| ROSS EDUCATION HOLDINGS INC | Clinton Township | — | $65.4M | 7 |
| COREWELL HEALTH FOUNDATION WEST MICHIGAN | Grand Rapids | E21 Health Care | $65.2M | 6 |
| THE RONDA E STRYKER AND WILLIAM D JOHNSTON FOUNDATION | Kalamazoo | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $63.6M | 1 |
| MATRIX HUMAN SERVICES | Detroit | — | $63.3M | 3 |
| CURE INTERNATIONAL INC | Grand Rapids | Q30 International, Foreign Affairs & National Security | $63.2M | 11 |
| RESEARCH FOUNDATION OF THE CITY | Detroit | Y43 Mutual & Membership Benefit | $63M | 1 |
| GENESEE EDUCATION CONSULTANT SERVICES | Flint | B19 Education | $62.8M | 2 |
| FEEDING AMERICA WEST MICHIGAN | Kentwood | — | $62.7M | 3 |
| Spring Arbor University | Spring Arbor | B430 Education | $62.4M | 6 |
| Peninsula Generation Cooperative | Cadillac | W80 Public & Societal Benefit | $62.4M | 6 |
| WILDFIRE CREDIT UNION | Saginaw | — | $62.1M | 8 |
| JEWISH FEDERATION OF DETROIT | Bloomfield Hills | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $62M | 8 |
| MICHIGAN HEALTH & HOSPITAL ASSOCIATION D/B/A MHA | Okemos | — | $61.9M | 7 |
| Michigan Electrical Employees Health Plan | Madison Heights | — | $61.8M | 4 |
| THE KRESGE FOUNDATION | Troy | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $61.3M | 18 |
| TRINITY HEALTH GRAND HAVEN HOSPITAL (F/K/A NORTH OTTAWA COMMUNITY HOSPITAL) | Grand Haven | E220 Health Care | $61M | 13 |
| ASCENSION ST JOSEPH HOSPITAL | Midland | E20 Health Care | $60.8M | 11 |
| Our Heart Foundation | Grand Blanc | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $60.2M | 0 |
| MICHIGAN EDUCATION ASSOCIATION | East Lansing | — | $60M | 10 |
| DETROIT COUNTRY DAY SCHOOL | Beverly Hills | B20 Education | $59.7M | 7 |
| Flint and Genesee Group Foundation | Flint | — | $58.9M | 4 |
| MUNSON HEALTHCARE MANISTEE HOSPITAL | Manistee | E22 Health Care | $58.8M | 15 |
| Family Health Center Inc | Kalamazoo | E320 Health Care | $58.8M | 10 |
| WESTERN MICHIGAN UNIVERSITY FOUNDATION | Kalamazoo | B110 Education | $58.8M | 4 |
| SAGINAW COOPERATIVE HOSPITALS INC DBA/CMU MEDICAL EDUCATION PARTNERS | Saginaw | E21Z Health Care | $57.8M | 6 |
| INTERLOCHEN ARTS GROUP | Interlochen | B25 Education | $57.5M | 3 |
| Madonna University | Livonia | B430 Education | $57.5M | 8 |
| Aquinas College | Grand Rapids | B430 Education | $57.2M | 7 |
| GRACE HEALTH INC | Battle Creek | E32 Health Care | $57.1M | 10 |
| CREDIT UNIONS CHARTERED IN THE STATE OF MICHIGAN | Battle Creek | — | $57M | 11 |
| Schoolcraft Memorial Hospital | Manistique | E20 Health Care | $56.2M | 16 |
| SIENA HEIGHTS UNIVERSITY | Adrian | B430 Education | $55.3M | 10 |
| FORD PHILANTHROPY | Dearborn | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $55.2M | 0 |
| MYMICHIGAN MEDICAL CENTER GLADWIN | Gladwin | E22 Health Care | $55M | 9 |
| MICHIGAN PRIMARY CARE ASSOCIATION | Lansing | E31Z Health Care | $54.9M | 7 |
| ZEAL CREDIT UNION | Livonia | — | $54.8M | 8 |
| THE GUIDANCE CENTER | Southgate | F32Z Mental Health & Crisis Intervention | $54.6M | 9 |
| DETROIT ZOOLOGICAL SOCIETY | Royal Oak | D500 Animal-Related | $54.3M | 12 |
| CREDIT UNIONS CHARTERED IN THE STATE OF MICHIGAN | Midland | — | $54.3M | 12 |
| REGION VII AREA AGENCY ON AGING | Bay City | P81 Human Services | $54.1M | 18 |
| MERCY-USA FOR AID & DEVELOPMENTINC | Plymouth | Q300 International, Foreign Affairs & National Security | $54.1M | 3 |
| Gordon Christian Trust | Grand Rapids | T900 Philanthropy, Voluntarism & Grantmaking Foundations | $53.8M | 0 |
| INTL BROTHERHOOD ELECTRICAL WORKERS LOCAL 17 HEALTH & WELFARE FUND | Troy | — | $53.7M | 3 |
| Cornerstone University | Grand Rapids | B430 Education | $53.6M | 10 |
| COMMUNITY FOUNDATION OF GREATER FLINT | Flint | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $53.6M | 8 |
| MCLAREN THUMB REGION | Bad Axe | E22 Health Care | $52.5M | 8 |
| SPARROW CARSON HOSPITAL | Carson City | E220 Health Care | $51.5M | 15 |
| COMMUNITY LIVING SERVICES INC | Wayne | P820 Human Services | $50.6M | 7 |
| ALCONA CITIZENS FOR HEALTH INC | Alpena | E39Z Health Care | $50.5M | 8 |
| The Young Men's Christian Association of Greater Grand Rapids (3019) | Grand Rapids | P270 Human Services | $50.5M | 8 |
