Cooperative | Cadillac | W80 Public & Societal Benefit | $58.1M | 5 |
| INTERLOCHEN ARTS GROUP | Interlochen | B25 Education | $57.5M | 3 |
| MATRIX HUMAN SERVICES | Detroit | — | $57.3M | 4 |
| GRACE HEALTH INC | Battle Creek | E32 Health Care | $57.1M | 10 |
| CREDIT UNIONS CHARTERED IN THE STATE OF | Battle Creek | — | $57M | 11 |
| THE RONDA E STRYKER AND WILLIAM D | Kalamazoo | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $56.8M | 1 |
| Schoolcraft Memorial Hospital | Manistique | E20 Health Care | $56.2M | 16 |
| MICHIGAN PRIMARY CARE ASSOCIATION | Lansing | E31Z Health Care | $54.9M | 7 |
| ZEAL CREDIT UNION | Livonia | — | $54.8M | 8 |
| Madonna University | Livonia | B430 Education | $54.8M | 10 |
| THE GUIDANCE CENTER | Southgate | F32Z Mental Health & Crisis Intervention | $54.6M | 9 |
| DETROIT ZOOLOGICAL SOCIETY | Royal Oak | D500 Animal-Related | $54.3M | 12 |
| CREDIT UNIONS CHARTERED IN THE STATE OF | Midland | — | $54.3M | 12 |
| REGION VII AREA AGENCY ON AGING | Bay City | P81 Human Services | $54.1M | 18 |
| MERCY-USA FOR AID & DEVELOPMENTINC | Plymouth | Q300 International, Foreign Affairs & National Security | $54.1M | 3 |
| INTL BROTHERHOOD ELECTRICAL WORKERS | Troy | — | $53.7M | 3 |
| Cornerstone University | Grand Rapids | B430 Education | $53.6M | 10 |
| COMMUNITY FOUNDATION OF GREATER FLINT | Flint | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $53.6M | 8 |
| FORD MOTOR COMPANY FUND | Dearborn | — | $53.1M | 0 |
| TRINITY HEALTH GRAND HAVEN HOSPITAL | Grand Haven | E220 Health Care | $52.7M | 11 |
| MCLAREN THUMB REGION | Bad Axe | E22 Health Care | $52.5M | 8 |
| AQUINAS COLLEGE | Grand Rapids | B430 Education | $52.3M | 6 |
| MYMICHIGAN MEDICAL CENTER GLADWIN | Gladwin | E22 Health Care | $50.7M | 13 |
| COMMUNITY LIVING SERVICES INC | Wayne | P820 Human Services | $50.6M | 7 |
| ALCONA CITIZENS FOR HEALTH INC | Alpena | E39Z Health Care | $50.5M | 8 |
| The Young Men's Christian Association of Greater Grand Rapids (3019) | Grand Rapids | P270 Human Services | $50.5M | 8 |
| RESEARCH FOUNDATION OF THE CITY | Detroit | Y43 Mutual & Membership Benefit | $50.4M | 1 |
| Arbor Financial Credit Union | Kalamazoo | — | $50.2M | 11 |
| BARUCH SLS INC | Grand Rapids | L99 Housing & Shelter | $50.2M | 3 |
| The Wing Shadow Foundation | Ada | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $49.5M | 0 |
| ARAB COMMUNITY CENTER FOR ECONOMIC AND S | Dearborn | P280 Human Services | $49.5M | 5 |
| FUND FOR MEDICAL RESEARCH AND EDUCATION | Detroit | — | $49.5M | 24 |
| BAKER COLLEGE PROFESSIONAL SERVICES | Owosso | B42 Education | $48.6M | 12 |
| PFCU | Portland | — | $48.6M | 7 |
| BALDWIN FAMILY HEALTH CARE INC | Baldwin | — | $48.1M | 11 |
| UNITED JEWISH FOUNDATION | Bloomfield Hills | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $48M | 9 |
| MHT HOUSING IV INC | Bingham Farms | L20Z Housing & Shelter | $47.4M | 3 |
| MICHIGAN HEALTH INFORMATION NETWORK | Lansing | E800 Health Care | $47.3M | 24 |
